Objective To investigate the electrophysiology mechanism of the P wave dispersion (Pd) and the maximum P wave duration (Pmax) in patients with paroxysmal atrial fibrillation (PAF),and evaluate the effect of the Pd and Pmax in the prediction of PAF. Methods Forty-eight patients with PAF (group PAF) were slected and divided into 2 sub-groups according to the organic heart disease,group PAF1 (20 cases, without organic heart disease) and group PAF2 ( 28 cases, with organic heart disease). Forty-six patients without PAF were selected as control group. The Pd and Pmax were measured from the 12-lead surface electrocardiogram (ECG). Results The Pd and Pmax in group PAF was higher than that in control group [(41.11 ± 4.97 ) ms vs. (27.77 ± 4.72) ms, ( 111.43 ± 8.01 ) ms vs. (95.57 ± 9.01 ) ms] (P ＜ 0.05 ). The Pmaxin group PAF2 was significantly higher than that in group PAF1 (P ＜ 0.05),and there was no significant difference in the Pd between group PAF2 and group PAF1 (P＞ 0.05 ). The specificity, sensitivity and positive predictive value of Pd ≥40 ms combined with Pmax ≥ 110 ms was 95.65%, 81.25% and 95.12%. Conclusion The Pd and Pmax in the patients with PAF are significantly higher than those in the patients without PAF, and Pd≥40 ms combined with Pmax≥ 110 ms can be used to predict the PAF more reliably and accurately.

Objective To explore the clinical significance of heart rate turbulence (HRT) in patients with chronic heart failure(CHF).Methods Thirty CHF patients(CHF group) and 28 non-organic heart disease persons (control group) were examined by 24 hours dynamic electrocardiogram (DCG).According to the NYHA grading of the cardiac function,CHF group were divided into low-degree heart failure (LdHF) sub-group (NYHA Ⅰ -Ⅱ,16 cases) and high-degree heart failure (HdHF) sub-group (NYHA Ⅲ-Ⅳ,14 cases).In CHF group,ischemic heart disease (IHD) patients were 18 cases and non-ischemic heart disease (NIHD) patients were 12 cases.Two indexes of HRT including turbulence onset (TO) and turbulence slope (TS) were measured and analyzed.Results The TO value in CHF group [(0.43 ±0.83)%] was significantly higher than that in control group [( - 1.49 ± 1.00)%] (P ＜0.05),and the TS value in CHF group[( 2.67 ± 0.66) ms/RRI] was significantly lower than that in control group [( 8.52 ± 2.09)ms/RRI] (P ＜0.05).The TO value in the HdHF sub-group [(0.79 ± 0.67)%] was significantly higher than that in LdHF sub-group[(0.12 ± 0.86)%] (P = 0.026),and the TS value in the HdHF sub-group [(2.88 ±0.79) ms/RRI] was significantly higher than that in LdHF sub-group [(2.40 ± 0.35) ms/RRI] (P= 0.045).The TO and TS values had no significant difference between the IHD and the NIHD patients (P＞0.05).In CHF group,53.3%(16/30) patients' TO and TS values were both abnormal (TO ≥ 0,TS ≤ 2.5 ms/RRI),and 40.0% (12/30) patients had only TO or TS value abnormal,93.3% (28/30) patients had abnormal HRT.Conclusion The phenomenon of HRT in the patients with CHF obviously decrease,and the HRT can be used to evaluate the severity of heart failure and predict the prognosis of the heart failure.

Objective To investigate the status and capacity of eye care services in Yunnan Province in 2007. Design Cross-sectional questionnaire survey. Participants 165 medical institutions in Yunnan Province. Methods Using a standardized questionnaire designed by Ministry of Health,the all hospitals of county or above and eye hospitals in Yunnan Province were investigated during October to December 2007. Main Outcome Measures Number of ophthalmologists and ophthalmic nurses,surgical volume per year,out-patient volume per year and number of ophthalmologists who can operate cataract independently. Results Totally 165 hospitals covered Yunnan Province participated in this study (response rate was 100%). In all these institutions,there were 735 ophthalmologists and 771 nurses. 392 ophthalmologists could perform cataract surgery independently. Within 16 prefectures of Yunnan,Zhaotong prefecture had the least resources of ophthalmology (7 ophthalmologists per million population) while Kunming had 32 ophthalmologists per million populations. In 2006,58346 eye surgeries were performed in all these institutions,including 23833 cases of cataract surgeries. 27 hospitals were not able to provide cataract surgical services. Out 165 institutions,only 29 hospitals (17.6%) had advanced ophthalmic equipments and 6 hospitals (3.6%) did not have any ophthalmic equipment. Conclusion There are big differences of eye care services among different level and different location of medical institutions in Yunnan Province of China. Inappropriate distribution of human resources and low productivity are main issues. Further resources allocation and optimized use of resources in eye care services are needed to meet the needs of patients.

Objective To observe the effect of maxillary sinus floor augmentation with transalveolar tech-nique and simultaneous implant.Methods 50 cases of patients with missing tooth in maxillary posterior region with insufficient vertical bone treated by author were selected.Maxillary sinus floor augmentation with transalveolar tech-nique and simultaneous implantation were given after local anesthesia.X -ray was given on the right day,2 weeks, 3 months and 9 months after operation.And the situation of osseointegration was observed.Results There were 2 cases of injuries of maxillary sinus mucoperiosteum in the 50 cases (4%),and no obvious complication was found for timely treatment.There were 5 cases of gingiva with obviously swollen around implant and BOP(+),and the symptoms were obliterated one week after paradental basic therapy and oral health guidance were given.All the situations of the osseointegration of implants were good,and no loosening or dropping case was found in follow up.One year after operation,the mean obsorbation of bone around the neck of implant was (0.9 ±0.3)mm.There was no obvious absorption of bone around implant,and obvious continuous image of maxillary sinus floor could be observed by imaging examination.The satisfaction of chew,pronounce,aesthetics,maintenance and comfort was all 100%,and 49 cases were satisfied with operation tolerance,and satisfaction rate was 98%.Conclusion Ther effect is desired to apply maxillary sinus floor augmentation with transalveolar technique and simultaneous implant under strict indication.And the satisfaction degree is high.

The β-cyclodextrin cross-linked polymer(β-CDCP) was used as adsorbent to pre-concentrate/separate the trace p-nitrophenol and then the determination was carried by UV-Vis spectrophotometry. Under alkaline condition,the adsorption/elution behavior of p-nitrophenol was studied. In 0. 02 mol/L NaOH solution and at room temperature for 30 min,the resin could separate and pre-concentrate the p-nitrophenol effectively. Methanol solution(1:1,V/V) was used as eluent and the β-CDCP could be used repeatedly. The linear range and detection limit was 0.5 -90.0 mg/L and 3. 10 μg/L,respectively. The proposed method has been used to determine the p-nitrophenol in synthesized sample with satisfactory results.

Objective] To analyse the course of treatment based on differentiation of signs of Hashimoto thyroiditis combined with many diseases, offering treating thought and medication experiences. [Method] Trace back and state the relative documents about the general conditions, diagnosis and therapy, symptoms-pointed treatment of 1 case of Hashimoto thyroiditis combined with many diseases, introducing Pro. Wumin's clinical experience in treating the patient. [Result] The patient was early or late diagnosed as fatness, hyperlipemia, hyperinsulinemia, sub-clinical Hypothyrea, thyroid nodule and type-2 diabetes, Pro. Wumin combined TCM with WM, the patient was control ed the diseases and kept stable. [Conclusion] Combination of TCM and WM treating Hashimoto thyroiditis accompanied with diseases above has good cure effect, the patient is satisfied with the improvement and result.

Yifeng (TE 17), Tinghui (GB 2), Zhongzhu (TE 3) and Xiaxi (GB 43) were selected as key acupoints plus hyperbaric oxygen to treat 50 cases of sudden deafness, and the total effective rate was 98%.

OBJECTIVE:To prepare Stemoninine orally disintegrating tablets,and to optimize its formulation and preparation technology. METHODS:Direct powder compression method was used to prepare Stemoninine orally disintegrating tablets. Using material angle of repose,disintegration time and taste evaluation as index,single factor test was used to screen several factors as bulking agent,disintegrating agent,glidant and flavoring agent;using disintegration time as index,L9(34) orthogonal test was used to optimize the formulation with ratio of MCC+mannitol,PVPP,silica powder and aspartame+stevia as factors. Validation test was also conducted. RESULTS:Optimized formulation was that MCC+mannitol(1∶1)was 50%,PVPP was 20%,silica powder was 2% and aspartame+stevia(10∶1)was 7%. 3 batches of prepared Stemoninine orally disintegrating tablets were smooth in sur-face and good in taste;their disintegrating time was(22.6±2.1)s,and weight variation,hardness,contents were within the speci-fied range (all RSD≤0.97%,n=3). CONCLUSIONS:The formulation and technology of Stemoninine orally disintegrating tab-lets are reasonable,and the quality indexes are all in line with the requirements of orally disintegrating tablets.

Objective:To invetigate the use of targeted anticancer drugs in our hospital during 2011-2013 to provide reference for the clinical rational drug use. Methods:The utilization of anti-tumor molecular targeted drugs in our hospital during 2011-2013 was retrospectively analyzed in respect of consumption sum, DDDs and DDC. Results:The proportion of consmption sum of anti-tumor mo-lecular targeted drugs in the total consumption sum was increased year by year, and that in 2012 and 2013 was over 60%. Protease ki-nase inhibitors accounted for 41. 29%-73. 41% in the consumption sum of anti-tumor molecular targeted drugs; monoclonal antibody accounted for 19. 40%-30. 88%; the other drugs accounted for 7. 19%-27. 83%. The consumption sum and the number of receiving medication patients of rituxan and cetuximab were not synchronized well, and the patients were born the higher cost. Conclusion:The use of anti-tumor molecular targeted drugs in our hospital is increased year by year, and the oral administration of anti-tumor molecular targeted drugs is with especially wide application.

AIM: To present the epidemiology, cause of injury, ocular status and final visual acuity after management of severe ocular trauma required hospitalization during 7 years in a representative urban Chinese population.METHODS: A retrospective analysis of the hospital admission files of ocular trauma patients admitted to the Daping hospital from January 2000 to December 2006 was carried out.RESULTS: A total of 268 patients were open-globe injury and the remaining 294 patients were closed-globe types. The most common causes of ocular injuries were metal (29.4%), explosive (14.6%) and stone (13.9%). And the visual outcomes of most of eye injury patients in this study were poor; half of injured eyes ended with visual acuity worse than 0.1.CONCLUSION: Therapeutic methods to ocular trauma make a great progress in recent years, but the visual outcomes are poor.