The purpose of this study was to investigate the morphologic changes of the bile canaliculi and its associated structures of the liver induced by common bile duct ligation(CBDL) in the rat. The canalicular surface and lateral surface of the dry-fractured hepatocytes was studied with scanning electron microscopy at 1~6 weeks post ligation. The first week after CBDL, the bile canaliculi were dilated. The microvilli were increased in number and the lumens contained granular materials After 2 weeks or more, the bile canaliculi were dilated to a variable degree, and with irregularity, measuring from 1.5 to 5 micrometer in diameter, and in the advanced stage, the canaliculi showed blunting and the disappearance of microvilli. Some canaliculi had sprouting side branches. At 4~6 weeks post-ligation, the lateral surface of the hepatocytes also showed some irregularity and a tortuous appearance, and numerous small sized microvillous projections were formed. The tubular structures of the proliferated SER distributed adjacent to the lateral surface of the hepatocytes, and the direct connection of a tubular structure and the cytoplasmic membrane was observed. These results suggest that the deformity and loss of microvilli of bile canaliculi reflect the disturbance of bile secretion from the hepatocytes. And prolonged obstruction of bile flow may result in bile excretion via the lateral surface of hepatocytes.
Rats ; Animals

No abstract available.
Pelvic Exenteration*

A clinical observation was made on 127 cases of benign prostatic hyperplasia, admitted to the Department of Urology, Chonnam National University Hospital during the period from January 1970 to August 1979. The results are summarized as follows: 1. There was an increasing tendency of annual distribution from 5 patients in 1970 to 32 patients in 1978. 2. Most of the patients were in the 7th and 8th decades of life (89%) with a mean age of 71.4 years old. 3. Seventy four patients (58.3%) suffered from acute urinary retention prior to admission. 4. Pyuria was revealed in 32 cases (25.2%), hematuria it 84 cases (66.1%), and azotemia in 4O cases (31.5%). 5. Associated conditions present were cardiovascular in 26 cases, respiratory in 21 cases, urologic in 15 cases, and miscellaneous in 6 cases. The most common associated conditions were hypertension in 20 cases and pulmonary tuberculosis in 15 cases. 6. Management was done with retropubic combined prostatectomy (RCP) in 12 cases, TURP in 33 cases. suprapubic transvesical prostatectomy (STP) in 23 cases, cystomy in 7 cases, and indwelling catheterization in 24 cases. 7. Prostatectomy was not performed in 31 cases because of patient refusal (14 cases) and associated conditions (17 cases) 8. The mean operating time was 87.5 minutes for RCP, 92.2 minutes for STP and 52.7 minutes for TURP. 9. The mean weight of the removed tissue was 48gm for open prostatectomy and 6.8gm for TURP. 10. The mean volume of transfused blood was 267ml for RCP, 591ml for STP and l45ml for TURP. 11. The mean period of postoperation was lO.6days for RCP, 11.7 days for STP and 4.6 days for TURP 12. The mean period of postoperative hospitalization was 13.4 days for RCP, 14.5 days for STP and 7.8 days for STP 7.8 days for TURP. 13. RCP postoperative complications were delayed healing with suprapubic urine leakage in 5 cases rebleeding in 2 cases, and acute epididymitis in 2 cases. STP postoperative complications were death due to hemorrhagic shock in 1 case, delayed healing with urine leakage in 2 cases, rebleeding in 3 cases, and prolonged gross hematuria more than 2 weeks in 2 cases. TURP postoperative complications were inability to void after removal of the urethral catheter in 1 case. prolonged gross hematuria more than two weeks in 1 case, and rebleeding in 3 cases.
Azotemia ; Catheters, Indwelling ; Disulfiram ; Epididymitis ; Hematuria ; Hospitalization ; Humans ; Hypertension ; Jeollanam-do ; Male ; Postoperative Complications ; Prostatectomy ; Prostatic Hyperplasia* ; Pyuria ; Shock, Hemorrhagic ; Transurethral Resection of Prostate ; Tuberculosis, Pulmonary ; Urinary Catheters ; Urinary Retention ; Urology

A clinical observation was made on 127 cases of benign prostatic hyperplasia, admitted to the Department of Urology, Chonnam National University Hospital during the period from January 1970 to August 1979. The results are summarized as follows: 1. There was an increasing tendency of annual distribution from 5 patients in 1970 to 32 patients in 1978. 2. Most of the patients were in the 7th and 8th decades of life (89%) with a mean age of 71.4 years old. 3. Seventy four patients (58.3%) suffered from acute urinary retention prior to admission. 4. Pyuria was revealed in 32 cases (25.2%), hematuria it 84 cases (66.1%), and azotemia in 4O cases (31.5%). 5. Associated conditions present were cardiovascular in 26 cases, respiratory in 21 cases, urologic in 15 cases, and miscellaneous in 6 cases. The most common associated conditions were hypertension in 20 cases and pulmonary tuberculosis in 15 cases. 6. Management was done with retropubic combined prostatectomy (RCP) in 12 cases, TURP in 33 cases. suprapubic transvesical prostatectomy (STP) in 23 cases, cystomy in 7 cases, and indwelling catheterization in 24 cases. 7. Prostatectomy was not performed in 31 cases because of patient refusal (14 cases) and associated conditions (17 cases) 8. The mean operating time was 87.5 minutes for RCP, 92.2 minutes for STP and 52.7 minutes for TURP. 9. The mean weight of the removed tissue was 48gm for open prostatectomy and 6.8gm for TURP. 10. The mean volume of transfused blood was 267ml for RCP, 591ml for STP and l45ml for TURP. 11. The mean period of postoperation was lO.6days for RCP, 11.7 days for STP and 4.6 days for TURP 12. The mean period of postoperative hospitalization was 13.4 days for RCP, 14.5 days for STP and 7.8 days for STP 7.8 days for TURP. 13. RCP postoperative complications were delayed healing with suprapubic urine leakage in 5 cases rebleeding in 2 cases, and acute epididymitis in 2 cases. STP postoperative complications were death due to hemorrhagic shock in 1 case, delayed healing with urine leakage in 2 cases, rebleeding in 3 cases, and prolonged gross hematuria more than 2 weeks in 2 cases. TURP postoperative complications were inability to void after removal of the urethral catheter in 1 case. prolonged gross hematuria more than two weeks in 1 case, and rebleeding in 3 cases.
Azotemia ; Catheters, Indwelling ; Disulfiram ; Epididymitis ; Hematuria ; Hospitalization ; Humans ; Hypertension ; Jeollanam-do ; Male ; Postoperative Complications ; Prostatectomy ; Prostatic Hyperplasia* ; Pyuria ; Shock, Hemorrhagic ; Transurethral Resection of Prostate ; Tuberculosis, Pulmonary ; Urinary Catheters ; Urinary Retention ; Urology

BACKGROUNDS: When measuring lung function and response to bronchodilator, MDI(metered-dose inhaler) is commonly used but unfamiliarity of its use and cold sensation by the puffed gas decrease reliability of the result. Spacer can reduce the cold freon effect and undesired oropharyngeal deposition caused by the rapid evaporation of the propellant and there are many studies which showed more effectiveness of spacer on the treatment of children with asthma but no study whether it is effective on the bronchodilator response test in the first medical examination of old age. Therefore, we tested whether the use of spacer can reduce the cold freon effect and improve the bronchodilator response in the first medical examination of old age. METHODS: Two hundred of elderly patients( 65years) who had never used MDI were measured the bronchodilator response. Subjects were randomised to either spacer-user or spacer-nonuser. Twenty minutes after 400 g fenoterol was administered, FEV1 (forced expiratory volume in one second) was measured. Bronchoconstriction was defined as a decrease in FEV1 by 10% or greater after bronchodilator inhalation. We further devided each group into normal or obstructive group, obstructive group was defined as FEV1<80% of predicted and FEV1/FVC<70%. RESULTS: In normal group, spacer-user(n=83) showed greater bronchodilator response than spacer-nonuser(n=66), 6.43% vs 3.81% respectively(p<0.05) and two case of bronchoconstriction occured only in spacer-nonuser. In obstructive group, there is no significant difference in bronchodilator response between spacer-user(n=18) and spacer-nonuser(n=33), 12.32% vs 11.16% respectively(p>0.05) but brochoconstriction(n=1) occured only in spacer-nonuser. CONCLUSION: Spacer improved bronchodilator response and prevented bronchoconstriction, in the first medical examination of old age.
Aged ; Asthma ; Bronchoconstriction ; Child ; Chlorofluorocarbons ; Fenoterol ; Humans ; Inhalation ; Lung ; Sensation

Lipoid pneumonia is chronic, interstitial, proliferative inflammation resulting from aspiration of lipoid material. Mineral oil is a hydrocarbon that physicians often use to treat chronic constipation in children and adults. Mineral oil may not elicit a normal protective cough reflex and may impair mucociliary transport. We experienced a case of exogenous lipoid pneumonia caused by aspiration of mineral oil given as a laxatives confirmed by fiberoptic bronchoscopy with bronchoalveolar lavage and bronchial biopsy in a 9-month-old boy with chronic cough and radiologic evidence of parenchymal lung disease.We reported this case with a brief review of related literatures.
Adult ; Biopsy ; Bronchoalveolar Lavage ; Bronchoscopy ; Child ; Constipation ; Cough ; Humans ; Infant ; Inflammation ; Laxatives* ; Lung ; Male ; Mineral Oil ; Mucociliary Clearance ; Pneumonia* ; Reflex

OBJECTIVES: This study was conducted to develop a smartphone application (app) as an educational learning instrument for coronary artery disease (CAD) patients and to assess the users' level of satisfaction. METHODS: This methodological research involves elicited learning content for CAD patients to develop a learning instrument using the smartphone app. The app was developed according to the steps of Assessment, Design, Development, Implementation, and Evaluation, which is a systematic instructional design model. The levels of satisfaction with the developed smartphone app among 30 outpatients with CAD were assessed via a questionnaire during their visits to a cardiology outpatient department. RESULTS: A smartphone app 'Strong Heart' was developed through reviewing the literature associated with education for CAD patients under professional supervision and searching for medical smartphone apps that are already available. The learning contents include six main sections containing essential learning issues in managing CAD and additional information to attract the user's attention, such as patient cases and quizzes. After modification with feedback from experts, the app was finally developed and evaluated by patients who reported that they were satisfied with the usefulness of the app. CONCLUSIONS: The developed smartphone app is available on both the iPhone App Store and the Android Play Store. Patients with CAD may utilize the app for supporting educational material without limitations of time and space.
Cardiology ; Coronary Artery Disease* ; Education ; Educational Technology ; Humans ; Learning ; Mobile Applications ; Organization and Administration ; Outpatients ; Patient Education as Topic ; Surveys and Questionnaires

No abstract available.
HLA-DR Antigens* ; Thyroid Gland* ; Thyroid Neoplasms*

BACKGROUND: Errors during measurement of blood pressure can cause over diagnosis or under diagnosis of hypertension, which can result in inappropriate management of hypertension and follow up consultation. The aim of this study was to investigate the factors affecting the accuracy of blood pressure measurement, which may serve as means to improve the accuracy of blood pressure measurements. METHODS: Among the 123 interns who work at Asan Medical Center, we selected 90 persons who agreed to join the study. Three interns were excluded because of their incomplete response to the questionnaire. Questionnaire for the survey concerning blood pressure measurement was created by selecting 5 case problems from a total of 34 cases provided within the blood pressure measurement CD ROM, which apply the Korotkoff sound technique. The factors that might affect the measurement were analyzed by multiple logistic regression. RESULTS: Fifteen (17.2%) interns failed to accurately measure blood pressure provided by the CD program. They showed a difference of greater than 10 mmHg between the actual and the measured systolic blood pressure. A discrepancy of greater than 5 mmHg was noted in the measurement of diastolic blood pressure. From the total sample of 87 interns, 15 (16.1%) interns showed digit preference (0 or 5), when measuring blood pressure. The discrepancy between the measured and the actual blood pressure was greater among those who had a digit preference (95% CI 1.055~17.770). CONCLUSION: Digit preference was the most important factor that affected the accuracy of blood pressure measurement taken by conventional sphygmomanometry. Effort to correct digit preference would improve the quality of blood pressure measurements.
Blood Pressure* ; Chungcheongnam-do ; Diagnosis ; Humans ; Hypertension ; Logistic Models ; Surveys and Questionnaires

OBJECTIVE: Closure of a low transverse cesarean incision with one layer and two layer, we compared operative time, hemostasis, blood loss and postoperative sonohysteroperitoneographic findings. Study design: At our hospital 103 women were randomized to closure of a low transverse cesarean incision with either one continuous layer of a locking No. 1 chromic suture or two continuous of No. 1 chromic suture with the first layer locked between Mar. 1, 1998 and Dec. 31, 1998. After three months later, sonhysteroperitoneography was taken and then we evaluated uterus indirectly. RESULTS: A one layer closure required less operative time, 16 versus 20.8 minutes (p<0.01), less hemoglobin change, 0.44 versus 1.3 (p<0.01) and less suture materials (p<0.01). But postoperative follow up sonohysteroperitoneography, a one layer closure shows slightly thinning of isthmic layer of myometrium, two layer closure shows more adhesional band and both are similar other findings. CONCLUSION: A one layer does not significantly affect the clinical course than traditional two layer closure. So we recommended a one layer closure when its use is anatomically feasible.
Animals ; Female ; Follow-Up Studies ; Hemostasis ; Humans ; Mice ; Myometrium ; Operative Time ; Sutures ; Uterus