Objective To study the effect of comprehensive treatment on common peroneal nerve injury. Methods 80 patients with common peroneal nerve injury were divided into treatment group (n=40) and control group (n=40). The treatment group accepted ultrashort wave, modulated medium frequency electrotherapy and electromyographic biofeedback therapy, while the control group accepted medication,acupuncture and excecise. All the patients were assessed with Fugl-Meyer assessment (FMA) in lower limbs before and after treatment.The effectiveness were recorded with MCRR. Results The scores of FMA of lower limb significantly improved after treatment and improved more in the treatment group than in the control group (P<0.05). The excellent and good rate was 80.00% in the treatment group, and 50.00% in the control group (P<0.01). Conclusion It is effective of comprehensive treatment on common peroneal nerve injury.