1.A clinical study of pseudotumor of the orbit.
Yang Gi MIN ; Ic Tae KIM ; Won Seok YU
Korean Journal of Otolaryngology - Head and Neck Surgery 1991;34(6):1242-1246
No abstract available.
Orbit*
3.Factors Predicting Resistance to Intravenous Immunoglobulin Treatment and Coronary Artery Lesion in Patients with Kawasaki Disease: Analysis of the Korean Nationwide Multicenter Survey from 2012 to 2014
Min Kyu KIM ; Min Seob SONG ; Gi Beom KIM
Korean Circulation Journal 2018;48(1):71-79
BACKGROUND AND OBJECTIVES: Approximately 10–15% of children with Kawasaki disease (KD) do not respond to initial intravenous immunoglobulin (IVIG) and have higher risk for coronary artery lesion (CAL). The aim of this study was to identify predictive factors from laboratory findings in patients who do not respond to IVIG treatment and develop CAL from KD. METHODS: We retrospectively collected nationwide multicenter data from the Korean Society of Kawasaki Disease and included 5,151 patients with KD between 2012 and 2014 from 38 hospitals. RESULTS: Among 5,151 patients with KD, 524 patients belonged to the IVIG-resistant group. The patients in the IVIG-resistant group had a significantly higher serum N-terminal pro-brain natriuretic peptide (NT-proBNP) level (1,573.91±3,166.46 vs. 940.62±2,326.10 pg/mL; p < 0.001) and a higher percentage of polymorphonuclear neutrophils (PMNs) (70.89±15.75% vs. 62.38±32.94%; p < 0.001). Multivariate logistic regression analyses revealed that significantly increased PMN, NT-proBNP, C-reactive protein (CRP), aspartate aminotransferase (AST), and alanine aminotransferase (ALT) were the predictors of IVIG resistance (p < 0.05). Multivariate logistic regression analyses also showed that only CRP was associated with the risk of CAL (p < 0.01), while PMN, NT-proBNP, AST, and ALT were not. CONCLUSIONS: Elevated PMN, serum NT-proBNP, CRP, AST, and ALT levels are significantly associated with IVIG resistance in patients with KD. Moreover, serum CRP is significantly increased in patients with KD with CAL.
Alanine Transaminase
;
Aspartate Aminotransferases
;
C-Reactive Protein
;
Child
;
Coronary Artery Disease
;
Coronary Vessels
;
Humans
;
Immunoglobulins
;
Immunoglobulins, Intravenous
;
Logistic Models
;
Mucocutaneous Lymph Node Syndrome
;
Natriuretic Peptide, Brain
;
Neutrophils
;
Retrospective Studies
4.Factors Predicting Resistance to Intravenous Immunoglobulin Treatment and Coronary Artery Lesion in Patients with Kawasaki Disease: Analysis of the Korean Nationwide Multicenter Survey from 2012 to 2014
Min Kyu KIM ; Min Seob SONG ; Gi Beom KIM
Korean Circulation Journal 2018;48(1):71-79
BACKGROUND AND OBJECTIVES:
Approximately 10–15% of children with Kawasaki disease (KD) do not respond to initial intravenous immunoglobulin (IVIG) and have higher risk for coronary artery lesion (CAL). The aim of this study was to identify predictive factors from laboratory findings in patients who do not respond to IVIG treatment and develop CAL from KD.
METHODS:
We retrospectively collected nationwide multicenter data from the Korean Society of Kawasaki Disease and included 5,151 patients with KD between 2012 and 2014 from 38 hospitals.
RESULTS:
Among 5,151 patients with KD, 524 patients belonged to the IVIG-resistant group. The patients in the IVIG-resistant group had a significantly higher serum N-terminal pro-brain natriuretic peptide (NT-proBNP) level (1,573.91±3,166.46 vs. 940.62±2,326.10 pg/mL; p < 0.001) and a higher percentage of polymorphonuclear neutrophils (PMNs) (70.89±15.75% vs. 62.38±32.94%; p < 0.001). Multivariate logistic regression analyses revealed that significantly increased PMN, NT-proBNP, C-reactive protein (CRP), aspartate aminotransferase (AST), and alanine aminotransferase (ALT) were the predictors of IVIG resistance (p < 0.05). Multivariate logistic regression analyses also showed that only CRP was associated with the risk of CAL (p < 0.01), while PMN, NT-proBNP, AST, and ALT were not.
CONCLUSIONS
Elevated PMN, serum NT-proBNP, CRP, AST, and ALT levels are significantly associated with IVIG resistance in patients with KD. Moreover, serum CRP is significantly increased in patients with KD with CAL.
5.Proliferating cell nuclear antigen and nucleolar organizer region in cervical intraepithetial neoplasia.
Chang Hong KIM ; Seung Kyu HWANG ; Gi Yeon HONG ; Heung Gon KIM ; Boo Ki MIN
Korean Journal of Obstetrics and Gynecology 1993;36(7):2328-2338
No abstract available.
Nucleolus Organizer Region*
;
Proliferating Cell Nuclear Antigen*
6.Proliferating cell nuclear antigen and nucleolar organizer region in cervical intraepithetial neoplasia.
Chang Hong KIM ; Seung Kyu HWANG ; Gi Yeon HONG ; Heung Gon KIM ; Boo Ki MIN
Korean Journal of Obstetrics and Gynecology 1993;36(7):2328-2338
No abstract available.
Nucleolus Organizer Region*
;
Proliferating Cell Nuclear Antigen*
7.Percutaneous transluminal balloon valvuloplasty for congenital pulmonary valvular stenosis.
Sung Min CHOI ; Gi Hong KIM ; Sang Bum LEE ; Doo Hong AHN ; Yong Joo KIM
Journal of the Korean Pediatric Society 1991;34(3):311-316
No abstract available.
Balloon Valvuloplasty*
;
Constriction, Pathologic*
8.Hypereosinophilic syndrome: Clinical, laboratory, and imaging manifestations in patients with hepatic involvement.
Gi Beom KIM ; Ok Hwoa KIM ; Jong Min LEE ; Yeong Soon SUNG ; Duk Sik KANG
Journal of the Korean Radiological Society 1993;29(4):757-764
The hyperosinophilic syndrome (HES) commonly involves liver and spleen but only a few literature has reported the imaging features. In this article, we present the imaging features of the liver and spleen in HES patients together with clinical and laboratory features. This study included 5 HES patients with hepatic involvement. Extensive laboratory tests including multiple hematologic, serologic, parasitologic, and immunologic examinations were performed. Imaging studies included CT, ultrasound (US) of upper abdomen and hepatosplenic scintigraphy. All patients were periodically examined by laboratory and imaging studies for 4 to 24 months. The common clinical presentations were weakness, mild fever, and dry cough. All patients revealed leukocytosis with eosinophilia of 40 to 80% and benign eosnophilic hyperplasia of the bone marrow. The percutaneous biopsy of the hepatic focal lesions performed in 2 patients showed numerous benign eosinophilic infiltrates and one of them revealed combined centrilobular necrosis of hepatocytes. All cases revealed hepatomegaly with multiple focal lesions on at least one of CT, US, or scintigraphy. These findings completely disappeared in 2 To 6 months following medication of corticosteroid or antihistamines. The HES involved the liver and CT, US, or scintigraphy. These findings completelydisappeared in 2 to 6 months following medication of corticosteroid or antihistamines. The HES involved the liver and CT, US, or scintigraphic studies showed hepatic multifocal lesions with hepatomegaly. Differential diagnoses of these findings should include metastatic disease, lymphoma, leukemia. candidiasis or other opportunistic infections.
Abdomen
;
Biopsy
;
Bone Marrow
;
Candidiasis
;
Cough
;
Diagnosis, Differential
;
Eosinophilia
;
Eosinophils
;
Fever
;
Hepatocytes
;
Hepatomegaly
;
Histamine Antagonists
;
Humans
;
Hypereosinophilic Syndrome*
;
Hyperplasia
;
Leukemia
;
Leukocytosis
;
Liver
;
Lymphoma
;
Necrosis
;
Opportunistic Infections
;
Radionuclide Imaging
;
Spleen
;
Ultrasonography
9.Hypereosinophilic syndrome: Clinical, laboratory, and imaging manifestations in patients with hepatic involvement.
Gi Beom KIM ; Ok Hwoa KIM ; Jong Min LEE ; Yeong Soon SUNG ; Duk Sik KANG
Journal of the Korean Radiological Society 1993;29(4):757-764
The hyperosinophilic syndrome (HES) commonly involves liver and spleen but only a few literature has reported the imaging features. In this article, we present the imaging features of the liver and spleen in HES patients together with clinical and laboratory features. This study included 5 HES patients with hepatic involvement. Extensive laboratory tests including multiple hematologic, serologic, parasitologic, and immunologic examinations were performed. Imaging studies included CT, ultrasound (US) of upper abdomen and hepatosplenic scintigraphy. All patients were periodically examined by laboratory and imaging studies for 4 to 24 months. The common clinical presentations were weakness, mild fever, and dry cough. All patients revealed leukocytosis with eosinophilia of 40 to 80% and benign eosnophilic hyperplasia of the bone marrow. The percutaneous biopsy of the hepatic focal lesions performed in 2 patients showed numerous benign eosinophilic infiltrates and one of them revealed combined centrilobular necrosis of hepatocytes. All cases revealed hepatomegaly with multiple focal lesions on at least one of CT, US, or scintigraphy. These findings completely disappeared in 2 To 6 months following medication of corticosteroid or antihistamines. The HES involved the liver and CT, US, or scintigraphy. These findings completelydisappeared in 2 to 6 months following medication of corticosteroid or antihistamines. The HES involved the liver and CT, US, or scintigraphic studies showed hepatic multifocal lesions with hepatomegaly. Differential diagnoses of these findings should include metastatic disease, lymphoma, leukemia. candidiasis or other opportunistic infections.
Abdomen
;
Biopsy
;
Bone Marrow
;
Candidiasis
;
Cough
;
Diagnosis, Differential
;
Eosinophilia
;
Eosinophils
;
Fever
;
Hepatocytes
;
Hepatomegaly
;
Histamine Antagonists
;
Humans
;
Hypereosinophilic Syndrome*
;
Hyperplasia
;
Leukemia
;
Leukocytosis
;
Liver
;
Lymphoma
;
Necrosis
;
Opportunistic Infections
;
Radionuclide Imaging
;
Spleen
;
Ultrasonography
10.US findings of thyroid carcinomas developed in multinodular goiters.
Young Soon SUNG ; Gi Bum KIM ; Jong Min LEE ; Tae Hun KIM ; Duk Sik KANG
Journal of the Korean Radiological Society 1992;28(5):671-678
Primary role of ultrasound in patients with thyroid nodule is to determine the multiplicity and detect occult carcinoma. We analyzed US findings of 53 thyroid carcinomas with multiple nodular lesions from january 1988 to december 1991. The results were as follows: 1. 109 malignant nodules in 53 cases and 24 benign in 23 were comfirmed. 2. The nature of the masses were solid in 72 malignant nodules (74.2%), and complex in 25 (25.8%) of which 19 were predominantly solid. 3. The echo pattern of the solid and solid predominant masses were hypoechoic in 78 malignant nodules (80.4%), hyperechoic in 10 (10.3%), and isoechoic in 3 (9.3%) 4. Internal punctate calcifications within the masses were observed in 31 malignant nodules (31.9%). 5. Halo sign was present in 16 malignant nodules(16.5%). 6. The preoperative sonographic diagnosis of thyroid carcinoma was made in 39.4% of 53 cases with multiple nodules on US. In conclusion, the number, and halo formation of nodules were insignificant to differentiate the benign nodule from the malignant. The heterogeneous hypoechoic nodules with size greater than 4cm, multiple stippled calcifications, displacement of the trachea or other surrounding structures of combined lymph node enlargements seem to indicate the possibility of malignancy.
Diagnosis
;
Goiter*
;
Humans
;
Lymph Nodes
;
Thyroid Gland*
;
Thyroid Neoplasms*
;
Thyroid Nodule
;
Trachea
;
Ultrasonography