1.The Incidence of the Expression of Epstein-Barr Virus in Lymphomatoid Papulosis and Cutaneous CD30+ Anaplastic Large Cell Lymphoma in Korea.
You Chan KIM ; Woo Ick YANG ; Min Geol LEE ; Sang Gun PARK ; Soo Nam KIM ; Kwang Hyun CHO ; Seok Jong LEE ; Mi Woo LEE ; Jai Kyoung KOH
Korean Journal of Dermatology 2005;43(12):1596-1602
No abstract available.
Incidence
2.Epidermotropic Metastatic Melanoma Clinically Resembling Agminated Spitz Nevi.
Hee Joo KIM ; Byoung Joon SO ; Min Gun YOU ; Il Hwan KIM
Annals of Dermatology 2014;26(5):628-631
Herein, we report a 36-year-old Asian male patient who presented with grouped multiple erythematous waxy papules and nodules on his right medial thigh. He had undergone amputation of the right second toe because of a stage IIa malignant melanoma, 3 years previously. At the time of surgery for the primary tumor, right inguinal lymph node dissection revealed no nodal involvement. Three years after the diagnosis of the primary tumor, crops of multiple erythematous papules and nodules developed. Initial histopathologic evaluation of the papules showed nests of small epithelioid cells similar to compound nevi. However, cytologic features, including high mitotic figures, lack of maturation, and some hyperchromatic nuclei suggested metastatic melanoma. In addition to the pathologic findings, the tumors were on the right thigh, which was the same side as the primary malignant melanoma. The patient underwent wide excision of the tumor and split-thickness skin grafting.
Adult
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Amputation
;
Asian Continental Ancestry Group
;
Diagnosis
;
Epithelioid Cells
;
Humans
;
Lymph Node Excision
;
Male
;
Melanoma*
;
Nevus*
;
Skin Transplantation
;
Thigh
;
Toes
3.Changes of Corticotropin-Releasing Factor(CRF) and Neuropeptide Y(NPY) of Rats in Response to Footshock or Reexposure to Conditions Previously Paired with Footshock.
Kyung Ho SHIN ; Sung Jin KIM ; Kuem Ju LEE ; Seung Gun SHIN ; You Chan SHIN ; Min Soo LEE
Journal of the Korean Society of Biological Psychiatry 2003;10(1):62-69
Corticotropin-releasing factor(CRF) and neuropeptide Y(NPY) are known to play important roles in mediating stress responses and stress-related behavior. To elucidate the role of neuropeptides in response to the condition that had paired with traumatic event, we observed the changes of CRF and NPY by immunohistochemistry using a conditioned footshock paradigm. Male Sprague-Dawley rats were placed in a shuttle box and exposed to 20 pairings of a tone(< 70dB, 5sec) followed by a footshock(FS, 0.8mA, 1sec) over 60min. A second group was exposed to the tone-footshock pairings, returned to the homecage for 2days, and then reexposed to the test chamber and 20tones alone for 60min, prior to sacrifice. Control groups were : a) sacrificed without exposure to FS ; b) exposed to the tone-footshock pairings and then sacrificed two days later ; or c) exposed to the chamber and tones alone, returned to the homecage for 2days and then reexposed to the chamber and 20tones over 60min prior to sacrifice. CRF was increased in animals exposed to FS or the aversive condition(context and tone) that had paired to FS in bed nucleus of the stria terminalis (BNST) compared to the control. NPY was increased by FS in amygdala and PVN, but the condition previously associated with FS results in slight increase only in amygdala area. These results suggest that the BNST appears to be the mostly involved neural circuit in response to explicit cues previously paired with footshock. Moreover, this study raise the possibility that increased CRF peptide in the BNST in response to re-exposure to the aversive condition may underlie, in part, the experience of conditioned fear-related anxiety behavior.
Amygdala
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Animals
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Anxiety
;
Cues
;
Humans
;
Immunohistochemistry
;
Male
;
Negotiating
;
Neuropeptides*
;
Rats*
;
Rats, Sprague-Dawley
4.A Case of Hereditary Benign Telangiectasia without Family History
Daelyong HA ; Hyunju JIN ; Hyangsuk YOU ; Woo Haing SHIM ; Jeong Min KIM ; Gun Wook KIM ; Hoon Soo KIM ; Hyun Chang KO ; Moon Bum KIM ; Byung Soo KIM
Korean Journal of Dermatology 2018;56(1):76-78
No abstract available.
Humans
;
Telangiectasis
5.Cutaneous Abscess as a Complication of Bisphosphonate-Related Osteonecrosis of the Jaw.
Min Young YANG ; Hyunju JIN ; Hyang Suk YOU ; Woo Haing SHIM ; Jeong Min KIM ; Gun Wook KIM ; Hoon Soo KIM ; Hyun Chang KO ; Moon Bum KIM ; Byung Soo KIM
Annals of Dermatology 2018;30(2):243-245
No abstract available.
Abscess*
;
Bisphosphonate-Associated Osteonecrosis of the Jaw*
6.Congenital Melanocytic Nevus with Secondary Cutaneous Mucinosis in a Child.
Woo Il KIM ; Min Young YANG ; Tae Wook KIM ; Seong Min PARK ; Hyun Ju LEE ; HyunJu JIN ; Hyang Suk YOU ; Woo Haing SHIM ; Gun Wook KIM ; Hoon Soo KIM ; Byung Soo KIM ; Moon Bum KIM ; Hyun Chang KO
Korean Journal of Dermatology 2018;56(5):346-347
No abstract available.
Child*
;
Humans
;
Mucinoses*
;
Nevus, Pigmented*
7.Infantile Intertriginous Xanthoma with Type IIa Hyperlipoproteinemia without Family History
Geun Hwi PARK ; Woo Il KIM ; Min Young YANG ; Won Ku LEE ; Tae Wook KIM ; Sung Min PARK ; Hyun Joo LEE ; Gun Wook KIM ; Hoon Soo KIM ; Hyun Chang KO ; Byung Soo KIM ; Moon Bum KIM ; Hyang Suk YOU
Korean Journal of Dermatology 2019;57(2):99-100
No abstract available.
Humans
;
Hyperlipoproteinemia Type II
;
Xanthomatosis
8.Loquat (Eriobotrya japonica) leaf extract inhibits the growth of MDA-MB-231 tumors in nude mouse xenografts and invasion of MDA-MB-231 cells.
Mi Kyoung YOU ; Min Sook KIM ; Kyu Shik JEONG ; Eun KIM ; Yong Jae KIM ; Hyeon A KIM
Nutrition Research and Practice 2016;10(2):139-147
BACKGROUND/OBJECTIVES: The present study was conducted to examine the inhibitory effect of loquat leaves on MDA-MB-231 cell proliferation and invasion. MATERIALS/METHODS: Female athymic nude mice were given a subcutaneous (s.c.) inoculation of MDA-MB-231 cells and randomly grouped to receive a s.c. injection of either 500 mg/kg ethanol, water extract or vehicle five times a week. Tumor growth, mitotic rate and necrosis were examined. MDA-MB-231 cells were cultured with DMSO or with various concentrations of loquat water or ethanol extract. Proliferation, adhesion, migration, invasion and matrix metalloproteinase (MMP) activity were examined. RESULTS: Tumor growth of xenograft nude mouse was significantly reduced by loquat extracts. The results of mitotic examination revealed that loquat extracts reduced tumor cell division. Both ethanol and water extracts significantly inhibited MDA-MB-231 cell proliferation. The protein expression of ErbB3 was significantly down-regulated by loquat leaf extracts. Loquat leaf extracts increased apoptosis of MDA-MB-231 cells following 24 hour incubation and the ethanol extract was more potent in inducing apoptosis than the water extract. Furthermore, loquat extracts inhibited adhesion, migration and invasion of MDA-MB-231 cells. MMP activity was significantly inhibited by loquat extracts. CONCLUSION: Our results show that extracts of loquat inhibit the growth of tumor in MDA-MB-231 xenograft nude mice and the invasion of human breast cancer cells, indicating the inhibition of tumor cell proliferation and invasion.
Animals
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Apoptosis
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Breast Neoplasms
;
Cell Division
;
Cell Proliferation
;
Dimethyl Sulfoxide
;
Eriobotrya*
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Ethanol
;
Female
;
Heterografts*
;
Humans
;
Mice
;
Mice, Nude*
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Necrosis
;
Water
9.Eruptive Melanocytic Nevi Induced by Radotinib.
Won Ku LEE ; Hyunju JIN ; Hyang Suk YOU ; Woo Haing SHIM ; Jeong Min KIM ; Gun Wook KIM ; Hoon Soo KIM ; Hyun Chang KO ; Byung Soo KIM ; Moon Bum KIM
Korean Journal of Dermatology 2017;55(10):706-708
No abstract available.
Leukemia, Myelogenous, Chronic, BCR-ABL Positive
;
Nevus, Pigmented*
10.Five Cases of Phytophotodermatitis Caused by Fig Leaves and Relevant Literature Review.
Jin Hwa SON ; Hyunju JIN ; Hyang Suk YOU ; Woo Haing SHIM ; Jeong Min KIM ; Gun Wook KIM ; Hoon Soo KIM ; Hyun Chang KO ; Moon Bum KIM ; Byung Soo KIM
Annals of Dermatology 2017;29(1):86-90
Phytophotodermatitis is a condition caused by sequential exposure to photosensitizing substances present in plants followed by ultraviolet light. Several plants (e.g., limes, celery, fig, and wild parsnip) contain furocoumarin compounds (psoralens). It is important for dermatologists to be aware of phytophotodermatitis because it may be misdiagnosed as cellulitis, tinea, or allergic contact dermatitis. We present five patients with a sharply defined erythematous swollen patch with bullae on both feet. They described soaking their feet in a fig leaves decoction to treat their underlying dermatologic diseases. Within 24 hours, all patients had a burning sensation in their feet, and erythema and edema had developed on the feet dorsa with exception of the portion of the skin covered by the sandals. Histopathologic examinations revealed sub-epithelial blisters with intensive epidermal necrosis. Phytophotodermatitis was ultimately diagnosed and, after several days, the patients' skin lesions began to recover upon treatment with systemic and topical corticosteroids. Unfortunately, since there are no studies providing sufficient evidence on the benefits of fig leaves, they should be used with caution.
Adrenal Cortex Hormones
;
Apium graveolens
;
Blister
;
Burns
;
Cellulitis
;
Citrus aurantiifolia
;
Dermatitis, Allergic Contact
;
Edema
;
Erythema
;
Ficus
;
Foot
;
Humans
;
Necrosis
;
Photosensitivity Disorders
;
Sensation
;
Skin
;
Tinea
;
Ultraviolet Rays