1.Bleeding from Dieulafoy's Vascular Malformation of the Proximal Ileum: A case report .
Hee Jung KIM ; Jun Keun JUNG ; Young Min SUH ; Kyung Sook KIM ; Hoguen KIM
Korean Journal of Pathology 1999;33(12):1207-1210
Dieulafoy's vascular malformation is a rare cause of massive gastrointestinal bleeding. Most often it occurs in stomach within 6 cm from the gastroesophageal junction. Only a few cases have been reported to occur in the small intestine and colon. Occasionally, Dieulafoy's lesion of small intestine is difficult to recognize because of rarity, a paucity of symptoms and negative findings on barium studies. Therefore, this lesion needs to be considered in a patient with massive lower gastrointestinal bleeding. We report a case of Dieulafoy's vascular malformation in ileum 2 m proximal to ileocecal value in a 41-year-old woman who visited emergency clinic because of hematemesis, dizziness and vomiting. Small intestine revealed a wide-caliber artery within the submucosa showing intimal thickening, medial muscular hypertrophy and thrombosis.
Adult
;
Arteries
;
Barium
;
Colon
;
Dizziness
;
Emergencies
;
Esophagogastric Junction
;
Female
;
Hematemesis
;
Hemorrhage*
;
Humans
;
Hypertrophy
;
Ileum*
;
Intestine, Small
;
Stomach
;
Thrombosis
;
Vascular Malformations*
;
Vomiting
2.MR Imaging Findings of Patients with Mesial Temporal Sclerosis.
Min Jung KIM ; Sun Yong KIM ; Jung Ho SUH
Journal of the Korean Radiological Society 2000;42(6):891-895
PURPOSE: To evaluate the MR imaging findings of patients with mesial temporal sclerosis. MATERIALS AND METHODS:We retrospectively reviewed the MR imaging findings of 116 patients diagnosed by MRI as suffering from mesial temporal sclerosis. In 18 of these, the condition was also histologically proven. RESULTS: Among the 116 patients, volume loss of the hippocampus was found in 95 (81.9%) and signal changes of the hippocampus in 53 (45.7%). Decreased signal intensity in the hippocampus on T1-weighted images was found in 13 (11.2%) and increased signal on T2-weighted images in 50 (43.1%). Signal abnormality in the hip-pocampus on both T1- and T2-weighted images was found in ten, and associated extrahippocampal abnormali-ties, as follows, in 20 (17.2%): atrophy of the fornix (n=10), atrophy of the mammillary body (n=8), atrophy of the amygdala (n=10), atrophy or increased T2 signal intensity of the anterior thalamic nuclei (n=2), atrophy of the cingulate gyrus (n=2), atrophy or increased signal intensity of the anterior temporal lobe (n=8), and cere-bral hemiatrophy (n=4). CONCLUSION: A high T2 signal and atrophy of the hippocampus are the most common and important MRI findings of mesial temporal sclorosis. Other abnormal findings, if any, which may be found in extrahippocampal structures such as the fornix, mammillary body and temporal lobe, should, however, also be carefully observed
Amygdala
;
Anterior Thalamic Nuclei
;
Atrophy
;
Epilepsy
;
Gyrus Cinguli
;
Hippocampus
;
Humans
;
Magnetic Resonance Imaging*
;
Mamillary Bodies
;
Retrospective Studies
;
Sclerosis*
;
Temporal Lobe
3.Three Cases of Hereditary Angioedema in One Family.
Kwang Suk SUH ; Jung Min KANG ; Kea Jeung KIM ; Hyung Jae KANG
Korean Journal of Dermatology 1995;33(3):564-569
Hereditary angioedema is a rare genetic disease transmitted with a autosomal dominant trait result of a quantitative or functional defect of Cl inhibitor. We report three cases of heriditary angioedema from the same famly respectively the 35-year-old sister, the younger bn)ther of 32, and the younger sister of 20 The older sister died due to her airway being obstructel by acute laryngeal edema, and her you igirbrother and sister experienced recurrent episodes oswelling on the hand and forearm. The ore we examined the two patients serum complement levils to confirm diagnosis. In both, the r;ults showed decreased levels of Cl inhibitor and C4 which are the evidence of hereditary a giedema. The younger sister has been administered danazol (600mg/day) to prevent angioedem or 8 weeks, and we have not yet found a recurrenc of he symptoms. However, well cont ol the dosage of danazol because amenorchea has developec.
Adult
;
Angioedema
;
Angioedemas, Hereditary*
;
Complement System Proteins
;
Danazol
;
Diagnosis
;
Forearm
;
Hand
;
Humans
;
Laryngeal Edema
;
Siblings
5.Immunohistochemical Analysis of nm23 Protein in Infiltrating Ductal Carcinoma of the Breast.
Min Hee JUNG ; Seung Cheol LEE ; Yoon Kyung SOHN ; In Soo SUH
Korean Journal of Pathology 1997;31(2):145-151
The nm23 gene was originally identified from murine melanoma cell lines of varying metastatic potential. A strong association has been observed between reduced expression of nm23 gene and acquisition of metastatic behavior in some tumor cells including breast cancer and melanoma, but not in others such as colon cancer, neuroblastoma, and cervical cancer. It was proposed that nm23 may function as a suppressor gene for tumor metastasis. It has recently been found that the sequence of nm23 and NDP-kinase(NDP-K) was identical. Mortality associated with human breast carcinoma is almost entirely due to subsequent metastasis, but the molecular basis of this metastasis is not understood. Elucidation of the genetic control of metastatic propensity of a tumor is important in determining prognosis and choice of therapy. The purpose of this study was to investigate the relationship of nm23 protein expression with axillary lymph node metastasis and other prognostic factors. Using an immunohistochemical technique and employing a polyclonal antibody to nm23 protein, we have determined nm23 expression in a series of 72 infiltrating ductal carcinomas of the breast. Immunostaining for the nm23 gene product have heterogenous cytoplasmic and nuclear staining in 61 patients(84.7%). Sections were scored according to relative abundance(1 = less than 25% of the cells, 2 = 26-75%, 3 = 76-100%). In 61 patients with positive immunostaining, the staining was scored as 1 in 41.6%, 2 in 18.0%, and 3 in 40.2%. The staining of tumor cells was greater than that in normal epithelial cells and stromal cells. No relationship was found between nm23 expression and lymph node metastasis, histologic grade, tumor size, estrogen receptors or progesterone receptors. Therefore, nm23 protein is increased in neoplastic tissues but no correlation with metastatic potential could be demonstrated. The biological mechanism of over-expression of nm23 in malignant cells and its role in tumor progression remain to be determined.
Breast Neoplasms
;
Breast*
;
Carcinoma, Ductal*
;
Cell Line
;
Colonic Neoplasms
;
Cytoplasm
;
Epithelial Cells
;
Genes, Suppressor
;
Humans
;
Lymph Nodes
;
Melanoma
;
Mortality
;
Neoplasm Metastasis
;
Neuroblastoma
;
Prognosis
;
Receptors, Estrogen
;
Receptors, Progesterone
;
Stromal Cells
;
Uterine Cervical Neoplasms
6.Immunohistochemical Analysis of nm23 Protein in Infiltrating Ductal Carcinoma of the Breast.
Min Hee JUNG ; Seung Cheol LEE ; Yoon Kyung SOHN ; In Soo SUH
Korean Journal of Pathology 1997;31(2):145-151
The nm23 gene was originally identified from murine melanoma cell lines of varying metastatic potential. A strong association has been observed between reduced expression of nm23 gene and acquisition of metastatic behavior in some tumor cells including breast cancer and melanoma, but not in others such as colon cancer, neuroblastoma, and cervical cancer. It was proposed that nm23 may function as a suppressor gene for tumor metastasis. It has recently been found that the sequence of nm23 and NDP-kinase(NDP-K) was identical. Mortality associated with human breast carcinoma is almost entirely due to subsequent metastasis, but the molecular basis of this metastasis is not understood. Elucidation of the genetic control of metastatic propensity of a tumor is important in determining prognosis and choice of therapy. The purpose of this study was to investigate the relationship of nm23 protein expression with axillary lymph node metastasis and other prognostic factors. Using an immunohistochemical technique and employing a polyclonal antibody to nm23 protein, we have determined nm23 expression in a series of 72 infiltrating ductal carcinomas of the breast. Immunostaining for the nm23 gene product have heterogenous cytoplasmic and nuclear staining in 61 patients(84.7%). Sections were scored according to relative abundance(1 = less than 25% of the cells, 2 = 26-75%, 3 = 76-100%). In 61 patients with positive immunostaining, the staining was scored as 1 in 41.6%, 2 in 18.0%, and 3 in 40.2%. The staining of tumor cells was greater than that in normal epithelial cells and stromal cells. No relationship was found between nm23 expression and lymph node metastasis, histologic grade, tumor size, estrogen receptors or progesterone receptors. Therefore, nm23 protein is increased in neoplastic tissues but no correlation with metastatic potential could be demonstrated. The biological mechanism of over-expression of nm23 in malignant cells and its role in tumor progression remain to be determined.
Breast Neoplasms
;
Breast*
;
Carcinoma, Ductal*
;
Cell Line
;
Colonic Neoplasms
;
Cytoplasm
;
Epithelial Cells
;
Genes, Suppressor
;
Humans
;
Lymph Nodes
;
Melanoma
;
Mortality
;
Neoplasm Metastasis
;
Neuroblastoma
;
Prognosis
;
Receptors, Estrogen
;
Receptors, Progesterone
;
Stromal Cells
;
Uterine Cervical Neoplasms
7.A Case of SRY Positive 46,XX Male.
Na Young CHUNG ; Yeong Heum YEON ; Min Ho JUNG ; Byung Kyu SUH ; Byung Churl LEE
Journal of Korean Society of Pediatric Endocrinology 2003;8(2):184-188
46,XX male is a rare abnormality of sex determination with an incidence of 1 in 20,000 male neonates. The clinical manifestations of 46,XX males are usually hypogonadism, gynecomastia, azoospermia, and hyalinations of seminiferous tubules, with altered hormonal levels at puberty. Less frequently, some sexual ambiguities are found, always with sterility owing to reduced testicular development. The origin of male phenotype in 46,XX male could be the results of at least three different mechanisms:translocations of Y sequence, including the SRY gene, to an X chromosome or to an autosome(about 90% of cases); a mutation in a yet unknown X-linked or autosomal gene in the testis-determinating pathway, and cryptic Y chromosome mosacism. We experienced a case of SRY-positive 46,XX male in a 21-year-old man with small testes. (J Korean Soc Pediatr Endocrinol 2003;8:184-188)
Adolescent
;
Azoospermia
;
Genes, sry
;
Gynecomastia
;
Humans
;
Hyalin
;
Hypogonadism
;
Incidence
;
Infant, Newborn
;
Infertility
;
Male*
;
Phenotype
;
Puberty
;
Seminiferous Tubules
;
Testis
;
X Chromosome
;
Y Chromosome
;
Young Adult
8.A Case of SRY Positive 46,XX Male.
Na Young CHUNG ; Yeong Heum YEON ; Min Ho JUNG ; Byung Kyu SUH ; Byung Churl LEE
Journal of Korean Society of Pediatric Endocrinology 2003;8(2):184-188
46,XX male is a rare abnormality of sex determination with an incidence of 1 in 20,000 male neonates. The clinical manifestations of 46,XX males are usually hypogonadism, gynecomastia, azoospermia, and hyalinations of seminiferous tubules, with altered hormonal levels at puberty. Less frequently, some sexual ambiguities are found, always with sterility owing to reduced testicular development. The origin of male phenotype in 46,XX male could be the results of at least three different mechanisms:translocations of Y sequence, including the SRY gene, to an X chromosome or to an autosome(about 90% of cases); a mutation in a yet unknown X-linked or autosomal gene in the testis-determinating pathway, and cryptic Y chromosome mosacism. We experienced a case of SRY-positive 46,XX male in a 21-year-old man with small testes. (J Korean Soc Pediatr Endocrinol 2003;8:184-188)
Adolescent
;
Azoospermia
;
Genes, sry
;
Gynecomastia
;
Humans
;
Hyalin
;
Hypogonadism
;
Incidence
;
Infant, Newborn
;
Infertility
;
Male*
;
Phenotype
;
Puberty
;
Seminiferous Tubules
;
Testis
;
X Chromosome
;
Y Chromosome
;
Young Adult
9.Motor Evoked Potential Study with Magnetic Stimulation In Ischemic Stroke Patients.
Seong Min KIM ; Sang Dug SUH ; Jun LEE ; Jung Sang HAH
Yeungnam University Journal of Medicine 1994;11(2):248-261
This study was undertaken to evaluate the clinical usefulness of magnetic motor evoked potential (MEP) in the diagnosis of stroke and predicting the motor improvement following stroke. The cortical, cervical and lumbar stimulations were performed in the case of 24 healthy controls and 24 to a target muscle between after transcranial stimulation and after cervical or lumbar stimulation. There was no case showing no response in controls. But in 11 out of 24 ischemic patients, we could not get cortical MEP. Mean CMCT of abductor pollicis brevis muscle was not significantly different in controls and stroke patients in whom MEPs were recorded. There were significant differences between mean CMCT of normal controls and that of stroke patients showing MEPs in AH Muscle. MEP Results from testing the stroke patients were correlated with site of lesion, degree of motor weakness and motor improvement after 1 to 2 months. These results suggest that magnetic MEP is easy and useful in electrophysiological test of central motor pathway and is useful indicator for representing the motor weakness and predicting the motor outcome in acute ischemic stroke patients.
Diagnosis
;
Evoked Potentials, Motor*
;
Humans
;
Stroke*
10.Lipid Profiles after Discontinuation of Growth Hormone Treatment in Adults with Childhood-onset Hypopituitarism.
In Suk YANG ; Min Ho JUNG ; Byung Kyu SUH ; Byung Churl LEE
Journal of Korean Society of Pediatric Endocrinology 2001;6(1):35-42
PURPOSE: The need for continuing Growth Hormone(GH) replacement after adolescence in patients with childhood-onset GH deficiency has been recognized. The purpose of this study was to evaluate the abnormalities of lipid profiles in young adults with childhood-onset hypopituitarism who discontinued GH therapy after the completion of height growth. METHODS: Nine male patients(mean age:22.4+/-3.3 years) with childhood-onset hypopituiatarism in whom GH treatment had been discontinued after final height was achieved were included. Their body mass index(BMI) and serum levels of total cholesterol, triglyceride(TG), high-density lipoprotein(HDL) cholesterol, and low-density lipoprotein(LDL) cholesterol were measured. The relationships of duration after GH discontinuation, age, and BMI to lipid profiles were anaylzed. RESULTS: BMI increased significantly from 21.8+/-1.9 kg/m2 before GH discontinuation to 23.0+/-3.0 kg/m2 after GH discontinuation(P<0.05). Serum levels of total cholesterol, TG, HDL cholesterol, and LDL cholesterol were 217.3+/-33.4, 237.8+/-128.2, 42.1+/-7.1, and 127.4+/-27.2 mg/dL, respectively, 3.1+/-2.0 years after GH discontinuation. Percentage of patients who had total cholesterol > or = 200 mg/dL, TG > or = 150 mg/ dL, LDL cholesterol > or = 140 mg/dL, and HDL cholesterol < or = 40 mg/dL were 77.8%, 88.9%, 44.4%, and 33.3%, respectively. All subjects had some abnormalities of lipid profiles. A significant positive correlation was found between duration after GH discontinuation and serum levels of total cholesterol and TG(r=0.84, P<0.01; r=0.83, P<0.01). A significant positive correlation was also found between age and serum levels of total cholesterol and TG(r=0.86, P<0.01; r=0.81, P<0.01). There were no correlations between BMI and serum lipid levels. CONCLUSION: Most of young adult patients with childhood-onset hypopituitarism had abnormal lipid profiles by 1-5 years after discontinuation of GH treatment. These data suggest that continuous GH treatment after completion of height growth is necessary.
Adolescent
;
Adult*
;
Cholesterol
;
Cholesterol, HDL
;
Cholesterol, LDL
;
Growth Hormone*
;
Humans
;
Hypopituitarism*
;
Male
;
Young Adult