The model of lymphocyte differentiation described for Lukes-Collins' classification of non-Hodgkin's lymphoma is related particularly to morphological alterations of nuclei of follicular center lymphocytes by antigenic stimulation. The authors carried out ultrastructural and morphometric studies to investigate morphological alterations during lymphocyte transformation on the nuclear profiles of follicular center, parafollicular and mantle zone lymphocytes in ten tonsillectomy cases of chronic hypertrophic tonsillitis. The nuclear parameters measured included nuclear area, contour index, frequency invagination and cleft, depth of invagination and nuclear diameters. Follicular centers contained a mixed population of lymphocytes consisting of untransformed (type 1), partially transformed (type 2) and fully transformed (type 3) lymphocytes. During lymphocyte transformation in both follicular, and parafollicular and mantle zones, the nuclei had a gradual and progressive increase in size. The nuclear contour index of type 2 nuclei of both follicular and parafollicular and mantle zones tended to be higher than those of type 1 and 3, indicating a greater degree of irregularity and variability of nuclear profiles. Invaginated and cleaved lymphocytes were not confined to me transformed lymphocytes. A considerable portion of lymphocytes had invaginations and clefts in parafollicular and mantle zone as well as follicular center. No difference on the depth of invagination was noted in type 1, type 2 and type 3 lymphocytes. The results indicate that some promise of the Lukes-Collins conepts of follicular center cells and the process of lymphocyte transformation in follicular centers may be necessary to revise

No abstract available.
Extracorporeal Circulation* ; Plasma*

No abstract available.
Peritoneal Dialysis, Continuous Ambulatory* ; Peritonitis*

No abstract available.
Foot* ; Hand*

Tumor lysis syndrome is a life-threatening complication of anti-cancer therapy that typically occurs in patients with large, rapidly growing and treatment-sensitive tumors such as high-grade lymphomas and acute leukemias. However, its incidence in solid tumors has been known to be very low. Tumor lysis syndrome in solid tumors has a high mortality rate owing to the lack of prophylactic therapy to prevent this complication. We report a case of fatal tumor lysis syndrome developed during chemotherapy in extensive-stage small cell lung cancer, along with a brief review of the relevant literature considering the rarity of this manifestation in solid tumor.
Humans ; Incidence ; Leukemia ; Lymphoma, Non-Hodgkin ; Small Cell Lung Carcinoma ; Tumor Lysis Syndrome

The nodular form of muscular sarcoidosis is a rare malady that is often confused with a soft-tissue neoplasm or other lesion. Here, we present a case of nodular muscular sarcoidosis in the arms and legs of a 59-year-old woman. She presented at our hospital with a painless nodule in her left arm. Excision was performed and she was diagnosed with sarcoidosis. One year later, nodular sarcoidosis recurred in her arms and legs. After 2 months of steroid medication, the nodules disappeared. The patient has been followed for 2 years and no evidence of recurrence has been observed.
Arm ; Female ; Humans ; Leg ; Middle Aged ; Recurrence ; Sarcoidosis

PURPOSE: Chronic prostatitis displays various pathophysiologies due to various causes, and is a life time affliction, but the diagnosis and treatment are still unclear. Therefore, it is important to find if some elements influence the incidence and progress of the disease; attempts were made to recognize the risk factors for chronic prostatitis. MATERIALS AND METHODS: 184 chronic prostatitis patients were selected, and divided, after treatment, into the improvement (IG; n=147) and non-improvement groups (NIG; n=37). 40 healthy men were chosen as the control group (CG) for a comparative analysis. Subjects were investigated for their professional stati and form of work, driving, motorcycle or bicycle utilization, drinking, smoking, sex and their style of diet. RESULTS: The ratio of sedentary desk workers in the NIG (73.0%) was higher than in the other groups. The ratio of those that drove for more than 1 hour was much high in the NIG by 54.1%. The ratio of the people who ejaculated more than once a week, either through sexual intercourse or masturbation, was lower in the NIG by 56.5%, but that of people who ejaculated every day was higher in the NIG (13.5%). People drinking more than once a week was greater in the NIG (67.6%), and those who drank more than 1 bottle of Korean wine, Soju, were showed an expressively higher ratio in the NIG (72.0%). In relation to dietary behavior, the NIG showed a high ratio (73.0%) for a preference for salty food only. CONCLUSIONS: Factors that may influence the prognosis of chronic prostatitis are thought to be the form of profession, number ejaculations, frequency and amount of drinking, an a habit of eating salty food. Therefore, these factors should be considered together when looking for a cure for chronic prostatitis.
Coitus ; Diagnosis ; Diet ; Drinking ; Eating ; Ejaculation ; Humans ; Incidence ; Male ; Masturbation ; Motorcycles ; Prognosis ; Prostatitis* ; Risk Factors* ; Smoke ; Smoking ; Wine

No abstract available.
Animals ; Calcium* ; Clonidine* ; Ganglia, Spinal* ; Rats* ; Spinal Nerve Roots* ; Tetracaine*

The authors tried to evaluate the effect of the growth factors on cell proliferation in the human retina astrocyte culture. Each growth factor, EGF, bFGF, GGF, IGF-1 or PDGF, together with BrdU was added to astrocytes-enriched cultures in the serum-free media. The proliferating effect of each growth factor was evaluated by a double immunofluo- rescenece labelling for GFAP and BrdU. By and addition of each growth factor, the number of retinal astrocytes at the synthetic stage significantly increased than those of control group (p<0.01). In comparision, PDGF was more potent than IGF-1 (p<0.01). Above data extended the concept of astrocytic proliferation caused by several growth factors in human retinal injury.
Astrocytes ; Bromodeoxyuridine ; Cell Proliferation ; Culture Media, Serum-Free ; Epidermal Growth Factor ; Humans ; Insulin-Like Growth Factor I ; Intercellular Signaling Peptides and Proteins* ; Neuroglia* ; Retina ; Retinaldehyde*

PURPOSE: We evaluates if the administration of tamsulosin increases the efficacy of extracorporeal shock wave lithotripsy (ESWL) in the patients with upper ureteral stones and if this decreased the use of analgesic drugs after the procedure. MATERIALS AND METHODS: A total of 45 patients with stones 6-12mm in size that were located in the upper ureter were enrolled in the study. The patients were randomly divided into two groups. Group 1 (n=23) received 3 times a day oral treatment of 20mg caroverine (a spasmolytic drug). Group 2 (n=22) received one time a day oral therapy of 0.2mg tamsulosin. All the patients received oral treatment for 14 days. Both groups of patients were allowed to use 30mg ketorolac trimethamine intramuscular injections on demand. The endpoint of the study was the stone expulsion rate, the use of analgesics and the drug adverse effects during treatment. RESULTS: The average stone size was 7.9+/-2.79mm for group 1 and 8.2+/-3.14mm for group 2. No statistical difference between the two groups was found for the stone size, age and gender distribution. The expulsion rate was significantly higher in group 2 (90.9%) compared with group 1 (65.2%) (p=0.038). The average number of pain control injections was 0.78 for group 1 and 0.23 for group 2, and there was a statistically significant difference between the two groups (p=0.042). CONCLUSIONS: The use of tamsulosin proved to be effective and safe, as demonstrated by the increased stone expulsion rate and the lesser need for pain control than that when using just a spasmolytic drug for ESWL of upper ureter stones.
Analgesics ; Humans ; Injections, Intramuscular ; Ketorolac ; Lithotripsy* ; Shock* ; Ureter* ; Urinary Calculi