2.Linear angiokeratoma circumscriptum associated with hemangiectatic hypertrophy.
Min Seok SONG ; Yoo Deuk LEE ; Soo Il CHUN
Korean Journal of Dermatology 1991;29(4):544-548
No abstract available.
Angiokeratoma*
;
Hypertrophy*
3.The Role of CT and MR in Diagnosis of Aortic Dissection.
Koun Sik SONG ; Tae Hwan LIM ; Kwon Ha YOON ; Kyung Seok MIN ; Meong Gun SONG
Journal of the Korean Radiological Society 1994;31(6):1033-1038
PURPOSE: The purpose of this study was to determine the role of CT and MR imagings in the diagnosis aortic dissection and differentiation between the true and false lumen. MATERIALS AND METHODS: We retrospectively studied forty patients with aortic dissection(AD) diagnosed imagings or surgery. Of the forty patients, 19 were examined with only CT, 14 with CT and MR, and 7 with MI~: Our points of view were(1) the classification of AD according to configuration of intimal flap by cross-sectional imaging, (2) differentiation between the true and false lumens, (3) the course of the false lumen, and (4)! detectability of the origin of major branch vessels of the abdominal aorta. RESULTS: The classification by corss-sectional imaging were crescentic(65%), circumferential(15%), flat(12%), and irregular(8%) type, in which false negative diagnosis was made in 1 case of crescentic and circumferential type, respectively. In 2 case of flat type and 1 case of irregular type, the differentiation between the true and false lumen was impossible with CT. The course of the false lumen in descending thoracic aorta revealed countrclock wise rotation(66%), clockwise rotation(5%) or fixed(29%) apperance. MR imaging was superior to CT in the detection of the origin of major branch vessels of the abdominal aorta. The determination of the origin of major branches of abdominal aorta arising from the true and false lumen were impossible in 2 cases in which only CT was done. CONCLUSION: Diagnosis of crescentic and circumferential types of AD with narrow and thrombosed false lumen was problematic in both CT and MR with no difference of diagnostic accuracy between the two modalities. The differentiation between the true and false lumen was difficult in flat and irregular types with only CT. Therefore, when surgical treatment is considered as in type B aortic dissection, MR imaging is recommended in order to determine the origin of major branch vessels.
Aorta, Abdominal
;
Aorta, Thoracic
;
Classification
;
Diagnosis*
;
Humans
;
Magnetic Resonance Imaging
;
Retrospective Studies
4.Artificial Reproduction of Lupus Erythematosus by Provocative Phototesting.
Young Ho CHO ; Seung Kyung HANN ; Yoon Kee PARK ; Min Seok SONG ; Sungbin IM
Annals of Dermatology 1993;5(2):105-108
Sunlight is one of the well-established factors which play key roles in the induction and exacerbation of lupus erythematosus. In two patients of discoid lupus erythematosus, we have experimentally reproduced skin lesions by provocative phototesting. Both UVA (100 joules/cm²) and UVB (80 millijoules/cm²) radiation induced the skin lesions. The reproduced skin lesions were clinically and histopathologically consistent with lupus erythematosus.
Humans
;
Lupus Erythematosus, Discoid
;
Reproduction*
;
Skin
;
Sunlight
5.Childhood Viltiligo.
Seung Kyung HANN ; Min Seok SONG ; Yoon Kee PARK ; Sung Ku AHN
Annals of Dermatology 1991;3(2):112-118
We investigated the clinical aspect and immunologic parameters of childhood and adult vitiligo in our clinics and made a comparative study. The childhood vitiligo showed the following results : similar incidence of clinical patterns with adults except for the lower incidence of the acrofacial type than in adults ; less involvement in the extent of lesion of disease than in adults ; higher incidence of family history than with adults ; of the precipitating factors, trauma is the main one whereas emotional stress is for adults ; higher association with halo nevi than adults ; and lower incidence of serum autoantibodies than adults. We have ascertained that childhood vitiligo is a distinct subset of vitiligo, showing the above features which will be studied in more patients in a long term follow-up clinical study.
Adult
;
Autoantibodies
;
Clinical Study
;
Follow-Up Studies
;
Humans
;
Incidence
;
Nevus, Halo
;
Precipitating Factors
;
Stress, Psychological
;
Vitiligo
6.The activity of antimelanocyte autoantibodies in vitiligo patients.
Yoon Kee PARK ; Seung Kyung HANN ; Min Seok SONG ; Jung Ku YOON ; Hyung Il KIM
Korean Journal of Dermatology 1991;29(3):391-398
Several observation suggest that the antimelanocyte autoantibodies could play a role in melanocyte destruction. Some experiments indicate that melanocyte antibodies from patients with vitiligo can kill melanocyte in vitro. In these experiments, we demonstrated that vitiligo patient's sera containing antimelanocyte antibodies can lyse cultured human melanocytes by complement activation. Melanocyte cytotoxicity was measured using the ethidium bromide/ acridine orange viability assay. Significant melanocyte cytotoxicity was seen in sera from patients with both active and inactive vitiligo(p<0.01). Melanocyte cytotoxicity measured with complement-mediated cytotoxicity decreased after systemic steroid treatment(p<0.05) ; however melanocyte cytotoxicity showed no significant change with systemic PUVA therapy.
Acridine Orange
;
Antibodies
;
Autoantibodies*
;
Complement Activation
;
Ethidium
;
Humans
;
Melanocytes
;
PUVA Therapy
;
Vitiligo*
7.Expression of extracellular martix genes in scleroderma fibroblast cultures.
Kyu Suk LEE ; Seok Ju KIM ; Min Ho SUH ; Joon Young SONG
Korean Journal of Dermatology 1991;29(3):322-330
Scleroderma is a connective tissue disease characterized by excessive accumulation of collagen in skin and visceral organs due to increased collagen production by scleroderma fibroblasts. The basic etiology of this collagen accumulation is not known. We examined the expression of various extracellular matrix genes in cultured fibrolasts using Northern blot and slot-blot hybridization. The scleroderma fibroblasts exhibited characteristic mRNA size of extracellular matrix genes and prominanty increased type I and III procollagen mRNAs levels compared to control fibroblasts cultures from univolved skin. The ratios of type I /IE procollagen in scleroderma cell lines were not so much different to the controls. These results indicate that increases of collagen biosynthesis in scleroderma can be a accounted for, at least in part, by an increased content of transcriptable type I and type JE procollagen mRNAs, both.
Blotting, Northern
;
Cell Line
;
Collagen
;
Connective Tissue Diseases
;
Extracellular Matrix
;
Fibroblasts*
;
Procollagen
;
RNA, Messenger
;
Skin
8.The electron microscopic changes of the mucosa of fallopian tubes after surgical sterilization.
Chan Ho SONG ; Jung Min KANG ; Young Wook YOON ; Byung Seok LEE ; Ki Hyun PARK
Korean Journal of Obstetrics and Gynecology 1993;36(7):1139-1145
No abstract available.
Fallopian Tubes*
;
Female
;
Mucous Membrane*
;
Sterilization*
9.Three cases of subcutaneous sarcoidosis.
Min Seok SONG ; Hee Weon PARK ; Soo Il CHUN ; Yoon Kee PARK
Korean Journal of Dermatology 1991;29(1):109-113
We report herein three cases of subcutaneous sarcoidosis without apparent internal lesion. The patients had multiple subcutaneous nodules on the extremities and abdomen. Hyper-gammaglobulinemia, a relative increase of T suppressor cells, and increased serum angiotensin converting enzyme level and skin anergy were observed. Histopathologic findings revealed sarcoidal granulomas involving the subcutaneous fat tissue. The lesions of two cases resolved spontaneously and the other one case required systemic corticosteroid therapy.
Abdomen
;
Extremities
;
Granuloma
;
Humans
;
Peptidyl-Dipeptidase A
;
Sarcoidosis*
;
Skin
;
Subcutaneous Fat
10.The Effect of Systemic PUVA on the Proliferation of Melanocytes and the Titer of Anti - Pigment Cell Autoantibodies in Vitiligo Patients.
Seung Kyung HANN ; Hang Kye SHIN ; Min Seok SONG ; Yoon Kee PARK
Korean Journal of Dermatology 1997;35(1):57-70
BACKGROUND: PUVA has been used effectively in the treat,ment of vitiligo, but the mechanism by which PUVA stimulat.es melanocyte proliferation in vitiligo is not known. Several mechanisms have been suggested to be involved in the process of repigmentation of vitiligo. First, UV light, with or without psoralen, directly stimulates the proliferation of melanocytes. Secondly, PUVA may act. on epidermal keratinocytes or dermal components to stimulate t,hem to release certain melanocyte growth st,inulation factors that enhance the proliferation of melanocytes in depigmented lesions. Thirdly, PUVA irnmunologically leads to the impairment of epidermal Langerhans cell function and alteration of circulating T and B cell function, which results in the suppression of the stimuli is for rnelanocyte destruction during the therapy. OBJECTIVE: To test, th hypothesis that PUVA induced repigmentation in vitiligo results from the stimulation of growth factors that induce melanocyte proliferation, and that PUVA may suppress the immune reacticin to melanocytes, especially in autoantibody synt,hesis, we examined the effects of sera on the growth of epidermal melanocytes and control cells, and t,he incidence of antibodies to melanocyte and melanoma cells(SK-Mel 2~3) in the sera of patients with vitiligo. We also had normal control individuals and studied the changes of the antibody titer in the sera of patients with vitiligo. METHODS: The rate of H thymidine uptake was estimat,ed in cultured melanocytes and fibroblasts t,reated by patients sera before and after PUVA treatment. SDS-PAGE and immunoblotting analysis were used to idcntify anti pigment cell autoantibodies and were compared to the titers of autoantibodies after PUVA. RESULTS: 1. Melanocyte and fibrablast proliferation was increased by PUVA treated sera. Their proliferation was in proportion to the duration of the PUVA treatment. Melanocytes proliferated more than fibroblasts. 2. Significant differences between vitiligo patients and normal controls were found in the inci dence of anti-pigment cell antibodies. The antibodies were predominantly directed to melanocyte antigens of 110 kD, 65 kD, 45 kD and melanoma cell antigens of 110 kD, 103 kD, 88kD, 70 kD, 56 kD, 41 kD. 3. The titer of anti piment cell antibodies showed a tendency to decrease after PUVA treat- ment in most patients regardless of clinical improvement. Conclusion ; PUVA treated sera induced proliferation of melanocytes and fibroblasts and the production of aut,oantibodies was suppressed against pigment cell antigens through irnmunosuppression, which might help in the repigmentation of vitiligo.
Antibodies
;
Autoantibodies*
;
Electrophoresis, Polyacrylamide Gel
;
Fibroblasts
;
Ficusin
;
Humans
;
Immunoblotting
;
Incidence
;
Intercellular Signaling Peptides and Proteins
;
Keratinocytes
;
Melanocytes*
;
Melanoma
;
Thymidine
;
Ultraviolet Rays
;
Vitiligo*