ObjectiveTo compare the effect of psychological treatment only and psychological combined with fluoxetine treatment in reducing symptom of depression, anxiety and in improving of cognitive and daily living abilities for post-stroke depression patients.MethodsAll patients with post-stroke enrolled in hospital between 1996 and 2001 and were evaluated by using of the Self-rating Depression Scale (SDS), the Self-rating Anxiety Scale (SAS), Scale of Elderly Cognitive Function (SECF), and Ability of Daily Living (ADL). SDS score was equal or greater than 50 points (SDS≥50) selected as subjects for this study. A total of 115 patients were randomized divided into psychological with fluoxetine treatment group (Group A,54 patients) and psychological treatment group (Group B,61 patients). There is no significant difference between two groups in age, education, and left or right side of hemiplegics. Statistical analysis was performed by using Chi test and t test to compare the 2 groups at day 0 (baseline) and after 2 months.ResultsThe level of depression and anxiety reduced significantly in both Group A and Group B from baseline to end of treatment (P<0.001). Both groups had significant improvement in daily living ability (P<0.001).There was no significant improvement in cognitive ability (P>0.5). There was no significant differences on SDS, SAS, SECF, and ADL scores from baseline to end of treatment (P>0.5).Conclusions There were similar effect of psychological with fluoxetine treatment and of psychological treatment only on post-stroke depression.

ObjectiveTo analyze the relationship among depression and anxiety and other possible factors in post-stroke patients.Methods510 hospitalized stroke patients from 1997 to 2004 were evaluated with the Scale of Elderly Cognitive Function (SECF), Self-Rating Depression Scale (SDS), Self-Rating Anxiety Scale (SAS), and Activities of Daily Living (ADL) in 7 days after admission and re-examined after two months.ResultsThe depression group exhibited the longer course of disease, a high ratio of hemiplegia in left side, lower ADL scores and higher SAS scores at time of admission. There were significant differences between depression and non-depression group. However, there was no significant difference between the depression and cognitive function. There were also significant differences between anxiety group and non-anxiety group. Patients with anxiety displayed symptoms of low ADL scores and higher SDS scores at time of admission, and ADL scores increased after treatment. Additionally, the course of disease was longer and reduction of anxiety level was lower. The levels of depression and anxiety significantly reduced in depression group and anxiety group when compared to the control group.ConclusionEarly rehabilitation can help to reduce depression level. Modest anxiety may help stroke patients to improve their ADL. There is close relationship between depression and anxiety.

Objective To analyze the injury mechanism and distribution of the motor vehicle engine shake shaft caused injuries (MVESSCI) in North Henan province. Methods A follow up was done on 520 patients with the motor vehicle engine shaft injuries treated in our hospital from January 1998 to May 2002. The epidemiological features were analyzed concerning gender, age, injury time and injury sites. Results There were 300 males and 220 females (age range of 9-53 years, mean 31 years) with ratio 1.36 ∶1 of male to female. The MVESSCI were dominated by Colles fractures and distal fractures of ulna and radius, accounting for 73.8% (384/520). The traffic accidents occurred most in May, June, September and October, which accounted for 85.0% (442/520). Conclusions (1) The vehicle engine shake shaft causes the injuries mainly at the distal part of the right forearm, mainly the Colles fracture and the distal fractures of ulna and radius. (2) The injury is mainly due to improper operation in busy farming seasons. (3) The countermeasures to reduce wounds and injuries are to pay much more attention to prevention, strengthen the safety awareness of individuals, improve the structures of motor vehicles and avoid improper manipulation of the vehicles by children.

Adult ; Aged ; Digoxin ; therapeutic use ; Drug Therapy, Combination ; Drugs, Chinese Herbal ; therapeutic use ; Female ; Heart Failure ; drug therapy ; Humans ; Male ; Middle Aged ; Phytotherapy

Humans ; Purpura, Thrombocytopenic, Idiopathic

During the past 30 years, Alzheimer's disease (AD) drug R&D aiming at a variety of potential targets has undergone tremendous setback although a large amount of resources have been invested by pharmaceutical companies, governments, academic institutions and venture capitals globally. There is no doubt that uneasy early diagnosis, unsatisfying therapeutic strategies and genetic polymorphism of AD patients bringing variety of responses to the drugs contribute to the failure of AD drug therapy, but the most important reason might be that people have insufficient understanding of the very complex diseases including AD. Continuing to make efforts in the previous way to find AD drugs might not be a good way. Development of systems biomedicine opens an avenue to understand the disease networks and pursue multi-target drugs R&D based on systems pharmacology theory; neural stem cell transplantation, and neurogenesis affected by small molecules might bring new hope for AD therapy; discovery of new biomarkers of AD will help the study of the pathogenesis and diagnosis of the disease and finally the discovery of new types of AD drugs.
Alzheimer Disease ; drug therapy ; Biomedical Research ; trends ; Humans

OBJECTIVE: To realize the general use of product managing software in management of drugs in modern hospital. METHOD: The softwares for import, sales and storage of pharmaceutical products in modern hospital were analyzed and compared. The type with best data transplant was found out and grafted upon the module relation. The network technology of programming tool VB was adopted to establish the sensitivity of the effective word section in the database , and the structure of the data was set up in an selective way in the procedure initializing window. RESULTS: The chaining of the system with many kinds of databases was completed. CONCLUSION: The modern programming technology combined with effective establishment of the database can be employed to transplant the complicated data, and therefore the medicine management software can be expected to be in general use.

153 TMD patients were randomized to be treated by closed treatment of Kenalog(78 cases)and prednisolone(75 cases)respec-tively.Data were analyzed by SPSS 17.0.4-week-follow-up showed that Kenalog closed treatment was more effective than prednisolone(P<0.05).

0.05),but the positive degrees were distinctly different(P0.05). Conclusion:The status of p53 may be related with multidrug resistance and the p53 positive tumors possibly show low sensitivity to chemotherapy.

Objective:To summarize the experience of retroperitoneoscopic renal pedicle lymphatic disconnection in the management of chyluria,and to investigate a new minimally invasive treatment of chyluria. Methods:9 cases of chyluria were treated by retroperitoneoscopic renal pedicle lymphatic disconnection from Jan 2005 to Dec 2008 with 7 male ones and 2 female ones. The average age was 48 years. 8 of 9 cases obtained success and 1 of 9 cases was converted to open surgery. Operation time, blooding volume, postoperative complication and hospitalization stay, and the operative effect were observed. Results:The operation time was from 65 to 105 min,with the average of 70 min. The blooding volume was from 50 to 100ml, with the average of 60ml. Chyluria disappeared immediately after operation in all patients. Postoperative stay was from 5 to 7d and no complication happened. Conclusion:Retroperitoneoscopic renal pedicle lymphatic disconnection for chyluria is a effective and efficienl method in the management of chyluria. And it is also safe , minimally invasive , with less blood loss, fewer complications , and short hospital stay .