The models of both auxiliary partial orthotopic liver transplantation(APOLT)andacute liver failure were established.Acute liver failure in rats was successfully induced by partialhepatectomy of 75%with the remnant liver ischemia for 50 min.In treated group,the recipientsunderwent APOLT before the remnant liver(the right superior and inferior lobes)receiving tem-porary ischemia for 50 min.The experimental results showed that the 5-day survival rate of therats with acute liver failure was only 3%,while in the rats receiving APOLT,the 5-day survivalrate of the recipients and the liver graft was 80%and 73%,respectively.The liver function re-turned near tO normal level on the 5th postoperative day.It is suggested that acute liver failure in-duced by major liver resection with remnant liver ischemia in rat is an ideal model and APOLTmight provide an exact support for experimental acute liver failure in rat.