1.Study on Effect of Omeprazole on Therapy and Prophylaxis for Stress Ulcer in Children with Epidemic Type B Encephalitis
Journal of Applied Clinical Pediatrics 1986;0(01):-
Objective To investigate the safety,therapy and prophylactic effect of Omeprazole on stress ulcer in children with epidemic type B encephalitis.Methods Before and after medication,chest X-ray examination was performed.The result of occult blood(OB) was confirm by Colloidal gold assay in stool and/or gastric juice.Based on the result of OB,the patients were divided into therapy group[besides conventional therapy for encephalitis,Cimitidine group and Omeprazole group with positive result OB,was administered with 0.9% normal sodium 100 mL+Cimitidine 20-40 mg/(kg?d),iv,q12 h and normal sodium 100 mL+Omeprazol 0.5-0.8 mg/(kg?d),iv,qd,respectively] and prophylaxis group(Cimitidine group,Omeprazole group and control group,with negative result OB,were administered with same medicines as therapy group,respectively.Except control group being administered only 0.9%NS 100 mL,iv,(q12 h)).The effects of drugs on hemostasis,preventing hemorrhage,and the potential risk of acquired pneumonia result from drugs used were observed.Results In therapy group,the average time of hemostasis in Omeprazole group was obviously shorter than that of in Cimitidine group,there was significant difference between two groups(P0.05).Conclusions Both of the drugs is safety and effect to therapy or prophylaxis for the latent stress ulcer in short term.The effect of Omeprazole is better than those of Cimitidine.Using Cimitidine and Omeprazole,neither therapy nor prophylaxis for stress ulcer increaseds the potential risk of acquired pneumonia in children with epidemic type B encephalitis in this study.
2.Pathological analysis of pancreatic colloid carcinoma in 7 cases.
Xia MIN ; Ji-zhong GUO ; Qiang ZHAN
Chinese Journal of Oncology 2007;29(5):377-378
Adenocarcinoma, Mucinous
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metabolism
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pathology
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surgery
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Aged
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Biomarkers, Tumor
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metabolism
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Carcinoembryonic Antigen
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metabolism
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Carcinoma, Pancreatic Ductal
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metabolism
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pathology
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surgery
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Carcinoma, Papillary
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metabolism
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pathology
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surgery
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Cystadenocarcinoma, Mucinous
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metabolism
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pathology
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surgery
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Diagnosis, Differential
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Duodenal Neoplasms
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metabolism
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pathology
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surgery
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Female
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Follow-Up Studies
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Humans
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Immunohistochemistry
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Male
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Middle Aged
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Mucin-2
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Mucins
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metabolism
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Neoplasm Invasiveness
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Pancreatic Neoplasms
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metabolism
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pathology
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surgery
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Pancreaticoduodenectomy
3.Effect of Paeonol on PGI2,TXA2,ET and NO in Diabetic Rats
Cunyun MIN ; Heqiang LIU ; Feng ZHAN
Chinese Journal of Information on Traditional Chinese Medicine 2006;0(12):-
Objetive To study the effect of Paeonol on PGI,TXA2,ET and NO in diabetic rats.Methods Streptozocin was used in dosage of 60 mg/kg on rats to make diabetic animal model.Defferent dosages of Paeonol were used on diabetic animal models.6-Keto-PGF1?,TXB2,ET and NO were tested after 30 days. Results Compared to the control group,6-Keto-PGF1?(pg/mL)of Paeonol groups increased from 89.75? 2.75,89.97?7.28,89.97?11.36 to 120.03?13.85,108.34?11.25,105.32?8.85 respectively;TXB2 (pg/mL)decreased from 157.64?10.36,156.64?11.35,153.33?19.40 to 124.46?18.67,136.40?18.15, 138.40?22.20 respectively;ET(pg/mL)decreased from 181.68?5.10,181.27?4.76,181.04?4.19 to 140.55?3.01,150.51?2.22,161.02?3.76.The change of 6-Keto-PGF1?,TXB2 and ET was related to the dosage of Paeonol.NO has no significant change.Conclusions Paeonol can decrease the ET and TXB2 in diabetic rats,and increase 6-Keto-PGF1?in diabetic rats.
4.Gadd45a Function in Suppressing Cell Transformation and Tumor Malignancy
Junfang JI ; Min WU ; Qimin ZHAN
Progress in Biochemistry and Biophysics 2006;0(12):-
Gadd45a, a p53 and BRCA1-regulated growth arrest and DNA damage gene, plays important roles in suppressing cell transformation and tumor malignancy. Gadd45a maintains the genomic stability through inhibiting the cell growth and promoting the DNA repair etc, by which it suppresses the tumor development. Additionally, Gadd45a is involved in some important signaling pathway, contributing to its function in tumor suppressing.
5.Effect of constant magnetic field on metal ion Co~(2+),Cr~(3+) induced TNF-? secreted by human mononuclear cells
Min DAI ; Jianwei XIONG ; Ping ZHAN
Orthopedic Journal of China 2006;0(07):-
[Objective]To detect the effect of constant magnetic field on metal ion Co2+,Cr3+ induced TNF-? secreted by human mononuclear cells,and to search a method for prevention and treatment of aseptic loosening. [Methods]CoCl2 powder and CrCl3 powder were dissolved in the asepsis injecting water. Mononuclear cells from human peripheral blood,were taken and cultured with Co2+,Cr3+ ions in different magnetic field of 10Gs,100 Gs,1000Gs for 12,24 and 48 hs. There were nine groups:control group,Co2+ group,Cr3+ group,Co2+andCr3+ with various intensities of constant magnetic field,respectively.ELISA method was applied to detect tumor necrosis factor (TNF-?) in serum via the absorbance (A).[Results]Co2+ and Cr3+ ions stimulated human mononuclear cell to secrete TNF-? (P
6.Advances in research on inhibitors based on targets: IDO1 and TDO
Acta Pharmaceutica Sinica 2021;56(5):1265-1278
Indoleamine 2,3-dioxygenase 1 (IDO1) and tryptophan 2,3-dioxygenase (TDO) catalyze the initial and rate limiting step in the catabolism of tryptophan, which is related to tumor immune tolerance and poor prognosis in patients. In this regard, two enzymes have become important therapeutic targets for tumor immunotherapy. So far, nine IDO1 inhibitors and three IDO1/TDO dual inhibitors have entered clinical trials. This review summarizes the research progress of IDO1 inhibitors, TDO inhibitors and IDO1/TDO dual inhibitors from the perspective of medicinal chemistry.
7.Investigation of properties of the resveratrol-beta-cyclodextrin inclusion complex by drug-protein interaction spectra and molecular modeling.
Ming GUO ; Min-Zhong ZHAN ; Yan-Ke JIANG
Acta Pharmaceutica Sinica 2014;49(5):726-733
The supramolecular inclusion properties of beta-cyclodextrin (beta-CD) and resveratrol (Res) were investigated using drug-protein interaction spectroscopy method. The differences between the results of interaction spectroscopy method and the results of classical method were compared. The total energy of the stable inclusion of cyclodextrin-resveratrol was calculated by Gaussian theory calculation. The stable inclusions in the process of interaction between resveratrol/inclusion complex and bovine lactgoferrin (BLF) were studied by molecular modeling. The results showed that the interaction spectroscopy method could explain the property of the inclusion in a more sensitive manner, it also interpreted the conveying mechanism of BLF binding with inclusion complex. The molecular modeling result showed consistent results with Gaussian theory calculation; both of the two methods obtained the stable configuration of beta-CD-Res inclusion. The relevant result provided an experimental consequence for the pharmacology research of beta-cyclodextrin-resveratrol inclusion complex as well as offering a new reference to the future research of supramolecular inclusion compound.
Animals
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Cattle
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Lactoferrin
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chemistry
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Magnetic Resonance Spectroscopy
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Models, Molecular
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Stilbenes
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chemistry
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beta-Cyclodextrins
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chemistry
8.Compiling textbooks to reform the paper writing course for Chinese medical postgraduates
Rongxia LIAO ; Xiaoqing ZHAN ; Xuejiao TAN ; Jianguo SUN ; Min CHEN
Chinese Journal of Medical Education Research 2015;(1):74-77
As a new interdisciplinary course, the current paper writing course for medical postgraduates exhibits certaln disadvantages. For example, the course does not well target the learners' needs because of the absence of the needs analysis before class;English or biomedical teachers fall to combine English with medicine, thus unable to provide ideal courses. As textbooks are an important means to improve the quality of the course, one way to reform the course is to compile high-quality textbooks by interdisciplinary talents. Meanwhile, the compiling process should be guided by needs analysis as well as the teaching and editing experiences. In addition, the textbooks need to be con-tinuously improved in teaching practice.
9.Histomorphometric evaluation of ridge preservation after molar tooth extraction
Yalin ZHAN ; Wenjie HU ; Tao XU ; Min ZHEN ; Ruifang LU
Journal of Peking University(Health Sciences) 2017;49(1):169-175
Objective:To evaluate bone formation in human extraction sockets with absorbed surrounding walls augmented with Bio-Oss(R) and Bio-Gide(R) after a 6-month healing period by histologic and histomorphometric analyses.Methods:Six fresh molar tooth extraction sockets in 6 patients who required periodontally compromised moral tooth extraction were included in this study.The six fresh extraction sockets were grafted with Bio-Oss(R) particle covered with Bio-Gide(R).The 2.8 mm × 6.0 mm cylindric bone specimens were taken from the graft sites with aid of stent 6 months after the surgery.Histologic and histomorphometric analyses were performed.Results:The histological results showed Bio-0ss(R) particles were easily distinguished from the newly formed bone,small amounts of new bone were formed among the Bio-Oss(R) particles,large amounts of connective tissue were found.Intimate contact between the newly formed bone and the small part of Bio-Oss(R) particles was present.All the biopsy cylinders measurement demonstrated a high inter-individual variability in the percentage of the bone,connective tissues and BioOss(R) particles.The new bone occupied 11.54% (0-28.40%) of the total area;the connective tissues were 53.42% (34.08%-74.59%) and the Bio-Oss(R) particles were 35.04% (13.92%-50.87%).The percentage of the particles,which were in contact with bone tissues,amounted to 20.13% (0-48.50%).Conclusion:Sites grafted with Bio-Oss(R) particles covered with Bio-Gide(R) were comprised of connective tissues and small amounts of newly formed bone surrounding the graft particles.
10.Progress in biotransformation of triptolides and bufadienolides
Min YE ; Lili NING ; Jixun ZHAN ; Hongzhu GUO ; Dean GUO ;
Journal of Peking University(Health Sciences) 2004;0(01):-
The latest results from our research group in the biotransformation of triptolides and bufadienolides were reviewed. The trends in the development of biotransformation in the future were also briefly discussed.