BACKGROUND: Squamous cell caircinoma(SCC) often shows acantholysis as a result of degenerative changes of neoplastic cells. Regurding the acantholytic changes of SCC most textbooks and literature describe the acantholysis-associated tubular or alveolar structures, which are diagnostic features of adenoid SCC. But the acantholytic changes of SCC are not always assaciated with tubular or alveolar structres. The general and detailed histologic features of acantholysis of SCC have not been reported. OBJECTIVE: We analyzed the histologic features of acantholysis of SCC . MEHTODS: Twenty six biopsy specimens from 26 patients with SCC were studied for the distributions and sites of acantholysis such as lefts and tubular or alveolar structurs on routine histologic staining. RESULTS: All 26 biopsy specimens showed acantholysis in their tumors ocal acantholysis was found in 12 cases, and diffuse, widesprcad acantholysis was found in 14 cascs. The foci of acantholysis were in the surface epidermis in 9 cases, in the follicular wall in 5 cases, and in both the surface epidermis and the follicuar wall in 12 cases. The types of acantholytic cells were either dyskeratotic cells or non-dyskeratotic squamous cells. Tuthular or alveolar structures were found in 5 cases. Clefts were found in 12 cases, one in the subcomealarea, the other 11 were within tumor mases, and one of them showed Darier-like feature with papillary projections of neoplastic cells into thc lumens. CONCLUSION: The acantholytic hanges of the SCC are more comrr on y found than expected. The acantholytic changes involve not only dyskeratotic cells but also non-dysL eratotic cells and often show glandular structures and clefts.
Acantholysis* ; Adenoids ; Biopsy ; Carcinoma, Squamous Cell* ; Dronabinol ; Epidermis ; Humans

Eighty-two strains of Escherichia coli isolated from urine specimens in Pusan University Hospital, were serotyped and analyzed for plasmid DNA profiles, PFGE profiles, MRHA of human blood cells, HEp-2 cell adherence ability and reactivity to bfpA, LT, STh and STp DNA probes. The following results were obtained. Fifty-three of the eighty-two strains belonged to thirteen different 0 serotypes, twenty-nine strains could not be typed with the antisera used. Thirty strains (43.9%) were hemolysin producer. MRHA is present on twenty-nine strains (35.37%) of eighty-two strains. MRHA positive strains carry a plasmid of 60MDa, a putative factor involved in adherence. This plasmid might be specific for MRHA positive strains. MRHA positive strains were observed in serotype 01, 018, 055, 086a, 0119, 0126, and 0142. Twenty-six strains of E. coli showed three patterns of adherence to HEp-2 cells namely, localized, diffuse, and aggregative adhesion. Twenty-two strains hybridized with the bfpA probe, while all eighty-two strains did not hybridize with the probes, LT, STh, STp. The restriction fragment patterns of chromosomal DNA digested with AotI analysed by PFGE of hemolysin-producing E. coli ten strains were compared with eight different types. Three of E. coli serotype 01, 08 and 0126 showed the same chromosomal DNA fragment patterns.
Blood Cells ; Busan ; DNA ; DNA Probes ; Escherichia coli* ; Escherichia* ; Humans ; Immune Sera ; Plasmids ; Serotyping*

Basal cell carcinoma is the most common skin cancer, but it rarely metastasizes. Metastatic basal cell carcinoma (MBCC) is rare in terms of incidence as well as absolute numbers. We present a case of 67-year-old woman who had a dirty oozing, ulcerated, tumor mass on the vertex and suffered from dyspnea and mild lumbago. The diagnosis of MBCC was based on clinical, radiological, and histopathological findings. To our knowledge, the occurrence of MBCC has not been reported in the Korean literatures. So we reported herein this case of MBCC of the lung and the bone.
Aged ; Carcinoma, Basal Cell* ; Diagnosis ; Dyspnea ; Female ; Humans ; Incidence ; Low Back Pain ; Lung ; Skin Neoplasms ; Ulcer

In 1978, Bjornberg and Friis reported 32 patients with persistent pusi ulosis(PP) on distal extremities, of whom 13 patients were initially diagnosed as scabies. In 1984, Elpern described 7 patients with infantile acropustulosis(IA), of whom 4 patients had antecedant scabies. We report herein a case of PP, which was found in a 18 month-old mal who was treated for scabies at the age of 5 month and 12 month. The pruritic vesicopustules dev',lo ed 2 months after the second treatment for scabies and relapsed for 4 months. We also discuss the relationship between scabies and PP and also between PP and IA.
Extremities ; Humans ; Infant ; Scabies*

We present two cases of oral lichen planus associated with chronic liver diseases. One patient was a 56-year-old man that had advanced liver cirrhosis with hepatitis B viral infection, and the other, a daughter of patient 1, was identified as chronic active hepatitis with hepatitis B viral infection. Clinical and histopathological features of oral lesions were consistent with lichen planus in both cases.
Hepatitis B ; Hepatitis, Chronic ; Humans ; Lichen Planus ; Lichen Planus, Oral* ; Liver Cirrhosis ; Liver Diseases* ; Liver* ; Middle Aged ; Nuclear Family

A 37-year-old female presented with a lobulated 2.5 x 1.5cm sized tumor with several sat ellite papules on the left lateral malleolar area for 27 years. Hiopsy specimens from hoth the lobulated lesion and the satellite lesion showed findings similar with features of intradermal nevus.
Adult ; Female ; Humans ; Nevus, Intradermal*

BACKGROUND: CD34 is a 115 kD glycoprotein which is expressed on hematopoietic progenitor cells. It is also known as an immunohistochemical marker of endothelial cells. OBJECTIVE: This study was designed to investigate the patterns of CD34 expression on: (1) cutaneous benign and malignant vascular tumors and (2) on the mature and immature vessels of pyogenic grauloma and capillary hemangioma. METHOD: We performed immunoperoxidase staining using a monoclonal anti-CD34 antibody (QBEND/10) on formalin fixed, paraffin-embedded sections of 23 benign and malignant cutaneous vascular tumors. RESULTS: The results are summerized as follows: 1. In 3 cases of nevus flammeus and 6 cases of carvernous hemangioma, vascular endothelial cells of all hemangiomas showed CD34 expressions. In 5 cases of angiokeratoma, endothelial cells of hemangioma, did not express CD34. 2. In all 5 cases of pyogenic granulomas and one case of capillary hemangioma, endothelial cells of mature vessels, endothelial cells near the well-formed lumina and endothelial cells showing intracellular lumina showed strong positivity for CD34, wbile endothelial cells far from the lumina and endothelial cells without lumina formation mostly showed negative staining for CD34. 3. One cese of Kaposis sarcoma showed focall positivity for CD34 both in endothelial cells of the small, well-formed vessels and spindle cells. Two cases of angiosarcoma showed CD34 expression only in endothelial cells of well-formed, normal appearing vessels, whereas atypical endothelial cells of tumor vessels and spindle cells were negative for CD34. CONCLUSION: CD34 could be a marker for endothelium in mature, well-differentiated vascular structures and may serve as a marker of lumen formation or differentiation of endothelial cells.
Angiokeratoma ; Endothelial Cells ; Endothelium ; Formaldehyde ; Glycoproteins ; Granuloma, Pyogenic ; Hemangioma ; Hemangioma, Capillary ; Hemangiosarcoma ; Hematopoietic Stem Cells ; Negative Staining ; Port-Wine Stain ; Sarcoma, Kaposi

Intravenous pyogenic granuloma (IVPG) is a form of pyogenic granuloma (PG) in which the capillary proliferation is confined entirely within the lumen of a vein. It occurs typically in the neck and upper extremities. Histologically, this benign lesion is similar to PG of other localizations and is characterized by a lobular proliferation of capillaries growing in a sparsely cellular, edematous collagenous stroma. We report a case of IVPG developing in the palm, an unusual site of occurrence.
Capillaries ; Collagen ; Granuloma, Pyogenic* ; Neck ; Upper Extremity ; Veins

No abstract available.
Carcinoma* ; Nevus*

No abstract available.
Autopsy* ; Cardiomyopathies* ; Humans ; Infant, Newborn*