No abstract available.
Syringoma*

Background: Rosacea is a common inflammatory skin disease with multiple etiologies.Proton pump inhibitors (PPIs) and histamine-2 receptor antagonists (H2RA) are acid suppressive drugs widely used for gastrointestinal (GI) diseases, and long-term use has been reported to be associated with dysbiosis which is a potential risk for development of rosacea. This study aimed to study the association between rosacea and acid suppressants in the Korean national cohort. Methods: We used Korean National Health Insurance Service-National Sample Cohort data of 749,166 patients with upper GI diseases between 2001 and 2013. Duration of acid suppressants was compared between patients with and without rosacea together with other sociodemographic characteristics and hazard ratios were estimated. Results: Longer use of acid suppressants was significantly associated with increased risk of rosacea. After adjustment for possible confounders, increased cumulative defined daily dose was significantly associated with risk of rosacea (odds ratio [OR], 1.55; 95% confidence interval [CI], 1.20–2.00; P = 0.001). Other factors significantly associated with risk of rosacea include residing in the rural area (OR, 2.58; 95% CI, 2.18–3.06; P < 0.001), greater Charlson Comorbidity Index score (OR, 1.45; 95% CI, 1.15–1.83; P = 0.002), and comorbidities (malignancy, thyroid disease, and depression). Conclusion Results from our study indicate that H2RA or PPI is associated with the occurrence of rosacea among patients with GI diseases in the Korean population. The risk was increased in dose-dependent manner, even after adjusting for confounding variables.Clinicians should be aware of risks associated with prolonged use of acid suppressive drugs.

Verrucous carcinoma is an uncommon low-grade variant of squamous cell carcinoma. It is clinically characterized by its verrucous and fungating appearance and it is histologically characterized by well-differentiated epithelial proliferations that push the underlying dermis. There are some reports of verrucous carcinoma associated with abscess or fistula, but there have been no case reports of verrucous carcinoma complicated with a subcutaneous abscess involving the adjacent tissue in Korea. We report here on a case of verrucous carcinoma that presented with focal verrucous nodule infiltrating the adjacent subcutaneous tissue with diffuse subcutaneous abscess formation.
Abscess ; Buttocks ; Carcinoma, Squamous Cell ; Carcinoma, Verrucous ; Dermis ; Fistula ; Korea ; Subcutaneous Tissue

PURPOSE: The purpose of this study was to investigate the health status and nutritional condition of children living in a low-income community through anthropometric, laboratory evaluation. METHODS: A community-based survey identified children below 15 years living in a low-income community. Their weight, height, visual acuity, hearing level and dental status were measured. Blood sample were obtained on June and July, 2004. Hemoglobin, serum cholesterol, Hepatitis B antigen/antibody, AST and ALT were measured. RESULTS: A total of 285 students(M:F=141:144) aged 6 to 14 years were included in this study. The heights and weights in some grades were smaller than controls. The prevalence of obesity was 10.6 percent in males and 10.7 percent in females. The prevalence of abnormal visual acuity, hearing impairments and dental carries were 20.5 percent, 0.3 percent and 69.4 percent. The prevalence of anemia was 10.1 percent. Serum total cholesterol was over 200 mg/dL in 7 percent. They complained of abdominal pain(22.1 percent) and headache(17.1 percent). Hyperthyroidism, cataract, neurofibromatosis, severe atopic dermatitis, ventricular septal defect, strabismus and inguinal hernia were newly diagnosed. CONCLUSION: Mean heights and weights of children in the low-income community were smaller than controls. The prevalence of abnormal visual acuity, hearing impairment and dental carries were higher than in the 2003 national health survey. Additional research is needed to evaluate the health status of the low-income community.
Anemia ; Cataract ; Child* ; Cholesterol ; Dermatitis, Atopic ; Female ; Health Surveys ; Hearing ; Hearing Loss ; Heart Septal Defects, Ventricular ; Hepatitis B ; Hernia, Inguinal ; Humans ; Hyperthyroidism ; Male ; Neurofibromatoses ; Obesity ; Prevalence ; Strabismus ; Visual Acuity ; Weights and Measures

Neurologic manifestations rarely occur as presenting feature of systemic lupus erythematosus (SLE). We describe two women who presented with several episodes of neurologic symptoms mimicking multiple sclerosis. Several years after disease onset, clinical and laboratory finding were compatible with SLE. These cases show that demyelinating syndrome resembling multiple sclerosis may present as a first manifestation of SLE.
Female ; Humans ; Lupus Erythematosus, Systemic* ; Multiple Sclerosis* ; Neurologic Manifestations

Vocal cord dysfunction is a recently described entity in which paradoxical adduction of the vocal cords produces airflow obstruction at the level of the larynx. Recurrent wheezing results, which may imitate asthma. Inspiratory closure of the cords can also cause stridor, commonly misdiagnosed as an upper airway obstruction of undefined cause. The acute presentation is often dramatic and has led to inappropriate treatment, including intubation, tracheotomy, or high doses of steroids. We present the case of a 9 yr old boy with allergic rhinitis who was referred to us for the evaluation of wheezing and dyspnea which did not respond to asthma management. Pulmonary function tests had abnormal inspiratory phases and laryngoscopy revealed typical adduction of the vocal cord during inspiration. Psychological tests suggested anxiety and tension with repressed aggression. There have been no further episodes, possibly due to counseling and education of relaxed throat breathing as well as avoidance of inhaled medication.
Aggression ; Airway Obstruction ; Anxiety ; Asthma ; Counseling ; Dyspnea ; Education ; Humans ; Intubation ; Laryngoscopy ; Larynx ; Male ; Pharynx ; Psychological Tests ; Respiration ; Respiratory Function Tests ; Respiratory Sounds ; Rhinitis ; Spirometry ; Steroids ; Tracheotomy ; Vocal Cord Dysfunction* ; Vocal Cords*

Urticarial vasculitis is characterized clinically by urticarial skin lesions and histologically by leukocytoclastic vasculitis. Hypocomplementemic urticarial vasculitis is associated with connective tissue diseases such as systemic lupus erythematosus (SLE). We report a case of urticarial vasculitis that preceded manifestations of SLE.
Anti-Infective Agents/therapeutic use ; Anti-Inflammatory Agents/therapeutic use ; Diagnosis, Differential ; Female ; Humans ; Lupus Erythematosus, Systemic/*diagnosis/etiology/pathology ; Middle Aged ; Recurrence ; Skin/pathology ; Urticaria/complications/*diagnosis ; Vasculitis, Hypersensitivity/complications/*diagnosis/pathology

The conventional approach to treatment of patients with ankylosing spondylitis (AS) have been rather limited in the last decades. Evidence is accumulating that tumor necrosis factor (TNF) blocker is highly effective in AS. This article reviews the most recent and the most pertinent advances in the treatment in AS. TNF blocker have been evaluated in a number of randomized controlled trials in AS and have been demonstrated to be effective in disease activity, function, and quality of life in these patients. TNF blocker is emerging as the best therapeutic option available for patients with AS.
Humans ; Quality of Life ; Spondylitis, Ankylosing* ; Tumor Necrosis Factor-alpha

Acute generalized exanthematous pustulosis (AGEP) is an uncommon aseptic pustular eruption that usually follows recent administration of oral or parenteral drugs. Characteristic AGEP features include the sudden onset of fever with widespread erythematous eruption, rapidly progressing to a fine, non-follicular, micropustular rash. The illness usually resolves spontaneously with fever and pustulation clearing within 15 days, sometimes followed by desquamation. Histopathology shows non-follicular spongiotic pustules in the epidermis filled with neutrophils, a mixed perivascular infiltrate of neutrophils and occasional eosinophils with papillary dermal edema. We describe a 10-month-old boy with AGEP secondary to exposure to amoxicillin. This is an uncommon condition in children.
Acute Generalized Exanthematous Pustulosis ; Amoxicillin ; Child ; Drug Eruptions ; Edema ; Eosinophils ; Epidermis ; Exanthema ; Fever ; Humans ; Infant ; Neutrophils