This study was to determine which of two routes of administration of 5-fluorouracil (5-FU) is more effective, by measuring the radioactvity in the body tissues of gastric cancer patients after the administration of 5-FU-l4C via the systemic intravenous and the regional intra-arterial routes. After the drug was administered intravenously in one group of patients, and intra-arterially in another; samples of portal venous blood, the liver, the lymph nodes, and the normal and the cancerous tissues of the stomach were obtained. The radioactivities of the samples were measured, and it was found that those of the regional lymph nodes, the liver, and the normal and the cancerous tissues of the stomach were much higher in the latter group. The regional intra-arterial routes is the more effective way to administer 5-FU in patients with stomach cancer.
Carbon Radioisotopes/diagnostic use ; Comparative Study ; Fluorouracil/administration & dosage ; Fluorouracil/metabolism* ; Human ; Injections, Intra-Arterial ; Injections, Intravenous ; Stomach Neoplasms/drug therapy* ; Stomach Neoplasms/metabolism

Food-dependent exercise-induced anaphylaxis(FDEIAn), first reported in 1979, is a rare condition characterized by acute cutaneous, gastrointestinal, cardiovascular, and respiratory symptoms occurring on exertion after certain meals. This article describes 3 patients who developed urticaria, dizziness, abdominal pain, and loss of consciousness if the ingestion of wheat flour-food was followed by exercise within 2 hours. But either exercise or wheat intake alone did not induce any symptoms. Skin prick test showed strong positive responses to wheat flour and bread in all patients. We could diagnose FDEIAn with specific food-exercise challenges.
Abdominal Pain ; Anaphylaxis* ; Bread ; Dizziness ; Eating ; Flour ; Humans ; Meals ; Skin ; Triticum ; Unconsciousness ; Urticaria

BACKGROUND: Laryngoscopy and tracheal intubation may cause hemodynamic changes, such as hypertension and tachycardia. Moreover, opioids are the most widely used drugs for hemodynamic stability. The purpose of this study was to determine the optimal dosage of alfentanil required to attenuate hemodynamic changes during anesthesia induction with propofol. METHODS: 120 ASA class 1-2 patients, scheduled for elective surgery, were divided randomly into 6 groups. Anesthesia was induced with propofol (2microgram/kg) followed by rocuronium (0.9microgram/kg). The control group received no alfentanil, and the study groups received 5, 10, 15, 20, or 25microgram/kg of alfentanil, respectively. Systolic blood pressure, mean arterial blood pressure, diastolic blood pressure and heart rate were measured preinduction (base), after propofol induction, immediately before & after intubation, and 1, 2, 3, 4, 5 minutes after intubation, respectively. RESULTS: After intubation, the increased heart rate and blood pressure were higher in the control and A5 groups, and this increased heart rate was not suppressed in the A10 group. The incidences of bradycardia and hypotension were also higher in the A20, and A25 groups. CONCLUSIONS: When anesthesia is induced with propofol, we suggest that the dosage of alfentanil for attenuating hemodynamic change during tracheal intubation be about 15microgram/kg.
Alfentanil* ; Analgesics, Opioid ; Anesthesia ; Arterial Pressure ; Blood Pressure ; Bradycardia ; Heart Rate ; Hemodynamics* ; Humans ; Hypertension ; Hypotension ; Incidence ; Intubation* ; Laryngoscopy ; Propofol* ; Tachycardia

PURPOSE: Numerous methods have been utilized to repair nasal septal perforation with varying degrees of success; however, no consensus has been reached on nasoseptal perforation repair. Here, the authors describe a surgical method based on human dermal allograft (Surederm(TM), Hans Biomed Corp. Korea) for the repair of nasal septal perforations. MATERIALS AND METHODS: Eleven patients with a nasal septal perforation were included in this study. The causes of these septal perforations included previous nasal surgery, trauma, foreign body (button battery), and idiopathy. There were several sites of perforation: 9 in the central area, 1 in the posterior-central area, and 1 in the anterior area. An interpositional graft incorporating Surederm(TM) was positioned between bilateral mucoperichondrial flaps using an intranasal approach. A silastic sheet was then left in the nasal septum bilaterally until complete healing had occurred through new nasal mucosa, which took a mean duration of 6 weeks. RESULTS: Outcomes in ten of the eleven patients were successful, with complete septal perforation closure. The remaining perforation, which was caused by a button battery, closed incompletely; however, its initial size of 2cm was reduced to 5mm. CONCLUSION: The described technique has a high success rate and can be performed under local anesthesia without external scarring. In the absence of donor site morbidity, this technique can also be utilized to repair posterior or multiple septal perforations without difficulty.
Adolescent ; Adult ; Aged ; Child ; Dermis/*transplantation ; Female ; Humans ; Male ; Middle Aged ; Nasal Septum/pathology/*surgery ; Nose Diseases/*surgery ; Skin Transplantation/methods ; Transplantation, Homologous ; Treatment Outcome

BACKGROUND AND OBJECTIVES: The development of saturation diving has enabled men to work underseas at great depths and for long periods of time. However, the utilization of HeO2 gas mixture has been a aubject of much study. This paper present a discussion effect of the helium gas on speech by usling gas machine which have been developed. MATERIALS AND METHODS: Twenty male volunteers without voice problems produced /a/ vowel sound before and after helium gas inhalation. The results were analyzed by using an aerophone, an acoustic analyzer, videostroboscopy, and a nasometer. RESULTS: The first formant, the second formant and the bandwidths of the second formant were significantly increased after helium gas inhalation. A meaningful change was noted in asalance. CONCLUSION: The helium gas has an effect on the resonant structure of oral and nasal cavity due to its physical characteristics.
Acoustics ; Diving ; Helium* ; Humans ; Inhalation ; Male ; Nasal Cavity ; Voice ; Volunteers

No abstract available.
Analgesia, Patient-Controlled* ; Female ; Humans ; Mammaplasty*

A 5 year-old, intact female Yorkshire terrier was referred for dysuria and dyschezia. The radiographic and ultrasound examination showed a round shaped mass caudal to the urinary bladder that contained anechoic fluid within the thin walls. During surgery, the cyst was noted to be attached to the outer wall of the vagina, not connected to the vaginal lumen. Cystic fluid was removed and the cystic wall was resected. Then the remaining cystic wall was omentalized to prevent a recurrence. Histological examination confirmed that the cyst was of Wolffian duct origin. In this case, a large Gartner duct cyst causing urological problems was diagnosed and removed by surgical resection.
Animals ; Constipation/etiology/veterinary ; Cysts/surgery/ultrasonography/*veterinary ; Dog Diseases/*pathology/surgery/ultrasonography ; Dogs ; Dysuria/etiology/veterinary ; Female ; Treatment Outcome ; Vaginal Diseases/complications/pathology/surgery/*veterinary ; Wolffian Ducts/*pathology/surgery

OBJECTIVES: The purpose of this study is to investigate the prevalence and the types of sinus abnormalities in a non-ENT population and draw any clinical correlation between the two phenomena. MATERIALS AND METHODS: We prospectively evaluated a total 120 patients who underwent brain magnetic resonance imaging (MRI) for suspected intracranial diseases from March to July 1997, in another department at Kang-buk Samsung Hospital. Patients who had been treated for nasal or sinus diseases and who had previous history of nasal or sinus operations were excluded. The sinus abnormalities found on MRI were classified into 6 types as follows; normal, mucosal thickening less than 3 mm and more than 3 mm, fluid collection, polyp or cyst, and others. RESULTS: Among 96 patients studied, 42 (43.7%) patients showed abnormality in one or more sinus group; 12 (20.7%) of the 58 asymptomatic patients and 30 (78.9%) of the 38 symptomatic patients. Sinus abnormalities were most commonly observed in the maxillary sinus. Most common abnormality was the mucosal thickening less than 3 mm. CONCLUSION: Incidental sinus abnormalities detected in a non-ENT population were relatively common. However, pathologic condition which demanded treatment among these abnormalities were rare. Therefore, it would be important to be careful not to overestimate these signs, and one should evaluate their clinical correlations through complete physical examinations before applying any treatment for these lesions.
Brain* ; Humans ; Magnetic Resonance Imaging* ; Maxillary Sinus ; Physical Examination ; Polyps ; Prevalence* ; Prospective Studies

BACKGROUND AND OBJECTIVES: Vocal polyps and nodules are representative chronic benign laryngeal diseases, and voice overuse, misuse, and abuse are felt by most authors to be the primary causative factors. Treatment options for vocal polyps and nodules in general include voice therapy by a speech-language pathologist and laryngeal microsurgery. The purpose of this study was to determine the changes in voice quality of a group of patients diagnosed with vocal polyp or vocal nodule before and after microlaryngeal surgery. MATERIALS AND METHOD: The following patients groups were studied prior to and 2 weeks after surgery: thirty-eight males, ages 27 to 62, and twenty five females, ages 23 to 47, with vocal polyp: three males, ages 29 to 38, and twenty eight females, ages 21 to 49, with vocal nodules. Voice recordings of the first sentence of a standardized paragraph "San Chaek" were performed for acoustic analyses. The recorded samples were analyzed on the Kay CSL model 4300B using Visi-Pitch II program. For the sentence, mean speaking fundamental frequency (F0), mean jitter and mean shimmer were analyzed. RESULTS: For the polyps, male patients showed decreased mean F0 (119.28 Hz), compared to the preoperative value (125.86 Hz) (p<0.05), and female patients showed increased mean F0 (197.52 Hz), compared to the preoperative value (190.07 Hz) (p=0.06). Mean jitter and shimmer improved in both males and females 2 weeks after surgery compared to their preoperative value (p<0.01). For the nodules, male patients showed decreased mean F0 (136.24 Hz) compared to the preoperative value (138.68 Hz), and female patients showed increased mean F0 (199.98 Hz) compared to the preoperative value (192.61 Hz) (p<0.05). Mean jitter and shimmer improved in both males and females 2 weeks after the surgery compared to their preoperative value. CONCLUSION: The acoustic output generally improved after laryngeal microsurgery as evidenced by the more appropriate mean F0 and reduced level of vocal perturbation. And, mean F0 showed different changes between males and female. Further research needs to be pursued on what this changes of mean F0 mean.
Acoustics ; Female ; Humans ; Laryngeal Diseases ; Male ; Microsurgery* ; Polyps* ; Voice Quality* ; Voice*