1.Conservative surgery and radiation therapy in the treatment of stage I and II breast cancer.
Journal of the Korean Cancer Association 1992;24(1):125-129
No abstract available.
Breast Neoplasms*
;
Breast*
2.Inhibition Effect of Angiostatin and Endostatin on Human Angiogenesis.
Journal of the Korean Surgical Society 2001;60(1):1-7
PURPOSE: Angiogenesis is a critical determinant of tumor growth and the development of metastasis. Angiostatin and endostatin have been used in a variety of in vitro and in vivo animal models as effective inhibitors of angiogenesis. However, human angiostatin and endostatin have not been tested against an intact human tissue target in vitro to determine its ability to achieve an antiangiogenic response. We performed our study to determine if human angiostatin and endostatin would inhibit the development of an angiogenic response (initiation) and to determine the subsequent growth (angiogenic index) of human vessels in a dose-dependent manner with a human placental vein angiogenesis model (HPVAM). METHODS: We used full thickness human placental vein discs cultured in three-dimensional fibrin-thrombin clots with an overlay of liquid media. Human angiostatin and endostatin were evaluated in concentrations ranging from 10-9 M to 10-4 M. A positive control containing 20% fetal bovine serum and a negative control using heparin and hydrocortisone 21-phosphate were also tested. RESULTS: Human angiostatin did not inhibit the initiation of an angiogenic response and the subsequent development of the angiogenic response (angiogenic index) at any concentration. Human endostatin significantly inhibited the initiation rate of an angiogenic response at a concentration of 10-4 M (p<0.001) and the subsequent development of an angiogenic response (angiogenic index) from a concentrations of 10-5 M to 10-4 M (p<0.001, p<0.001, respectively). CONCLUSION: We conclude that a very high concentration of human endostatin can inhibit the angiogenic response in human vascular tissue and that human angiostatin will not inhibit angiogenesis of normal human blood vessels in vitroThese results suggest that human endostatin has a more powerful antiangiogenic effect than human angiostatin, but we need further investigations of human angiostatin against an intact human tissue target.
Angiostatins*
;
Blood Vessels
;
Endostatins*
;
Heparin
;
Humans*
;
Hydrocortisone
;
Models, Animal
;
Neoplasm Metastasis
;
Veins
3.Clinical analysis of he benign gastric tumors.
Jun Min KANG ; Min Hyuk LEE ; Ik Su KIM
Journal of the Korean Surgical Society 1992;43(1):15-23
No abstract available.
4.A clinical observation of emphysema of the gallbladder.
In Dong HWANG ; Min Hyuk LEE ; Kyung Bal HUR
Journal of the Korean Surgical Society 1991;40(4):459-467
No abstract available.
Emphysema*
;
Gallbladder*
5.A study on the length of the human umbilical cord.
Min Hee KIM ; Young Hyuk LEE ; Kyo Sun KIM
Journal of the Korean Pediatric Society 1991;34(12):1641-1646
No abstract available.
Apgar Score
;
Humans*
;
Umbilical Cord*
6.A clinical study of gallstone disease in elderly patients.
Young Joon KIM ; Min Hyuk LEE ; Kyung Bal HUR
Journal of the Korean Surgical Society 1992;43(1):67-77
No abstract available.
Aged*
;
Gallstones*
;
Humans
7.An experimental study on enhanced antitumor effect of cyclophosphamide by methylxanthines human gastric cancer cells(NUGC-4).
Jae Jun KIM ; Min Hyuk LEE ; Kyung Bal HUR
Journal of the Korean Cancer Association 1992;24(4):469-479
No abstract available.
Cyclophosphamide*
;
Humans*
;
Stomach Neoplasms*
9.The benefit of incidental appendectomy associated with cholecystectomy.
Hyeun Bag CHO ; Min Hyuk LEE ; Hee YOO
Journal of the Korean Surgical Society 1993;45(6):977-983
No abstract available.
Appendectomy*
;
Cholecystectomy*
10.Morphologic Study on the Mesothelial Hyperplasia in the Rat.
Chan CHOI ; Min Cheol LEE ; Kyu Hyuk CHO
Korean Journal of Pathology 1985;19(2):160-167
Reactive mesothelial cells are frequently found in the smear, of body fludid dffusion when associated with liver cirrhosis, pulmonary tuberculosis, congestive heart failure or pulmonary infarction. But it is not easy to differentiate these reactive mesothelial cells from macrophages or various types of malignant cells. In order to investigate the morphology of hyperplastic mesothelial cells, in comparison with the various types of malignant cells in the effusion, this experiment was designed. The tissue reaction was evoked by intraperitoneal injection of 2.5 ml of 2% Talcum suspension. The results obtained were as follows: 1) On light microscopic observation of the tissure, until 5 days, cytoplasm and nucleus of mesothelial cells became larger and nucleoi became prominent. After then, cytoplasm and nucleus became smaller and at 28 days after injection of Talcum suspension, cellular features became similar to those of normal ones. 2) On cytologic observation of touch print specimens, hyperplastic mesothelial cells became round to oval, and their cytoplasm became conspicuous. Nuclei were vesicular, and nucleoi were prominent. N/C ratio was decreased than normal. 3) On electron microscopic observation, hyperplastic mesothelial cells did not have microvilli, but had a few cytoplasmic globular projections, loosely approximated cellular junctions, larger and more abundant intracytoplaomic vesicles when compared with normal one. Chromatin clumping, irregular thickening of nuclear membrane and prominent nucleoi were also noted.