No Abstract Available.
Acne Vulgaris* ; Adolescent* ; Humans

No abstract available.
Cisterna Magna*

PURPOSE: The purpose of this study was to identify awareness and knowledge about hepatitis B virus (HBV) infection among North Korean immigrants who had resided in South Korea. METHODS: This was a cross-sectional, community based study. Data were collected from a convenience sample of 198 North Korean immigrants aged 18 years old through 65 years old among those who had attended community centers, local churches, and gathering places in four cities. The questionnaire included 15 items about participants' knowledge on HBV infection and its consequences, mode of transmission, and preventive measures. RESULTS: The mean score of HBV knowledge was 6.3±3.8 (range 0~15). The items that over 60% of the respondents checked correct answer regarding knowledge about HBV were 'There is blood screening for hepatitis B infection', 'Hepatitis B can be transmitted through sharing needles with infected person'. Multivariate analysis showed that received education for the prevention of HBV infection and disease morbidity were significantly associated with the knowledge of HBV infection. Overall, approximately 11% of total variability in the knowledge of HBV infection could be explained by the 2 variables in this model (R²=.109, p<.001). CONCLUSION: The results showed that North Korean immigrants need more education on HBV infection and prevention to improve their knowledge about HBV.
Education ; Emigrants and Immigrants* ; Hepatitis B virus ; Hepatitis B* ; Hepatitis* ; Humans ; Korea ; Mass Screening ; Multivariate Analysis ; Needles ; Surveys and Questionnaires

Schizophrenia is a devastating mental illness that can lead to deterioration in the social and occupational functioning of affected individuals with a major cost to society. A wide range of studies suggest a genetic component to the inheritance of schizophrenia. The molecular genetic studies on schizophrenia have been actively performed since late 1980s. In linkage studies, no loci were replicated across studies and there were no loci surpassing genome-wide significance. Candidate gene association studies showed generally inconsistent results and there were no enrichment of smaller P-values. In the GWAS era, the community has coalesced into large international consortia. The largest schizophrenia GWAS to date is 50,000 samples and efforts are ongoing to accumulate 50,000 cases and 50,000 controls as part of 'PGC2' collaboration. With the limitation of GWAS results, several alternatives are being explored. In genotyping, the concepts of allelic spectrum including from common polygenic to rare penetrant variation are emerging. Phenotypes include all phenomena beyond DNA. The developments in transcriptomic & proteomic approach and intensive research on endophenotype will bring crucial insights into the nature of schizophrenia in the future. But there still remains our task about research on many factors including environment that influence gene expression (epigenetics), age, and gender.
Cooperative Behavior ; DNA ; Endophenotypes ; Epigenomics ; Gene Expression ; Genetic Association Studies ; Molecular Biology ; Phenotype ; Schizophrenia ; Wills

No abstract available.
Carcinoma, Basal Cell* ; Nevus*

Secondary mania is closely linked to neurocircuitry defects. Frontal-subcortical circuits, in particular, play a major role in the affective, motor and cognitive symptoms of secondary mania. In this paper, we present the three main frontal-subcortical circuits : the dorsolateral prefrontal circuit, which mediates executive functions (i.e., the organization of information to facilitate a response) ; the anterior cingulate circuit, which is involved in motivated behavior ; the orbitofrontal circuit, which has medial (i.e., integration of visceral-amygdalar functions with the internal state of the organism) and lateral divisions (i.e., integration of limbic and emotional information into contextually appropriate behavioral responses). Impaired executive functions, apathy, disinhibition and impulsivity are hallmarks of frontal-subcortical circuit dysfunction. The various neuropsychiatric manifestations of secondary mania may result from disturbances that have a direct or indirect impact on the integrity or functioning of these loops.
Apathy ; Bipolar Disorder* ; Executive Function ; Impulsive Behavior ; Neurobehavioral Manifestations

PURPOSE: Myocardial SPECT is an effective test for detecting coronary artery disease in the general population. But the diagnostic accuracy between sexes is not defined. The purpose of this study is to compare the diagnostic accuracy between males and females. MATERIALS AND METHODS: One hundred and seventy seven male and 98 female patients who underwent myocardial SPECT within 1 month of coronary angiography were studied. Myocardial SPECTs were considered abnormal if fixed or reversible perfusion defects were detected. Stenosis severity of > or = 50% luminal diameter reduction of any artery defined coronary artery disease (CAD). RESULTS: Overall sensitivity for detection of CAD was 98% in men and 97% in women (p=not significant). However, specificities, accuracies, and positive predictive values (PPV) in men and women were 49% vs 31% (p<0.05), 81% vs 57% (p<0.01), 78% vs 48% (P<0.01), respectively Diagnostic accuracies for detection of right coronary artery disease were not different in both sexes, however, accuracies for detection of left anterior descending artery disease and left circumflex artery disease were significantly lower in female (p<0.05). CONCLUSION: A significant difference of diagnostic accuracy between sexes, especially in LAD and LCx disease, was noted. Artifacts from breast attenuation might be a cause for the lower diagnostic accuracy in female.
Arteries ; Artifacts ; Breast ; Constriction, Pathologic ; Coronary Angiography ; Coronary Artery Disease* ; Coronary Vessels* ; Female ; Humans ; Male ; Perfusion* ; Phenobarbital ; Tomography, Emission-Computed, Single-Photon*

Purpose: The purpose of this study was to evaluate the effect of preoperative warming to prevent hypothermia in surgery for patients undergoing total hip replacement arthroplasty under spinal anesthesia. Methods: A randomized experimental study was conducted. Data were collected at an S University hospital in Gyeonggido from December 3, 2019 to March 31, 2020. A random allocation program was used to randomize participants into intervention and control groups. A total of 90 participants were assigned to the study: 30 people were randomized to a pre-warming group using Bair Hugger forced-air warming blankets(Model 505) 30 minutes before surgery, 30 to a pre-warming group 15 minutes before surgery, or 30 to a control group. The findings from 88 participants were analyzed. For data analysis, x2 test and ANOVA were used utilizing the SPSS 21.0 program. Results: The pre-warming group 30 minutes before surgery had significantly higher body temperature than the control group, from 30 minutes after inducing anesthesia to the end of anesthesia. Body temperature over anesthesia time showed significant differences among the three groups, but there were no statistically significant differences in interactions between time and groups. Conclusion Warming patients' body for 30 minutes before surgery was effective in maintaining normal body temperature while preventing intraoperative hypothermia.

A 47-year-old man with end-stage renal disease due to diabetic nephropathy underwent a peritoneal scintigraphy to evaluate the cause of recently developed scrotal swelling. Two liters of dialysate mixed with 111 MBq of Tc-99m sulfur colloid were administered into the peritoneal cavity via the dialysis catheter. Various anterior images of the abdomen and pelvis were obtained at 15 min, 2 hr and 4 hr after the tracer instillation. At 15 min, anterior images of the abdomen and pelvis demonstrated linear tracts of activity through both inguinal canals, which were more prominent in the right side (A). Images at 2 hr revealed a passage of the radioactive fluid into the right hemiscrotum. At the same time, there was a considerable accumulation of activity in the right inguinal canal (B). In the delayed image, there was a progressive accumulation of activity in the inguinal canals and a prominent passage of the tracer into the scrotum (C). Both abdominal and inguinal hernias are commonly associated with continuous ambulatory peritoneal dialysis (CAPD). Overall incidence of CAPD-induced hernia ranges from 2.7% to 25%.1) Inguinal hernias were frequently manifested as scrotal swelling. Leakages of dialysate fluid into the scrotum has been noted in CAPD patients with scrotal swelling, with or without clinical findings of inguinal hernia.1,2) In the present case, the right side had leakage from a clinical inguinal hernia and the left side, leakage from a subclinial inguinal hernia. A subclinical inguinal hernia was easily demonstrable with peritoneal scintigraphy. Peritoneal scintigraphy is extremely helpful in the evaluation of scrotal swelling in a patient on CAPD.
Abdomen ; Catheters ; Diabetic Nephropathies ; Dialysis ; Hernia ; Hernia, Inguinal* ; Humans ; Incidence ; Inguinal Canal ; Kidney Failure, Chronic ; Middle Aged ; Pelvis ; Peritoneal Cavity ; Peritoneal Dialysis, Continuous Ambulatory* ; Radionuclide Imaging* ; Scrotum ; Technetium Tc 99m Sulfur Colloid

PURPOSE: There was little evidence that Tc-99m labeled ciprofloxacin (Infecton) located inside of bacteria. Antimicrobial activity of Infecton could be an indirect evidence of its location. We compared in vitro antimicrobial activities of Infecton and ciprofloxacin. MATERIALS AND METHODS: Minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC) of Infecton and ciprofloxacin against three standard strains of bacteria, Staphylococcus aureus ATCC 29213, Escherichia coli ATCC 25922 and Pseudomonas aeruginosa ATCC 27853 were measured using modified broth macrodilution techniques and pour plate methods, respectively. Data were expressed as mean+/-SE (range). RESULTS: MICs of Infecton and ciprofloxacin were 1.12+/-0.20 (0.8~1.6) microgram/ml and 0.36+/-0.04 (0.2~0.4) microgram/ml for S. aureus, 0.03+/-0.005 (0.025~0.05) microgram/ml and 0.011+/-0.001 (0.006~0.012) microgram/ml for E. coli, and 0.96+/-0.16 (0.8~1.6) microgram/ml and 0.56+/-0.098 (0.4~0.8) microgram/ml for P. aeruginosa, respectively. MBCs of Infecton and ciprofloxacin were 2.56+/-0.39 (1.6~3.2) microgram/ml and 0.88+/-0.2 (0.4~1.6) microgram/ml for S. aureus, 0.04+/-0.06 (0.025~0.05) microgram/ml and 0.02+/-0.01 (0.025~0.05) microgram/ml for E. coli, and 2.24+/-0.39 (1.6~3.2) microgram/ml and 1.44+/-0.16 (0.8~1.6) microgram/ml for P. aeruginosa, respectively. CONCLUSION: Although both MICs and MBCs of Infecton were higher than those of ciprofloxacin, all three standard bacterial strains were sensitive to Infecton. It could be an indirect evidence that Tc-99m Infecton be a specific imaging agent for bacterial infection.
Bacteria ; Bacterial Infections ; Ciprofloxacin* ; Escherichia coli ; Microbial Sensitivity Tests ; Pseudomonas aeruginosa ; Staphylococcus aureus