No abstract available.
Arthrogryposis* ; Humans ; Twins, Monozygotic*

No abstract available.
Female ; Humans ; Osteoporosis* ; Uterine Prolapse*

No abstract available.

Annular pustular psoriasis is a rare variant of the generalized pustular psoriasis characterized by annular lesions with rapidly evolving pustules, associated mild toxicity, and rapid response to therapy. We present a case of annular pustular psoriasis in a 17-year-old male, in whom no previous history of psoriasis was found. The skin lesions were characterized clinically by annular to gyrate erythematous lesions with pinpoint pustules near the periphery on both shoulders, upper arms, and back areas. The histology showed large intraepidermal spongiform pustules. Most of the skin lesions disappeared within 1 week with topical corticosteroid cream.

Progressive multifocal leukoencephalopathy (PML) is a demyelinating disease resulting from infection of oligodendrocytes with JC virus. PML was a rare disease, but nowadays not uncommon as AIDS prevailed. Histopathologic features of the affected lesion shows infiltrations of foamy macrophages and hyperchromatic, pleomorphic, reactive astrocytes that may raise the suspicion of a brain tumor. We recently met with 3 cases of PML. Two of the patients had AIDS and the other had been treated for lymphoma. All cases were diagnosed by histopathologic examination in stereotactic brain biopsies.
Acquired Immunodeficiency Syndrome ; Astrocytes ; Biopsy ; Brain ; Brain Neoplasms ; Demyelinating Diseases ; Humans ; Immunocompromised Host* ; JC Virus ; Leukoencephalopathy, Progressive Multifocal* ; Lymphoma ; Macrophages ; Oligodendroglia ; Rare Diseases

Hypertension is a well known causative factor of congestive heart failure and other cardiovascular disease, and usually induce myocardial hypertrophy. Recent study shows that some antihypertensive drugs may reduce the hypertrophied cardiac mass reversibly. And over the past some decades, increasing attention was focused on these drugs. These drugs include methyldopa, angiotensin converting enzyme inhibitor, calcium channel inhibitor, beta-adrenergic blocker, but diuretics and vasodilators were known not to reduce the hypertrophied ventricular mass. In this study, 46 hypertensive patients were managed by captopril, atenolol, or hydrochlorothiazide monotherapy. And wer estimated and follow up LV mass by echocardiography during 3 months. Captopril and atenolol group showed LV mass reduced, but hydrochlorothiazide group did not. LV mass was reduced more in captopril group than in atenolo group. In conclusion, we have been impressed by this study that diuretics monotherapy for hypertension shoud be reconsidered. And we concluded that drugs which can reduce myocardial mass shoud be chosen to control hypertension as a monotherapeutic drug or a additive drug.
Antihypertensive Agents ; Atenolol ; Calcium Channels ; Captopril ; Cardiovascular Diseases ; Diuretics ; Echocardiography ; Follow-Up Studies ; Heart Failure ; Humans ; Hydrochlorothiazide ; Hypertension* ; Hypertrophy ; Methyldopa ; Peptidyl-Dipeptidase A ; Vasodilator Agents

OBJECTIVE: We report the correlation between known risk factors for cerebrovascular disease and formation of multiple intracranial aneurysms. METHODS: We reviewed the medical records and outcomes of 524 patients who had undergone aneurysmal operation at our hospital between January 1996 and May 2001. Of 524 patients who had undergone operations with intracranial aneurysm, 130 patients had multiple intracranial aneurysms. The authors examined the correlations between the risk factors(patient age, sex, menopausal state of female patients, hypertension, cigarette smoking) and the presence of multiple intracranial aneurysms by using chi-square test retrospectively. RESULTS: The male to female ratio was about 1 : 2.05(male : female=129 : 265) for patients with single intracranial aneurysm, and male to female was about 1 : 3.06(male : female=32 : 98) for patients with multiple intracranial aneurysms. Among 256 female patients with single intracranial aneurysm, 182 patients(68.9%) were postmenopausal, and, among 98 female patients with multiple intracranial aneurysms, 81 patients(82.6%) were postmenopausal. The mean age of the patients with single intracranial aneurysm was 54 years, and, with multiple intracranial aneurysms, the mean age was 57.8 years. The presence of hypertension was found in 149 patients(37.8%) with single intracranial aneurysm, and, in 55 patinets (42.3%) with multiple intracranial aneurysms. Cigarette smoking was found in 116 patients(29.4%) with single intracranial aneurysm and 47 patients(36.1%) with multiple intracranial aneurysms. CONCLUSION: There is a significant correlation between menopausal state of female patients and presence of multiple intracranial aneurysms. However, gender, hypertension and smoking are not related to multiple intracranial aneurysms.
Aneurysm ; Female ; Humans ; Hypertension ; Intracranial Aneurysm* ; Male ; Medical Records ; Postmenopause ; Retrospective Studies ; Risk Factors* ; Smoke ; Smoking ; Tobacco Products

PURPOSE: Respiratory syncytial virus (RSV) can cause serious respiratory illnesses such as pneumonia, asthma, and bronchiolitis in infants and elderly or immunocompromised individuals. An RSV vaccine has yet to be developed; only prophylactic anti-RSV antibody is commercially available. So, we investigated whether our vaccine candidate is able to induce type 1 CD4+ T helper (Th1), CD8+ T-cell responses, and protective immunity without vaccine-enhanced disease (VED) against RSV. MATERIALS AND METHODS: We used RSV G protein fragment (Gcf A) with recombinant baculovirus capable of expressing the RSV M2 protein (Bac M2) as a vaccine candidate, and injected this vaccine (Gcf A/Bac M2) intramuscularly, and challenged with RSV intranasally into mice. Enzyme-linked immunosorbent assay, flow cytometry, plaque assay, and weight measurement were performed to confirm humoral immunity, cellular immunity, and protective immunity. RESULTS: The Gcf A/Bac M2 formulation induced a stronger IgG response to Gcf A than Gcf A inoculation alone, and the ratio of IgG1/IgG2a indicated that the responses shifted predominantly to Th1. In addition, both RSV G-specific Th1 responses and RSV M2-specific CD8+ T-cell responses were induced, and G protein-associated eosinophilic infiltration was suppressed compared to the control group. Moreover, the Gcf A/Bac M2 group showed effective protection after an RSV challenge. CONCLUSION: Bac M2 could serve as a vaccine with intrinsic adjuvant activity, and the Gcf A/Bac M2 shows promise as a vaccine candidate for inducing protective immunity without inciting VED.
Aged ; Animals ; Asthma ; Baculoviridae* ; Bronchiolitis ; Enzyme-Linked Immunosorbent Assay ; Eosinophils ; Flow Cytometry ; GTP-Binding Proteins* ; Humans ; Immunity, Cellular ; Immunity, Humoral ; Immunoglobulin G ; Infant ; Mice ; Pneumonia ; Respiratory Syncytial Viruses* ; T-Lymphocytes

Transcatheter arterial embolization (TAE) is widely used in the treatment of unresectable hepatocellular carcinoma. Its common complications are right upper quadrant pain, nausea, vomiting, and rare complications include focal pancreatic necrosis, gastric ulcer, renal failure, DIC, biliary tree necrosis and splenic infarction and so on. It has been reported that hepatobronchial fistula could develop as a pleuropulmonary complication of liver abscess. We report a case of hepatobronchial fistula caused by complicating liver abscess in a patient with hepatocellular carcinoma who was treated with TAE.
Biliary Tract ; Carcinoma, Hepatocellular* ; Dacarbazine ; Fistula* ; Humans ; Liver Abscess ; Nausea ; Necrosis ; Renal Insufficiency ; Splenic Infarction ; Stomach Ulcer ; Vomiting

Accidents, Occupational ; Accidents, Traffic ; Brain ; Diagnosis ; Facial Bones ; Female ; Frontal Bone ; Frontal Sinus ; Headache Disorders ; Humans ; Male ; Maxilla ; Nose ; Postoperative Complications ; Sex Ratio ; Surgery, Oral