Digestive System Surgical Procedures ; methods ; Gastroplasty ; methods ; Humans ; Minimally Invasive Surgical Procedures

Humans ; Natural Orifice Endoscopic Surgery ; methods ; trends

Laparoscopic surgery for gastrointestinal diseases had a remarkable progress in the past 20 years. Laparoscopic surgery for colon cancer is adopted worldwide by increasingly surgeons based on the evidence from randomized controlled studies. Minimally invasive surgery is also adopted as alternative procedure for early gastric cancer. The standardization and spreading of the minimally invasive technique for gastrointestinal surgery is also being implemented efficiently in China. However, how to innovate the new technique and improve the new instrumentation for minimally invasive surgery is still a problem which we have to confront in the current situation. But we believe that with the great efforts of gastrointestinal surgeons, the widespread adoption of minimally invasive gastrointestinal surgery would surely take place in the near future.
China ; Female ; Gastrointestinal Tract ; surgery ; Humans ; Laparoscopy ; methods ; Male ; Minimally Invasive Surgical Procedures ; methods

Humans ; Laparoscopy ; Rectal Neoplasms ; surgery

Biomedical Research ; Humans ; MicroRNAs ; Neoplasm Invasiveness ; genetics ; Neoplasm Metastasis ; genetics

Objective To analyze 85 cases of small bowel stromal tumor with follow-up results,and compare the clinical factors on the prognosis of disease. Methods Getting started from clinical records,a specific database was designed and clinical data concerning patient demographics,clinical findings,lab results,radiology reports,endoscopy reports,perioperative parameters,pathology reports and follow-up notes were input into the database. The influences of clinical factors on prognosis were compared by inquiring about the database. Results It was revealed through follow up that the maximal tumor diameter(relative risk,1.7) and tumor surface ulceration(relative risk,6.0) were two independent prognostic factors closely related to the survival(P

Objective: To investigate the optic magnetic resonance imaging (MRI) findings in patients with neuromyelitis optica (NMO). Methods: Patients with suspected NMO underwent brain, spinal cord and the optic MRI scanning and imaging analysis; 41 patients who met the latest diagnosis criteria of NMO were enrolled in the present study and were the followed up. The MRI characteristics of the optic nerves at different stages were analyzed, and 32 healthy volunteers served as control. The results of visual evoked potential (VEP) were analyzed retrospectively to investigate whether there was difference between the positive rate of VEP and MRI findings. Results: MRI imaging showed that the shape of bilateral optic nerves was straight in healthy volunteers, and just a moiety of the optic showed slightly higher signal. In NMO patients, signals of the optic at unilateral or bilateral side were obviously intensified and appeared like railway lines, which was different from healthy volunteers. In acute phase, 22 (53.7%) patients were accompanied by optic swelling and/or distortion, 31 (76.5%) had enhanced T1 WI, and 17 (41.5%) had high-point signal in the optic nerve. In the remission stage, 15 (36.6%) had their optic nerves atrophied, thinned or even distorted on unilateral and/or bilateral side. At the end of the study, 35 (80.5%) showed high-point signal in the optic nerve. The overall sensitivity of MRI was 94.6%, but in acute phase the sensitivity was just 43.6%, indicating the sensitivity of MRI was time-dependent and was not as sensitive as VEP. Conclusion: MRI can clearly demonstrate the changes at different stages of optic nerve atherosclerosis in NMO patients. MRI may be the first choice for diagnosis of NMO.

Animals ; Apoptosis ; drug effects ; Capillaries ; pathology ; Fibrosis ; Fingolimod Hydrochloride ; Kidney Diseases ; metabolism ; pathology ; Kidney Tubules ; blood supply ; Male ; Propylene Glycols ; pharmacology ; therapeutic use ; Rats ; Rats, Sprague-Dawley ; Sphingosine ; analogs & derivatives ; pharmacology ; therapeutic use ; Vascular Diseases ; prevention & control

Colectomy ; methods ; Colorectal Neoplasms ; mortality ; pathology ; surgery ; Humans ; Laparoscopy ; Treatment Outcome

Objective: To observe the effect of scraping therapy (ST) on the immune balance of serum helper T (Th) 1/Th2 cells in autologous nucleus pulposus transplantation non-compressive lumbar disc herniation (LDH) model rats, and explore the immune mechanism of ST in reducing LDH pain. Methods: Seventy-two male Sprague-Dawley (SD) rats were randomly divided into a model group, a sham operation group and a ST group, with 24 rats in each group. Autologous nucleus pulposus transplantation non-compressive LDH models were established in the model group and ST group, while the rats in the sham operation group underwent sham operation without model establishment. On the fifth day after the model was successfully prepared, rats in the ST group received ST, once every other day, 3 times as a course for a total of 3 courses. Six rats in each group were randomly selected to observe their pain thresholds, and peripheral blood of the rats was collected before the first scraping treatment and at the end of the first, second, and third courses of treatment. The serum was isolated and enzyme-linked immunosorbent assay (ELISA) was applied for the detection of rat serum interferon (IFN)-γ, interleukin (IL)-4 and IL-10. Results: Compared with the model group, the pain threshold in LDH rats in the ST group increased (P<0.05), the serum IFN-γ level was significantly reduced (P<0.05), but the levels of IL-4 and IL-10 did not change significantly (both P>0.05). At the end of the second and third courses of treatment, the IFN-γ/IL-4 ratio was negatively correlated with the pain threshold in the rats, and the IFN-γ/IL-4 ratio was significantly reduced in the ST group (P<0.01). Conclusion: ST can help suppress the Th1 immunity in LDH rats triggered by the autologous nucleus pulposus, restore the immune balance of Th1/Th2, and reduce the pain of LDH.