1.A Case of Resection of Pulmonary Metastatic Choriocarcinoma in Drug-Resistant Patient.
Ji Min LEE ; Chi Heum CHO ; Soon Do CHA ; Sang Min CHO ; Kun Young KWON
Korean Journal of Obstetrics and Gynecology 2000;43(6):1096-1099
Pulmonary metastasis occurs frequently in patients with gestational choriocarcinoma and most of these patients achieve remission with chemotherapy alone. Thus, the indications for surgical intervention are limited, but in appropriately selected patients, resection of a chemotherapy-resistant lung lesion can be curative. We have experienced that pulmonary metastatic choriocarcinoma in a drug-resistant patient was cured by pulmonary resection. So we report this case with a brief review of literatures.
Choriocarcinoma*
;
Drug Therapy
;
Female
;
Humans
;
Lung
;
Neoplasm Metastasis
;
Pregnancy
2.The Virulence Factors of Vibrio spp.
Yang Hyo OH ; Young Min PARK ; Min Jung KIM ; Mi Sun CHA
Journal of the Korean Society for Microbiology 1999;34(2):125-136
A total of 100 Vibrio spp. strains were examined for production of various extracellular enzyme and for plasmid content plasmid were subjected to digestion with restriction enzymes. Most of them produced extracellular enzyme more than one, especially V. parahaemolyticus and V. cholerae non-01 strains were showed production of various extracellular enzymes. About the 55% Vibrio spp. have the plasmid more than one, but a lot of Vibrio spp. (about 45%) did not possess any plasmid. Most of these plasmid various derivatives ranged from 2.4 kb-23 kb, especially two strains of V. mimicus and one strain of V. furnissii carried one high-molecular weight plasmid (molecular weight ranging between 70 kb-100 kb). Results of restriction analysis for plasmid of this three strains were by no means the rule. For detection of tdh and ctx gene, the virulence factor involved in the pathogenesis, we carried out the TDH, CT assay, PCR amplification, and hybridization. A total 11 strains were produced TDH, involved in 4 strains of V. parahaemolyticus and 1 strain of V. cholerae non-01 from clinical isolates and 6 strains of environmental isolates. Nine strains of 11 strains, involved in 4 strains of V. parahaemolyticus and 1 strain of V. cholerae non-01 from clinical isolates and 4 strains of V. parahaemolyticus from environmental isolates, could be successfully amplified in 400 bp by PCR, no amplification products were obtained from TDH-negative strains. The PCR results were consistent with DNA hybridization. In the experiments of ctx gene detection, in all, 3 strains of V. cholerae non-01 from clinical isolate and 1 strains of V. cholerae non-01 from environmental isolate were observed CT- positive. These CT-producing strains amplified in 302 bp by PCR for the detection of ctx gene. All CT-producing strains hybridized with digoxigenin-labeled DNA probe, while CT-negative strains did not hybridize. Also hybridization tests results for detection of ctx gene consistent with PCR.
Cholera
;
Digestion
;
DNA
;
Plasmids
;
Polymerase Chain Reaction
;
Vibrio*
;
Virulence Factors*
;
Virulence*
3.Clinical study of color doppler ultrasonography in IVF-ET.
Young Beom CHA ; Hong Ki KIM ; Seung Jae LEE ; Jong Min PARK ; Young Ho LEE
Korean Journal of Obstetrics and Gynecology 1991;34(5):697-704
No abstract available.
Ultrasonography, Doppler, Color*
4.Epidural Emphysema Associated with Subcutaneous Emphysema after Chest Tube Placement: A Case Report.
Ji Young RHO ; Seung Min YOO ; Young Ah CHO ; Sang Min LEE
Tuberculosis and Respiratory Diseases 2010;69(5):389-391
Spinal epidural emphysema is rare and has been described secondary to following medical intervention, such as lumbar puncture and epidural analgesia, pneumothorax or pneumomediastinum, degenerative disk disease, epidural abscess, and trauma. Rarely, it occurs after chest tube placement. We report a case of spinal epidural emphysema incidentally noted on HRCT after chest tube placement.
Analgesia, Epidural
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Chest Tubes
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Emphysema
;
Epidural Abscess
;
Epidural Space
;
Mediastinal Emphysema
;
Pneumothorax
;
Spinal Puncture
;
Subcutaneous Emphysema
;
Thorax
;
Tomography, X-Ray Computed
5.Liquid Biopsy: Current Status and Future Perspective in Gastric Cancer and Helicobacter Infection.
Eun A KANG ; Young Min HAN ; Jong Min PARK ; In Kyung YOO ; Sung Pyo HONG ; Ki Baik HAHM
The Korean Journal of Helicobacter and Upper Gastrointestinal Research 2018;18(3):150-156
Precision medicine stands for 4Ps - precise, preventive, participatory, and personal; in which “precision” is important because the current modern medicine starts from “trial and error,” and “one does not fit all”. Current targeted therapies for cancer have changed treatment approaches and led the precision medicine; however, clinical use of liquid biopsy, using blood or other liquid specimens to characterize circulating tumor cells (CTC) or tumor genes instead of biopsies of tumor tissues, still awaits availability of more information regarding non-invasive cancer detection and characterization, prediction of treatment response, monitoring the disease course and relapse possibilities, identification of mechanisms of drug resistance, and newer pathogenesis. In this review, we will introduce the basic concept of CTC, circulating cell free DNA, and exosomes and their possible application for gastric cancer relevant with Helicobacter pylori infection.
Biopsy*
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DNA
;
Drug Resistance
;
Exosomes
;
Helicobacter Infections*
;
Helicobacter pylori
;
Helicobacter*
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History, Modern 1601-
;
Humans
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Neoplastic Cells, Circulating
;
Precision Medicine
;
Recurrence
;
Stomach Neoplasms*
6.Risk of Subsequent Primary Cancers in Thyroid Cancer Survivors according to the Dose of Levothyroxine: A Nationwide Cohort Study
Min-Su KIM ; Jang Won LEE ; Min Kyung HYUN ; Young Shin SONG
Endocrinology and Metabolism 2024;39(2):288-299
Background:
Current research has not investigated the effect of thyroid-stimulating hormone suppression therapy with levothyroxine on the risk for developing subsequent primary cancers (SPCs). This study aimed to investigate the association between levothyroxine dosage and the risk for SPCs in thyroid cancer patients.
Methods:
We conducted a nationwide population-based retrospective cohort study form Korean National Health Insurance database. This cohort included 342,920 thyroid cancer patients between 2004 and 2018. Patients were divided into the non-levothyroxine and the levothyroxine groups, the latter consisting of four dosage subgroups according to quartiles. Cox proportional hazard models were performed to evaluate the risk for SPCs by adjusting for variables including cumulative doses of radioactive iodine (RAI) therapy.
Results:
A total of 17,410 SPC cases were observed over a median 7.3 years of follow-up. The high-dose levothyroxine subgroups (Q3 and Q4) had a higher risk for SPC (adjusted hazard ratio [HR], 1.14 and 1.27; 95% confidence interval [CI], 1.05–1.24 and 1.17– 1.37; respectively) compared to the non-levothyroxine group. In particular, the adjusted HR of stomach (1.31), colorectal (1.60), liver and biliary tract (1.95), and pancreatic (2.48) cancers were increased in the Q4 subgroup. We consistently observed a positive association between high levothyroxine dosage per body weight and risk of SPCs, even after adjusting for various confounding variables. Moreover, similar results were identified in the stratified analyses according to thyroidectomy type and RAI therapy, as well as in a subgroup analysis of patients with good adherence.
Conclusion
High-dose levothyroxine use was associated with increased risk of SPCs among thyroid cancer patients regardless of RAI therapy.
7.Three cases of atypical Kawasaki disease with coronary aneurysm.
Min Young PARK ; Kwang Sun HAN ; Sung Yoon CHO ; Byoung Soo CHO ; Sung Ho CHA
Journal of the Korean Pediatric Society 1993;36(9):1315-1319
Kawasaki disease is described by fever lasting five days or more, bilateral conjunctival injection, changes of lips and oral cavity, polymorphous exanthema, acute non-purulent cervical lymphadenopathy, and changes of extremities. Atypical Kawasaki disease is defined as fewer than 4 of 6 criteria described above including coronary artery abnormalities. Especially, atypical clinical manifestations of Kawasaki disease appear in infants younger than 6 months old of age. Thus we recommend echocardiography in early infancy who has prolonged fever in order to diagnose atypical Kawasaki disease and treat early. We have experienced three cases of atypical Kawasaki disease with coronary aneurysm who were admitted because of fever and revealed coronary aneurysm on echocardiography.
Coronary Aneurysm*
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Coronary Vessels
;
Echocardiography
;
Exanthema
;
Extremities
;
Fever
;
Humans
;
Infant
;
Lip
;
Lymphatic Diseases
;
Mouth
;
Mucocutaneous Lymph Node Syndrome*
8.A Case of Renal Tuberculosis in a Child.
Min Young CHA ; Se Yun EUN ; Chong Guk LEE ; Sang Il LEE ; Sang Woo KIM
Journal of the Korean Pediatric Society 1984;27(7):733-737
No abstract available.
Child*
;
Humans
;
Tuberculosis, Renal*
9.A Case of Acute Lymphocytic leukemia in a Newborn.
Young Jin MIN ; Myoung Hee CHA ; Kyeng Sook CHO ; Jong Dai JO
Journal of the Korean Pediatric Society 1988;31(9):1197-1201
No abstract available.
Humans
;
Infant, Newborn*
;
Precursor Cell Lymphoblastic Leukemia-Lymphoma*
10.A Clinical Review of Intussusception in Infant and Children.
Myeong Hee CHA ; Young Jin MIN ; Kyeong Sook CHO ; Jong Dae CHO
Journal of the Korean Pediatric Society 1988;31(9):1153-1162
No abstract available.
Child*
;
Humans
;
Infant*
;
Intussusception*