1.Pathological analysis of pancreatic colloid carcinoma in 7 cases.
Xia MIN ; Ji-zhong GUO ; Qiang ZHAN
Chinese Journal of Oncology 2007;29(5):377-378
Adenocarcinoma, Mucinous
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metabolism
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pathology
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surgery
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Aged
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Biomarkers, Tumor
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metabolism
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Carcinoembryonic Antigen
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metabolism
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Carcinoma, Pancreatic Ductal
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metabolism
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pathology
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surgery
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Carcinoma, Papillary
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metabolism
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pathology
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surgery
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Cystadenocarcinoma, Mucinous
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metabolism
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pathology
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surgery
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Diagnosis, Differential
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Duodenal Neoplasms
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metabolism
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pathology
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surgery
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Female
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Follow-Up Studies
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Humans
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Immunohistochemistry
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Male
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Middle Aged
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Mucin-2
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Mucins
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metabolism
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Neoplasm Invasiveness
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Pancreatic Neoplasms
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metabolism
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pathology
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surgery
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Pancreaticoduodenectomy
2.Combination therapy with Octreotide and Ulinastatin for improving the prognosis of elderly patients with severe acute pancreatitis
Min LIU ; Jianyong CHEN ; Li ZHAO ; Linlin SHI ; Xia JIANG ; Zhaolin ZHANG ; Dongya CHEN ; Chenger ZHAN
Chinese Journal of Geriatrics 2021;40(2):182-187
Objective:To investigate the clinical value of Octreotide plus Ulinastatin in the treatment of severe acute pancreatitis(SAP)in elderly patients.Methods:From May 2016 to February 2019, 124 elderly SAP patients admitted to the gastroenterology department of our hospital were enrolled and divided into the combination therapy group and the control group, with 62 patients in each group.The combination therapy group was treated with Octreotide and Ulinastatin, while the control group was treated with Octreotide alone.Serum leukocyte count, C-reactive protein(CRP), interleukin(IL)-6, tumor necrosis factor(TNF)-α and amylase levels were monitored before and 1, 3, 5, 7 and 14 days after treatment by automated biochemical analysis and enzyme-linked immunosorbent assays.The pain grade scale, APACHE-Ⅱ score and efficacy evaluation were analyzed for the two groups 7 days after treatment.The time to oral refeeding and length of hospitalization were compared between the two groups, and related complications during the treatment were recorded.Complications and the recurrence of pancreatitis within 1 year were followed up in both groups.Results:There was no statistically significant difference in serum white blood cell count, CRP, amylase, IL-6 and TNF-α levels between the two groups before treatment(all P>0.05). Serum white blood cell count, CRP and TNF-α levels had significant differences( t=3.735, 2.851 and -2.147, P=0.036, 0.029 and 0.043)and serum amylase and IL-6 levels had no significant difference( P>0.05)between the two groups 3 days after treatment.All the above parameters had significant differences between the two groups 7 days after treatment( t=3.624, 2.918, -2.166, 2.684 and -2.593, P=0.023, 0.011, <0.001, 0.015 and <0.001). Serum amylase, IL-6 and TNF-α levels had significant differences( t=-3.515, 4.627 and -3.189, all P<0.001)and serum white blood cell count and CRP had no significant difference(all P>0.05)between the two groups 14 days after treatment.There were significant differences in visual analogue scale(VAS)and APACHE-Ⅱ score between the two groups 7 days after treatment( t=-2.346 and -3.245, P=0.021 and 0.002). On the 7th day after treatment, the effectiveness rate was 79.0%(49/62)in the combination therapy group and 61.3%(38/62)in the control group, with a significant difference between the two groups( χ2=4.661, P=0.031). Compared with the control group, time to oral refeeding and hospitalization length were shorter in the combination therapy group than in the control group(6.72±1.87 d vs.7.65±1.69 d, 11.23±2.98 d vs.13.85±3.42 d, t=-2.868 and -4.565, both P<0.05). There were significant differences in the incidences of infectious pancreatic necrosis, gastrointestinal adverse reactions and organ failure between the combination therapy group and the control group(11.3% or 7/62 vs.25.8% or 16/62, 43.5% or 27/62 vs.21.0% or 13/62, 1.6% or 1/62 vs.11.3% or 7/62, χ2=4.324, 7.233 and 4.810, P=0.038, 0.007 and 0.028). There were significant differences in mean length of time without complications and recurrence between the combined group and the control group(10.25±3.26 months vs.8.72±3.73 months, 10.69±2.51 months vs.9.62±2.92 months, Log Rank χ2=7.463 and 4.589, P=0.006 and 0.032). Conclusions:Octreotide combined with Ulinastatin can effectively alleviate local symptoms, slow clinical progression, reduce the risk of complications, decrease the recurrence rate and promote early recovery in elderly SAP patients.
3.Chemical constituents of Dalbergia odorifera.
Hao WANG ; Wen-Li MEI ; Zhi-Kai GUO ; Zhan-Feng XIA ; Hui-Min ZHONG ; Hao-Fu DAI
China Journal of Chinese Materia Medica 2014;39(9):1625-1629
Fourteen compounds were isolated from Dalbergia odoriferae and purified by repeated column chromatography on silica and sephadex LH-20 gel and structurally identified by spectral analysis. These compounds were identified as 4, 9-dimethoxy-3-hydroxypterocarpan (1), medicarpin (2), 2', 4', 5-trihydroxy-7-methoxyisoflavone (3), 2', 3', 7-trihydroxy-4'-methoxyisoflavan (4), formononetin (5), 3, 8-dihydroxy-9-methoxypterocarpan (6), koparin (7), 3-hydroxy-9-methoxypterocarp-6a-ene (8), 2'-hydroxyformononetin (9), stevenin (10), 2', 7-dihydroxy-4', 5'-dimethoxyisoflavone (11), lyoniresinol (12), 2, 4-dihydroxy-5-methoxy-benzophenone (13) and neokhriol A (14). Compounds 1, 3, 4, 6, 8, 12 and 14 were isolated from this plant for the first time. Antibacterial activity assay showed that compound 4 had inhibitory effect on Ralstonia solanacearum.
Anisoles
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chemistry
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isolation & purification
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pharmacology
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Anti-Bacterial Agents
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chemistry
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isolation & purification
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pharmacology
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Benzophenones
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chemistry
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isolation & purification
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pharmacology
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Chromatography
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methods
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Dalbergia
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chemistry
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Dextrans
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Gels
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Isoflavones
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chemistry
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isolation & purification
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pharmacology
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Microbial Sensitivity Tests
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Naphthalenes
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chemistry
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isolation & purification
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pharmacology
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Plant Extracts
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chemistry
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isolation & purification
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pharmacology
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Pterocarpans
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chemistry
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isolation & purification
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pharmacology
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Ralstonia solanacearum
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drug effects
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growth & development
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Silica Gel
4.The relationship between the p53 expression and MRI manifestion of the T-staging and the lymph nodes metastasis of the nasopharyngeal carcinoma
Zhong YANG ; Jian-Min XU ; Jun SHAN ; Jie MA ; Zhan-Tong XIA ; Jiang-Bo YU ; Hui-Ling HE ;
Chinese Journal of Radiology 1999;0(10):-
0.05).The expression rate of p53 protein in patients with cervical lymph nodes metastasis(≥4cm)was 81.8%(9/11),in cervical lymph nodes metastasis (
5.Analysis laboratory results of three cases of COVID-19 complicated with falciparum malaria
ZHAO Rong ; SHI Ya-ling ; LIU Yan-xia ; JIANG Hong-ya ; FAN Yin-min ; ZHANG Zhan-feng
China Tropical Medicine 2023;23(1):106-
Abstract: Objective To analyze the laboratory indexes of patients infected with malaria patients and COVID-19, so as to provide reliable evidence for the diagnosis of mixed infection of both. Methods The routine clinical laboratory items such as routine blood, biochemistry and lymphocyte subsets were tested in three cases of COVID-19 complicated with falciparum malaria who admitted to Guangzhou Eighth People's Hospital Affiliated to Guangzhou Medical University from July to December 2020 were tested. Laboratory data were stage-wise analyzed in conjunction with changes in the course of disease. Results Three patients confirmed COVID-19 infection recruited all had malaria infection history. Fever, headache, and other symptoms emerged on the 4rd to 11th day after admission. Malaria parasite was detected by malaria parasite antigen testing and blood smear testing, and all three patients had re-ignition of malaria after being confirmed COVID-19 infection. In the early stage of malaria relapse, lymphocytes decreased, CRP and SAA increased, and gradually returned to normal level after antimalarial treatment. Interestingly, we only found one patient at the initial stage of malaria detection showed PLT decreased, no other unnormal changes in other routine blood results (WBC, ESO) and liver function results (ALT, AST, GGT, TBIL, DBIL, CG) were found from the beginning to end course of the disease. Conclusion COVID-19 infection may promote the resurgence of malaria, so the relapse of malaria should be monitored especially for the patient with malaria infection history who begin to develop fever and other symptoms a few days after the diagnosis of COVID-19. The inflammatory indicators would be worth able as an auxiliary judgment basis for the effective treatment of the two combined infection.
6. Research progress of oral anticoagulants in patients with liver diseases
Shipeng ZHAN ; Min TANG ; Fang LIU ; Peiyuan XIA
Chinese Journal of Hepatology 2018;26(11):873-876
Patients with liver disease are at an increased risk of both embolism and bleeding. The optimal anticoagulation strategy remains unclear when associated with venous thromboembolic disease. Moreover, currently approved oral anticoagulant drugs undergo metabolism and elimination in the liver with varying degrees of hepatic dysfunction. Thus, impaired liver function may lead to increased risk of bleeding, making anticoagulant therapy more intricate. This article summarizes the risk of bleeding and thrombosis in patients with liver disease, and the clinical research progress of oral anticoagulants in patients with liver disease to facilitate evidence for choosing oral anticoagulants therapy when required.
7.Investigation of etiology of massive infection with porcine pseudorabies virus in Henan and neighboring Provinces.
Hong-Tao CHANG ; Hui-Min LIU ; Zhan-Da GUO ; Ji-Mei DU ; Jun ZHAO ; Lu CHEN ; Xia YANG ; Xin-Wei WANG ; Hui-Xia YAO ; Chuan-Qing WANG
Chinese Journal of Virology 2014;30(4):441-449
In early 2011, the serious outbreak of porcine pseudorabies virus (PRV) infection suddenly recurred in Henan and neighboring Provinces. To investigate the etiology of massive infection with PRV, 16 800 serum samples, 905 porcine epidemic diarrhea virus (PEDV) back-feeding tissues, and 56 PR gene deleted live vaccines were colleted from January 2011 to May 2013 to detect PRV field infection using a PRV gE antibody test kit. The gE and TK genes of 11 new epidemic PRV strains were sequenced by PCR, and their molecular characteristics were analyzed. Moreover, virus titer determination, protective test against PRV, and vaccine potency testing were performed. The results showed that the detection rate of PRV field infection-positive pig farms was 68.06%, and the overall positive rate of PRV field infection in serum was 38.47%; the positive rates in breeding sows, breeding boars, reserve pigs, and commercial pigs were 40.12%, 30.88%, 54.67%, and 26.52%, respectively. The new epidemic strains were in the same evolutionary branch and belonged to the virulent strain group. Compared with the classical PRV strain, the virulence of new epidemic strains changed a little. The length of gE gene was 1 787 bp, and the length of TK gene was 963 bp. The nucleotide homologies of gE and TK genes to Chinese reference strains were 98.2%-99.8% and 98.90%-99.6%, respectively, and the amino acid homologies were 97.1%-99.8% and 97.5%-99.4%, respectively. Commercial vaccine had a 100% protective effect against the new epidemic strains. The positive rate of PRV field infection was 0% in vaccine and 40.44% in back-feeding tissues. The results confirmed that PRV field infection rates were rising sharply among pigs in Henan and neighboring Provinces after 2011. The main virulence genes of new epidemic PRV strains did not change significantly over the years. PR gene deleted live vaccines had no PRV field infection and could completely resist the attack of new strains. The virus carriage of breeding boars and reserve pigs and the serious PRV field infection in PEDV back-feeding tissues were the main causative factors for massive infection with PRV and epidemic outbreak in Henan and neighboring Provinces from 2011 to 2013.
Amino Acid Sequence
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Animal Feed
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analysis
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virology
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Animals
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China
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epidemiology
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Epidemics
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Female
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Herpesvirus 1, Suid
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chemistry
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classification
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genetics
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isolation & purification
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Male
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Molecular Sequence Data
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Phylogeny
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Pseudorabies
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epidemiology
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virology
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Sequence Alignment
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Sequence Homology, Amino Acid
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Sus scrofa
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Swine
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Swine Diseases
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epidemiology
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virology
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Viral Proteins
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chemistry
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genetics
8.Aortoesophageal fistula caused by descending aortic pseudoaneurysm: one case report.
Min XIA ; Ji-zhong GUO ; Qiang ZHAN ; Jie YAN
Chinese Medical Journal 2007;120(23):2149-2150
9.Effects of acupuncture on different acupoints in combination with rehabilitation on hemiplegic muscle spasticity in hemiplegia patients.
Jun-Yan LU ; Wen-Zhan TU ; Dan-Ying ZHENG ; Wen-Xia XIE ; Jin-Min LI ; Song-He JIANG
Chinese Acupuncture & Moxibustion 2010;30(7):542-546
OBJECTIVETo observe the clinical effect of hemiplegic muscle spasticity treated with acupuncture on different acupoints in combination with rehabilitation.
METHODSNinety cases of post-stroke muscle spasticity were randomized into a corresponding and central axis acupuncture group (group A), a conventional acupuncture group (group B) and a rehabilitation group (group C), 30 cases in each one. In group A, the acupoints on the Governor Vessel were mainly selected, as well as those on Hand-Shaoyang meridian and Foot-Taiyang meridian. In group B, the conventional needling and rehabilitation training were applied in combination, of which, the acupoints were mainly from Hand and Foot-Yangming meridians, associated with the acupoints of Shaoyang meridian. In group C, only rehabilitation training was applied. The assessments according to modified Ashworth scale and CSS score were performed before treatment, after 2 weeks and 4 weeks treatment respectively.
RESULTSThe level of modified Ashworth scale of the flexor of elbow and wrist was reduced apparently after treatment in group A as compared with that before treatment (P < 0.01). The level of modified Ashworth scale of the flexor of elbow was reduced apparently after treatment in group C as compared with that before treatment (P < 0.05). There was significant difference on the level change in modified Ashworth scale for the flexor of elbow between group A and group C after 4 weeks treatment (P < 0.05). CSS score decreased significantly in group A as compared with that before treatment (P < 0.01), the improvement after treatment in group A was apparent as compared with the other two groups (P < 0.01).
CONCLUSIONThe corresponding and central axis acupuncture can improve muscle tone of hemiplegic limb, which is superior to the effect achieved by the conventional acupuncture in combination with rehabilitation training and the simple rehabilitation training.
Acupuncture Points ; Acupuncture Therapy ; Aged ; Aged, 80 and over ; Female ; Hemiplegia ; rehabilitation ; therapy ; Humans ; Male ; Middle Aged ; Muscle Spasticity ; rehabilitation ; therapy ; Treatment Outcome
10.Numerical simulation study on effects of ambient temperature on airflow in the nasal cavity.
Guan-xia XIONG ; Jian-feng LI ; Wen-bin LEI ; Xu-hui ZHOU ; Jie-min ZHAN ; Geng XU
Chinese Journal of Otorhinolaryngology Head and Neck Surgery 2011;46(11):928-932
OBJECTIVETo study the aerodynamics of the normal human nasal cavity under different ambient temperatures.
METHODSBased on CT scanning, a model of a healthy adult's nasal cavity was established using computational fluid dynamics software from Fluent. Airflow in this model was simulated and calculated at ambient temperatures of 0 °C, 24 °C, and 37 °C during periodic breathing.
RESULTSAmbient temperature only had an impact on the temperature in the nasal cavity during the inspiratory phase, and the temperature distribution was not symmetrical in the inspiratory acceleration and deceleration phases. The ambient temperature significantly affected airflow speed in main nasal passages during the inspiratory process, but had little impact on flow status (proportion and streamline of airflow in different nasal passages). Temperature differences increased the irregular air movement within sinuses. The anterior nasal segment, including the area between the valve and the head of the middle turbinate, was the most effective part of the nasal airway in heating the ambient air.
CONCLUSIONSOur findings describe the effects of ambient temperature on airflow parameters in the nasal cavity within a single respiratory cycle. This data is more comprehensively and accurately to determine the relationship between nasal cavity aerodynamics and physiological functions.
Adult ; Air Movements ; Female ; Humans ; Models, Theoretical ; Nasal Cavity ; physiology ; Temperature