1.Clinical Characteristics of Postmenopausal Patients with Cervical Intraepithelial Neoplasia Grade Ⅱ or Above
Chinese Journal of Minimally Invasive Surgery 2017;17(2):155-158
Objective To investigate the clinical characteristics of postmenopausal patients with cervical intraepithelial neoplasia ( CIN) gradeⅡ/Ⅲand cervical cancer . Methods A retrospective analysis was made on the clinical characteristics of 57 cases of postmenopausal patients who were diagnosed as CIN grade Ⅱor above from January 2014 to September 2015.Their age ranged from 49 to 77 (58.2 ±5.6) years old, and the time of menopause ranged from 1 to 36 (9.4 ±6.9) years. Results ①In postmenopausal women with CIN Ⅱ/Ⅲ and cervical cancer, only about 1/5 (11/57, 19.3%) had clinical complaints, and nearly 2/3 (36/57, 63.2%) had smooth cervical appearance .②There were 36 cases of high-risk human papillomavirus ( HPV) (36/39, 92.3%), 20 cases of single HPV16 infection (20/36, 55.6%), 7 cases of HPV16 type and other high-risk HPV infection (7/36, 19.4%), and 9 cases of other types of high-risk HPV infection (9/36, 25.0%).③The positive rate of high-risk HPV was 92.3%(36/39) and the HPV16 positive rate was 69.2% (27/39).TCT examination showed a positive rate of high grade squamous intraepithelial lesion (HSIL) of only 29.6% (16/54), with significant difference (χ2 =6.686 and 14.286, P =0.010 and 0.000, respectively). Conclusions Postmenopausal women with cervical lesions usually have no obvious clinical symptoms . Gynecological examination alone is difficult to judge whether the cervical lesions exist .Strict cervical lesions screening is particularly important .
2.Comparison of Electrogastrogram and Gastroscopy in 136 Children with Gastric Disease
Journal of Applied Clinical Pediatrics 2004;0(07):-
Objective To study and evaluate the consistency and diagnostic value of electrogastrogram(EGG) and gastroscopy in children′s gastrosis diagnosis.Methods A total of 136 children were checked with gastroscopy and EGG during the same period,then compared the diagnostic accordance rate with 2 ways,and analyzed the characteristics of EGG.Results EGG showed certain characteristics in different gastrosis.Diagnosis of EGG in the group of functional illness was consistence with gastroscopy at 95.8%;others were less than 40%.Conclusion EGG can be used as a method of special value to diagnose children′s functional gastrosis and a screening means in general gastrosis.
3.Asynchronous primary cancers in breast and extraperitoneum.
Hao-hao ZHU ; Min-feng ZHANG ; Jia-rong MENG
Chinese Journal of Pathology 2006;35(11):700-700
Antigens, CD
;
metabolism
;
Antigens, Differentiation, Myelomonocytic
;
metabolism
;
Breast Neoplasms
;
metabolism
;
pathology
;
surgery
;
Carcinoma, Lobular
;
metabolism
;
pathology
;
surgery
;
Female
;
Histiocytoma, Malignant Fibrous
;
metabolism
;
pathology
;
surgery
;
Humans
;
Immunohistochemistry
;
Middle Aged
;
Receptors, Progesterone
;
metabolism
;
Retroperitoneal Neoplasms
;
metabolism
;
pathology
;
surgery
4.Clinical evaluation of different diopter myopia after epipolis laser in situ keratomileusis
Ke, WU ; Zhi-min, LI ; Hao, GU
Chinese Journal of Experimental Ophthalmology 2011;29(8):743-746
Background Epipolis laser in situ keratomihusis(Epi-LASIK) is an potential surgery for myopia because it synthesize advantages of LASEK and LASIK. But its clinical effectiveness and safeness is remarkable.Objective This study was to evaluate the clinical curative effects and safeness of Epi-LASIK for myopia in different diopter of population. Methods Retrospective study was designed for 208 eyes of 104 patients who underwent EpiLASIK for the correction of myopia. The patients were divided into two groups according to preoperative diopter:lower myopia group( ≤ -6.00 D, 111 eyes) and high myopia group ( >-6.00 D,97 eyes). The time of epithelial healing, postoperative syndrome, postoperative visual acuity, refraction, intraocular pressure (IOP) , the safe index, the efficacy index and haze were evaluated at 1,3,6,12 months postoperatively. The written informed consent was obtained from each individual before surgery. Results After operation, 20 eyes ( 18.02% ) of lower myopia group and 29 eyes (29.90%) of high myopia group had obvious pain, presenting statistically significant difference between two groups (X2 = 4. 060, P<0.05 ). The mean time of epithelial healing was (5.49±0. 83 )days in lower myopia group and (5.85± 0.68 )days in high myopia group with a delayed epithelial healing time in high myopia group( u= 3. 377 ,P<0.05 ).One year after the treatment,the uncorrected visual acuity( UCVA ) ≥ 1. 0 was 90. 99% ( 101 eyes) in lower myopia group and 75.26% ( 73 eyes) in high myopia group, and 9.91% ( 11 eyes) and 15.46% ( 16 eyes) of the eyes improved byl line or more in best spectacle corrected visual acuity(BCVA) ;whereas 3.60% (4 eyes)and 6. 18% (6 eyes)lost a line or more. 91.89% ( 102 eyes) and 85.57% (83 eyes) in both groups gained within 1.00 D of the attempted correction. The safety index and efficacy index were 1.04 and 0. 98 in lower myopia group,and 1. 01 and 0. 96 in high myopia group without statistically significant difference( P>0. 05 ). haze occurred in 6 eyes in lower myopia group and 9 eyes in high myopia group and the difference in haze grading was not statistically significant between two groups ( P>0. 05 ). The high intraocular pressure appeared in 10 eyes and 9 eyes in low myopia group and high myopia group respectively during the fellow up duration and back to normal after topical use of timolol. Conclusion Epi-LASIK is an effective and safe method for correction of different diopters of myopia because of its mild symptom and lower incidence of haze.
5.Effect of wearing of soft corneal contact lens for long term on apoptosis of corneal epithelial cell
Xu, JIA ; Zhi-min, LI ; Hao, GU
Chinese Journal of Experimental Ophthalmology 2013;(7):674-677
Background Wearing of soft contact lens,as one of the important methods to correct ametropia,has been widely applied at present.The clinically deleterious effects of soft contact lens have been reported,but researches about influence of apoptosis of corneal epithelial cells are scant.Objective This study was to detect and compare the ratio of apoptosis of corneal epithelial cells between the patients with contact lens wearing and without contact lens wearing,and explore the influence of soft contact lens wearing for long term on growth of corneal epithelial cells after injury.Methods A retrospective nest case-controlled study was designed.Forty eyes of 20 myopic patients with wearing of soft contact lens for ≥5 years and 40 eyes of 20 myopic patients without wearing of soft contact lens were included in Affiliated Hospital of Guiyang Medical College.All the patients received the off-flap epipolis laser in situ keratomileusis (Epi-LASIK) from 2010 October to 2011 June.The corneal flaps were collected during the surgery.The apoptosis of corneal epithelial cells was detected by flow cytometry(FCM),and the difference of apoptotic proportion between the two groups was compared using independent sample t test.Results The FCM scatter plot showed that compared to the without contact lens wearing group,the early stage of apoptotic cells with high staining annexin V and low staining proaium iodide (PI) were much more,and survival cells with low staining annexin V and PI were less,and necrotic and late stage of apoptotic cells with high staining of annexin V/PI were more in the with contact lens wearing group.The early stage of apoptosis proportion of corneal epithelial cells was (11.23 ± 5.31)% in the with contact lens wearing group,and that in the without contact lens wearing group was (7.31± 5.43)%,showing a significant difference between them (t=2.754,P=0.008).Conclusions A long term wearing of contact lens induce more apoptosis of corneal epithelial cells,which can result in a disorder of structure and function of ocular surface during the wound healing stage.
6.Application of hand-held autorefractor in physical examination on candidates of pilots
Jing, XU ; Min-Hao, LI ; Peng, PENG
International Eye Science 2015;(8):1483-1485
AIM:To compare the difference between diopter of refration measured after cycloplegic mydriasis with retinoscopy and hand-held autorefractor so as to explore the feasibility of using hand - held autorefractor for refraction screening in cadet candidates.
METHODS:Respectively using hand-held autorefractor and streak retinoscope to do optometry examination in 317 cadet candidates students ( 634 eyes ) after mydriasis. Main index of refraction values ( spherical, cylindrical mirror degree and axial) were analyzed by difference test and correlation analysis. And the elimination rate was comparatively analyzed.
RESULTS: Diopters of sphere and cyclic refraction measured by hand-held autorefration were significantly higher than those by retinoscopy ( P< 0. 05 ), but the correction analysis showed that there was high correlation (r=0. 733, 0. 694), axial of refration measured by these two methods were non - significant ( P > 0. 05 ). The disqualifying rate using autorefraction was much higher than that using retinoscopy. It was easy to be wrongly eliminated.
CONCLUSION:Because of the high correlation between diopters of autorefraction measured by retinascopy and autorefractor, autorefraction has application value in refraction screening in cadet candidates with normal vision.
7. Study on quality control of Chinese herbal pieces based on Q-marker of Chinese materia medica
Chinese Traditional and Herbal Drugs 2017;48(9):1699-1708
Decoction pieces are the crude materials of Chinese medicinal granule, herbal decoction, and Chinese patent medicine. Its quality directly affects the quality of the three major traditional Chinese medicine products. As the intermediate link of "traditional Chinese medicinal materials-Decoction pieces-Chinese patent medicine" industry chain, the quality is very important. However, the quality control of Chinese materia medica (CMM) products has been dominated by traditional Chinese medicinal materials in recent decades. Though the quality control of Chinese herbal pieces is paid gradually more attention in the industry, it still can not reflect its own characteristics. The lack of scientificity, effectiveness, and rationality seriously affects the healthy development of CMM industry. Academician Chang-xiao Liu first proposed the new concept of "quality marker of CMM" in 2016, which caused a strong reaction. This paper reviewed and analyzed the current situation of the quality standard of CMM industry in detail, combined the research approach of "quality marker of CMM" with the characteristics of decoction pieces, in order to form the new idea of "quality marker of decoction pieces". The purpose is to stimulate thinking and resonance of the experts in the field of Chinese herbal pieces, to promote the improvement of quality control methods of Chinese herbal pieces, and to ensure the rapid development of CMM products industry.
8.The diagnostic value of 18F-FDG PET/CT in the localization of ectopic adrenocorticotrophic hormone-secreting tumors
Min, ZHANG ; Hao-ping, XU ; Biao, LI
Chinese Journal of Nuclear Medicine 2010;30(5):329-332
Objective To investigate the diagnostic value of 18F-fluorodeoxyglucose (FDG) PET/CT in the localization of ectopic adrenocorticotrophic hormone ( ACTH)-secreting tumors. Methods Seven patients with ectopic ACTH syndrome (confirmed by clinical symptom, biochemical data or bilateral simultaneous inferior petrosal sinus sampling) were included, 4 males and 3 females with age ranged 27-63 years old.All patients were examined with head MR, chest and abdomen CT, abdomen ultrasonography, and whole body 18F-FDG PET/CT. Location, size, and the maximum standardized uptake value (SUVmax) of the tumor were measured. Results 18 F-FDG PET/CT detected three ectopic ACTH-secreting tumors with the sizes 1. 1 cm×1.0 cm (SUVmax =9.4), 1.5 cm×1.1cm (SUVmax =6.4), and 1.6 cm ×1.5 cm (SUVmax =12.0). The pathological findings of the three tumors were thymoma, lung carcinoid, and mediastinal carcinoid respectively. Conclusion 18 F-FDG PET/CT may help the localization of ecto pic ACTH-secreting tumors .
9.Correlation between senile mild cognitive impairment and metabolize of oxygen-derived free radicals,acetylcholinesterase,blood lipids and inflammatory mediator
Hao LI ; Min WU ; Mingjiang YAO
Journal of Clinical Neurology 1993;0(03):-
Objective To study the correlation between senile mild cognitive impairment (MCI) and metabolize of oxygen-derived free radicals, acetylcholinesterase(AchE), blood lipids and inflammatory mediator. Methods Memory,the levels of superoxide dismutase (SOD), malondialdehyde (MDA), AchE, blood lipids, IL-1? and IL-6 of MIC group(45 cases) and elder healthy group(45 controls) were measured, funther compare and correlative analysis were made.Results Compared with elder healthy group, memory score in each item and memory quotient in MCI group were significantly lower (allP
10.Laparoscopic Ovarian Drilling for the Treatment of Polycystic Ovarian Syndrome with Infertility:Report of 51 Cases
Pengyan QIAO ; Min HAO ; Weihong ZHAO
Chinese Journal of Minimally Invasive Surgery 2001;0(05):-
Objective To explore the value of laparoscopic ovarian drilling in the treatment of polycystic ovarian syndrome with infertility.Methods The clinical data of 51 patients with polycystic ovarian syndrome with infertility undergone laparoscopic ovarian drilling were reviewed.The Serum concentrations of follicle-stimulating hormone(FSH),luteinizing hormone(LH),androgen(T),and estradiol(E2) were measured before and after the operation in all of the cases.Meanwhile,ovarian follicular development and pregnancy rate were observed during follow-up.Results Significantly decreased levels of FSH,LH,LH /FSH,and T were observed after the laparoscopic ovarian drilling in the patients(P