Humans ; Purpura, Thrombocytopenic, Idiopathic

Hemorrhage ; pathology ; Humans ; Thrombocytopenia ; pathology

Adult ; Humans ; Purpura, Thrombocytopenic, Idiopathic ; diagnosis ; therapy

Objective To assess the clinical effects of Shenfu injection which consists mainly of panaxoside and water-solubility alkaloied on chronic pulmonary heart disease complicated with heart failure.Methods Ninetysix patients were randomly divided into two groups ,40 patients underwent regular treatment (control group) and 56 patients were treated with Shenfu injection additionally to regular treatment (treatment group ).There were 2 treatment durations,with 15 days in one duration.The symptoms,left ventricular ejection fraction (LVEF) and B type UNa peptide (BNP) were measured before and after treatment.Results The total effective rate in the treatment group was 91.1% (51/56) ,which was significantly higher than that in the control group (72.5% ,29/40) (P ＜0.05 ).After treatment,the treatment group has significantly higher LVEF than the control group(53.27% ±7.45%vs.49.12% ± 5.89% ) ( P ＜ 0.05 ),and significantly lower BNP ( ( 209.1 ± 18.7 ) ng/L vs.( 261.2 ± 19.3 ) ng/L ( P ＜ 0.05).Conclusions Shenfu injection could strengthen the contractility and increase LVEF,therefore improve the function of left ventricle,as well as decrease BNP and repair heart failure.

Objective:To explore the perioperative safety management of patients with severe limb dysplasia, to select appropriate methods to monitor vital signs, and to prevent intraoperative acquired pressure sore, nosocomial infection and other related complications.Methods:A case of severe developmental disorder of extremities caused by acroscleroderma in November 2019 in Peking University Shenzhen Hospital needed to be amputated. By organizing multidisciplinary consultation to discuss the operation plan, repeatedly selecting appropriate tools, and multiple scenario simulation exercises, continuous transcutaneous oxygen saturation and noninvasive blood pressure monitoring could be realized for the patients with acromegaly deficiency of the extremities. Under the monitoring of color ultrasound, the arterial blocking pressure of the extremities was determined as the tourniquet pressure during the operation value, take appropriate measures to prevent intraoperative acquired pressure sore, nosocomial infection and other related complications.Results:With the cooperation of multidisciplinary team, amputation was successfully carried out for the patients. The position was comfortable during the operation, the operation process was smooth, the residual limbs healed well after the operation, and there was no intraoperative acquired pressure sore, nosocomial infection and other related complications.Conclusions:To establish a multidisciplinary cooperation mechanism, strengthen the construction of the operating room special group, and use evidence-based nursing methods and actual scenario simulation exercise can ensure the perioperative safety of patients with severe developmental disorder of extremities and similar patients with special body shape or very low weight.

Adult ; Aged ; Antineoplastic Combined Chemotherapy Protocols ; administration & dosage ; therapeutic use ; Boronic Acids ; administration & dosage ; therapeutic use ; Bortezomib ; Female ; Humans ; Male ; Middle Aged ; Multiple Myeloma ; drug therapy ; Pyrazines ; administration & dosage ; therapeutic use

Objective: To test the mechanical properties o f N48 NdFeB magnet.Methods:Samples of N48 NdFeB magnet in the size of 2 mm?3 mm?4 mm were prepared, the residual flux density,coercive force and maximum energy product of the samples were measured, the magnetic density aroun d the magnets,the attractive and repulsive force between two magnets in 0~10 mm air gap were investegated.Results:The residual flux density of t he N48 NdFeB magnet was 1.373 T, coercive force 1 037 A/m and maximum energ y product 368 kJ/m 3.The magnetic density at magnet surface was 0.338 T,it decr eased to 0 at the point that leave magnet surface 20 mm away. The highest attrac tive force was 4.47 N between two magnets, the attractive force was 4.47~0.39 N in 0~5 mm air gap.The highest repulsive force was 2.82 N and the repulsive force was 2.82~0.39 N in 0~5 mm air gap.Conclusion:The magnetic and m echanical properties of the N48 NdFeB magnet can meet the standard of the orthod ontic force.

Objective To evaluate the results of the Secuplate anterior cervical osteosynthesis plate (SACOP) for the treatment of patient with cervical spondylotic myelopathy (CSM). Methods Twenty six patients with CSM underwent anterior decompression fusion and internal fixation with SACOP were reviewed. All patients were followed up for 6 to 12 months (mean, 8 months). Results Neurological deficits improved in 23 of 26 patients after operation. A stable bony fusion according to radiological criteria was achieved in all cases 6 months postoperatively. There was no implants breakage and loosening. Conclusion Intervertebral fusion and internal fixation with SACOP after anterior decompression can offer immediate stability, prevent graft dislodgement, avoid cast immobilization and give a high rate of successful bony fusion for the patient with CSM.

Objective To review and analyze the sexual function of patients with spinal fractures complicated by incomplete paraparesis. Methods A total of 73 patients with incomplete paraparesis resulted from spinal fractures were retrospectively analyzed. Frankel Grade was used to determine the neurologic function and international index of ecrectile function (IIEF) to evaluate patients' sexual function. The patients with sexual dysfunction also were examined for reflex erection and psychogenic erection function. Results There were 21 patients with sexual dysfunction. Through ?2 test, significant difference was found between Frankel grade B and grade C as well as between grade D and grade E (P

Cofactor engineering, a vital part of metabolism engineering, changes the redox cofactor regeneration approach. Its main goal is to rebuild the components of metabolic products. The bioconversion of xylose for the production of ethanol is being studied intensively because ethanol is an alternative energy source and a potential liquid fuel. Saccharomyces cerevisiae has been traditionally used in producing ethanol from fermentable sugars but it cannot utilize xylose, only its isomer xylulose. Introduction of the xylose fermentation pathway from Pichia stipitis into S. cerevisiae enables xylose utilization in recombinant S. cerevisiae, but the ethanol yields of xylose fermentation with recombinant S. cerevisiae has been low and large amounts of the byproduct xylitol are produced. The major reason is that the catabolism of xylose with the fungal pathway leads an imbalance of redox cofactor. The process of the catabolism of xylose requires NADPH and NAD~+, both of which have to be regenerated in separated processes. More and more attention has therefore focused on the redox cofactor balance in S. cerevisia. The research progress of cofactor engineering to solve the imbalance of redox cofactor in xylose metabolism recombinant S. cerevisiae was introduced. This included expression of transhydrogenase, increasing the utilization of NADPH, and achieving the anaerobic reoxidation of NADH. Reversing the cofactor specificity of enzymes is another effective way.