Aim To investigate the effects of com-bined treatment of SAHA and TRAIL on human breast cancer ER positive cell line MCF-7 . Methods MCF-7 cells were treated with SAHA and/or TRAIL. The inhibitory rates were detected by real-time cell prolifer-ation assays. Morphology changes of MCF-7 cells were observed through time-lapse live cell imaging acquisi-tion. Results Real-time cell proliferation assays showed that the anti-tumor efficacy of SAHA was sig-nificantly enhanced in combination with TRAIL. The results of time-lapse live cell imaging acquisition dem-onstrated that, with treatment of SAHA and TRAIL, the growth inhibition of MCF-7 cells was more obvious than that of in TRAIL or SAHA treatment alone. Con-clusion The combination treatment of SAHA and TRAIL has a synergistic effect of growth inhibition on breast cancer MCF-7 cells.

Vertigo is an erroneous perception of movement resulted from the disorder of spatial orientation. The diagnosis and treatment of vertigo is complexand it is urgent to pay more attention on the research in this disease and standardize the management protocol.
Humans ; Vertigo ; diagnosis ; therapy

Humans ; Voice ; Voice Disorders

Head and Neck Neoplasms ; surgery ; Humans

Humans ; Respiratory System ; anatomy & histology ; physiopathology ; Sleep Apnea Syndromes ; pathology ; physiopathology ; surgery

Endoscopy ; Humans ; Otorhinolaryngologic Surgical Procedures ; Skull Base ; surgery

Endoscopy ; trends ; Humans ; Otorhinolaryngologic Surgical Procedures ; methods ; Sinusitis ; surgery

Humans ; Sleep Apnea Syndromes

Endoscopy ; Evidence-Based Medicine ; Humans ; Nose ; surgery ; Otorhinolaryngologic Surgical Procedures ; trends