Objective:To study expression of lymphotoxin-?(LT-?)in SLE patients with the relationship of inordinate immunoregulation.Methods:The 82 SLE patients and 90 normal controls'serum concentration of LT-? protein was detected with ELISA and PBLs were separated for analyses of its encoding sequence with RNA spot hybridization.The polymorphisms of LT-? gene in PBLs were analyzed by PCR-RFLP.Results:The expressing level of LT-? in SLE patients was significantly higher than in controls for both seral protein and mRNA inPBLs(P

CpG oligonucleotide(CpG ODN)is a synthetic oligodeoxynucleotide containing non-methylated CpG,which has broad application prospects in disease prevention and clinical treatment. Among them,B class CpG ODN is widely used in vaccine research because of its strong immune stimulation and some motifs have entered the clinical research stage. At the same time,the problem of bacterial resistance in clinical treatment has become increasingly serious,and the development of bacterial vaccine with B class CpG ODN as adjuvant has become a research hotspot. This paper reviewed the current research status and related progress of the existing B class CpG ODN 1826,2006,2007 and 1668 motifs in bacterial vaccines,with a view to providing a reference for the subsequent development and application of bacterial vaccines.

No abstract available.
Appetite* ; Ghrelin* ; Growth Hormone*

No abstract available.
Appetite* ; Ghrelin* ; Growth Hormone*

?AIM: To investigate the compliance in patients with topical glaucoma therapy, and identify the most frequent barriers to adherence.?METHODS: One-on-one interview and questionnaire were taken to investigate the compliance with hypotensive eye drops in 366 patients who had been diagnosed as glaucoma and received the therapy for at least 6mo in Wuhan and suburban district from July 2014 to June 2015 in Wuhan Aier Eye Hospital.?RESULTS: The proportion of compliance was 44. 3%( 162/366 ) . Factors significantly influencing compliance included severity of the better eye, the severity of symptom when attacked, duration of medication and whether to administrate on the same time daily ( OR=5. 700,0. 554,0. 336,0. 558,P<0. 05). Age, gender, marital status, education level, economic status, domicile, knowledge of the disease, suffering from other diseases with medication, type of glaucoma, type of eye drop, frequency were not associated with a higher rate of non-compliance.? CONCLUSION: Compliance in patients with topical glaucoma therapy in Wuhan is poor. Regularly carrying out relevant health education and interventions is very important.

Abstract?AIM: To assess the efficacy and adverse reactions of two concentrations of diluted botulism toxin A ( BTX-A) for blepharospasm.?METHODS:Totally 220 patients (440 eyes) confirmedas blepharospasm in our department ( from January 2013 to January 2015 ) , were divided randomly into two groups:110 in high concentration group and 110 in low concentration group.The two groups were given local injections with 25 U/mL or 40 U/mL concentration of botulism toxin type A to the upper and lower eyelids orbicular muscle, corrugator, reducing eyebrow muscle and procerus respectively.We observed dosage of two groups, the treatment effect, the duration of the effect and the incidence of adverse reactions.?RESULTS: The high concentration group was given the BTX-A with 48.33 ±4.02U, the low concentration group was given the BTX-A with 28.51 ±3.42U,the differences were statistically significant( P<0.05).The differences of post-operative evaluation of curative effect, onset time and duration of the effect between the groups were not statistically significant ( P >0.05 ). Sixteen cases had ptosis in different levels in the high concentration group, and 2 in the low concentration group, the differences were statistically significant ( P<0.01).There were no serious complications such as intoxication, drug allergy in both groups.Ptosis relieved after using naphcon-A and disappeared in 2-3 wk.?CONCLUSION: The efficacy of local injection with two concentrations of diluted botulinum toxin A for blepharospasm was positive. Considering the high incidence of ptosis in high concentration group, we recommended the 25U/mL botulism toxin A for blepharospasm.

Insulin deficiency is a key factor involved in the pathogenesis of diabetes. Apoptosis is one of the reasons for the lose of islets. The whole process of apoptosis is quite complex. This article summarizes the role of several factors such as glucose, free fatty acid, GLP-1, and in the islets apoptosis.

OBJECTIVE:To discuss on the relationship between the research and development of new drugs and the global demands.METHODS:The demands of the world's drug market were discussed.The important issues in the research and development of the new drugs were analyzed and the thoughtful insights into these issues were put forward.RESULTS&CONCLUSION:The research and development should be aimed for drug variety,dosage form,the designs of package and label and drug registration in order to meet the demands of globalization.

OBJECTIVE:To explore a marketing mode that was in conformity with both market law and consumers'needs for health care products.METHODS:Problems in the marketing of health care products in China were overviewed and the causes were analyzed.RESULTS&CONCLUSION:The short-sighted behavior was a problem that couldn't be neglected in the development of health care products manufacturing businesses.A long-term development mechanism should be established ranging from brand accumulating,mode of marketing,product positioning to after-sale service and etc.

OBJECTIVE:To provide the reference for Chinese pharmaceutical industry in order to satisfy the global phar-maceutical market.METHODS:The development and manufacture of new drugs in today's world market were analyzed in the respect of advancement of technology,medical fee,drug consumption,transferring of research and development center,as well as the development of multinational enterprises.RESULT&CONCLUSION:Great importance should be attached to the development and manufacture of new drugs in today's world market in order to promote the development of Chinese phar-maceutical industry.