No abstract available.
Eczema, Dyshidrotic* ; Guillain-Barre Syndrome* ; Immunization, Passive* ; Immunoglobulins*

BACKGROUND: A few studies have revealed increased levels of certain cytokines in patients with ischemic stroke. Cytokine changes have not been studied in patients with transient ischemic attack(TIA). The purpose of this study was to evaluate the temporal profile of the inflammatory response in patients with vertebrobasilar insufficiency (VBI) and to compare the inflammatory response between TIA and infarction through analyzing serum interleukin(IL)-6 and IL-10. METHODS: We serially measured the serum levels of IL-6 and IL-10 in 14 patients with VBI, 12 patients with vertebrobasilar territoy infarction, and 21 patients with lacunar infarction at the timing of admission, at 1 day after symptom onset, and at 5 day after symptom onset. Cytokines were measured by sandwich ELISA method. RESULTS: The IL-6 level obtained at day 1 was significantly elevated compared with the normal control group in patients with TIA (p<0.05). The IL-6 level at day 1 was the highest in patients with VBI. The level of IL-10 in patients with VBI was significantly higher than normal group at all time points(p<0.05). The IL-10 level at the timing of admission was the highest in patients with VBI. But the serum levels of IL-6 and IL-10 between VBI and vertebrobasilar territory and lacunar infarction groups did not show any differences. CONCLUSION: These findings show that pro- and anti-inflammatory cytokines in serum are elevated in patients with TIA. These results suggest that cytokine cascade occurs in TIA.
Cytokines ; Enzyme-Linked Immunosorbent Assay ; Humans ; Infarction ; Interleukin-10* ; Interleukin-6* ; Stroke ; Stroke, Lacunar ; Vertebrobasilar Insufficiency*

BACKGROUND: A few studies have revealed increased levels of certain cytokines in patients with ischemic stroke. Cytokine changes have not been studied in patients with transient ischemic attack(TIA). The purpose of this study was to evaluate the temporal profile of the inflammatory response in patients with vertebrobasilar insufficiency (VBI) and to compare the inflammatory response between TIA and infarction through analyzing serum interleukin(IL)-6 and IL-10. METHODS: We serially measured the serum levels of IL-6 and IL-10 in 14 patients with VBI, 12 patients with vertebrobasilar territoy infarction, and 21 patients with lacunar infarction at the timing of admission, at 1 day after symptom onset, and at 5 day after symptom onset. Cytokines were measured by sandwich ELISA method. RESULTS: The IL-6 level obtained at day 1 was significantly elevated compared with the normal control group in patients with TIA (p<0.05). The IL-6 level at day 1 was the highest in patients with VBI. The level of IL-10 in patients with VBI was significantly higher than normal group at all time points(p<0.05). The IL-10 level at the timing of admission was the highest in patients with VBI. But the serum levels of IL-6 and IL-10 between VBI and vertebrobasilar territory and lacunar infarction groups did not show any differences. CONCLUSION: These findings show that pro- and anti-inflammatory cytokines in serum are elevated in patients with TIA. These results suggest that cytokine cascade occurs in TIA.
Cytokines ; Enzyme-Linked Immunosorbent Assay ; Humans ; Infarction ; Interleukin-10* ; Interleukin-6* ; Stroke ; Stroke, Lacunar ; Vertebrobasilar Insufficiency*

Adult-onset metachromatic leukodystrophy (MLD) is very rare with a combination of cognitive and behavioral symptoms and peripheral polyneuropathy. A 47-year-old man was admitted due to memory impairment, gait disturbance, dysarthria and personality changes for a period of 3 years. The arylsulfatase A level in his leukocytes was decreased. A brain MRI showed bilateral symmetrical demyelination but nerve conduction velocities (NCV) were normal. We report a very rare case of adult-onset MLD with normal NCV.
Behavioral Symptoms ; Brain ; Cerebroside-Sulfatase ; Demyelinating Diseases ; Dysarthria ; Gait ; Humans ; Leukocytes ; Leukodystrophy, Metachromatic* ; Magnetic Resonance Imaging ; Memory ; Middle Aged ; Neural Conduction* ; Polyneuropathies

PURPOSE: To determine whether liver stiffness (LS) measured by magnetic resonance elastography (MRE) can predict the outcome of radiofrequency ablation (RFA) in hepatocellular carcinoma (HCC) patients. MATERIALS AND METHODS: A total of 107 patients with Child-Pugh class A liver function who were treated with RFA for single HCC and who had undergone a gradient-echo MRE within 6 months before RFA were included. We evaluated the relationship between the LS values and the ablation volume, local tumor progression (LTP), and intrahepatic distant recurrence (IDR). We also constructed receiver operating characteristic (ROC) curves to examine the role of LS in predicting liver function deterioration, which was defined as an increase of Child-Pugh score by one point or more at 1 year after RFA. RESULTS: There was no significant correlation between LS and ablation volume, and neither time to LTP nor IDR was associated with LS. Among the 66 patients who did not have recurrence 1 year after RFA, 5 patients (7.6%) developed liver function deterioration. A high LS value was significantly associated with development of liver function deterioration after RFA and the area under the ROC curve was 0.764 (95% CI 0.598-0.929, P = 0.003). CONCLUSION: LS measured by MRE could not predict ablation volume and tumor recurrence. However, high LS values were significantly associated with development of liver function deterioration.
Carcinoma, Hepatocellular* ; Catheter Ablation* ; Elasticity Imaging Techniques ; Humans ; Liver* ; Recurrence ; ROC Curve

Reversible posterior leukoencephalopathy is commonly associated with malignant hypertension, toxemia of pregnancy, or treatment with immunosuppressive drugs. A 17-year-old man who was diagnosed with traumatic rhabdomyolysis presented with seizure, visual disturbance, and severe pain in both thighs. Brain MRI revealed multiple areas of cortical and subcortical high signal intensities on T2 weighted images in the bilateral parieto-occipital lobes. He was treated with antihypertensive and anticonvulsant drugs and steroids. Forty days later, a follow-up MRI showed almost complete resolution of the brain lesions. The reversible posterior leukoencephalopathy may be associated with acute hypertension due to rhabdomyolysis-related acute renal failure. (J Korean Neurol Assoc 19(2):163~166, 2001)
Acute Kidney Injury ; Adolescent ; Anticonvulsants ; Brain ; Follow-Up Studies ; Humans ; Hypertension ; Hypertension, Malignant ; Leukoencephalopathies* ; Magnetic Resonance Imaging ; Pre-Eclampsia ; Rhabdomyolysis* ; Seizures ; Steroids ; Thigh

Reversible posterior leukoencephalopathy is commonly associated with malignant hypertension, toxemia of pregnancy, or treatment with immunosuppressive drugs. A 17-year-old man who was diagnosed with traumatic rhabdomyolysis presented with seizure, visual disturbance, and severe pain in both thighs. Brain MRI revealed multiple areas of cortical and subcortical high signal intensities on T2 weighted images in the bilateral parieto-occipital lobes. He was treated with antihypertensive and anticonvulsant drugs and steroids. Forty days later, a follow-up MRI showed almost complete resolution of the brain lesions. The reversible posterior leukoencephalopathy may be associated with acute hypertension due to rhabdomyolysis-related acute renal failure. (J Korean Neurol Assoc 19(2):163~166, 2001)
Acute Kidney Injury ; Adolescent ; Anticonvulsants ; Brain ; Follow-Up Studies ; Humans ; Hypertension ; Hypertension, Malignant ; Leukoencephalopathies* ; Magnetic Resonance Imaging ; Pre-Eclampsia ; Rhabdomyolysis* ; Seizures ; Steroids ; Thigh

Castleman disease is a rare lymphoproliferative lesion that is predominantly found in the mediastinum. Retroperitoneal and pararenal localizations are very rare. We describe a 36-year-old man with a hyaline vascular type of Castleman disease involving renal parenchyma and a paraaortic lymph node. Most reported renal Castleman disease was plasma cell type with systemic symptoms. Herein, we report the first Korean case of the hyaline vascular type of Castleman disease involving the renal parenchyma and the paraaortic lymph node simultaneously.
Adult ; Giant Lymph Node Hyperplasia ; Humans ; Hyalin ; Kidney ; Lymph Nodes ; Mediastinum ; Plasma Cells

We describe a patient with metronidazole-induced reversible encephalopathy characterized by dizziness, dysar- thria and ataxia. Brain T2 weighted magnetic resonance images(MRI) show increased signal intensities of the dentate nucleus of the cerebellum. Both neurological signs and abnormalities on MRI resolved dramatically with discontinuation of metronidazole.
Ataxia ; Brain ; Brain Diseases ; Cerebellar Nuclei ; Cerebellum ; Dizziness ; Humans ; Magnetic Resonance Spectroscopy ; Metronidazole

Seizures are a common presenting manifestation in patients in a nonketotic hyperglycemic(NKH) hyperosmolar state and the MR findings are typically hyperintense on T2 weighted (T2-W) and fluid attenuated inversion recovery (FLAIR) images. We recently experienced a case of the patient with partial seizure and nonketotic hyperglycemia who showed T2-W and FLAIR hypointensities with T1 weighted (T1-W) contrast enhancement.
Humans ; Hyperglycemia ; Seizures