Brain metastases from lung cancer is a significant cause of morbidity and mortality,whichis lack of effective treatment.Because chemotherapeutic drugs are thought to not cross the blood-brain barrier(BBB), the role of chemotherapy in the treatment of brain metastases remains controversial. For yearsradiotherapy has been the standard treatment for brain metastases.However, recent studies have confirmedthat the BBB in patients with brain metastases tumors are broken down.At the same time,researchers havefound some new methods for chemotherapeutic drugs to reach the brain metastases.Chemotherapy will play amore and more active role in the treatment of brain metastases tumors.

Objective To compare and analyze the clinical curative effect of pituitrin and oxytocin applying in laparoscopic uterine myomectomy intraoperation .Methods According to surgical hemostasis method ,68 patients with uterine fibroids were divided into pituitrin group (group A) and oxytocin group(group B).The surgery time,intr-aoperative blood loss ,the change of postoperative hemoglobin levels and the change of blood pressure before and after treatment were observed.Results In A group,the operative time was (69.8 ±18.0)min,blood loss was (68.3 ± 19.1)mL,postoperative discharge time was (15.2 ±7.8)h,preoperative and postoperative hemoglobin difference val-ue was (10.4 ±2.6) g/L,which were significantly better than those in group B [(82.8 ±17.6) min,(88.5 ± 25.6)mL,(19.4 ±5.9)h,(13.5 ±2.9)g/L],the differences were statistically significant (all P<0.05).Postopera-tive morbidity rate in group A was 5 cases,that in group B was 9 cases,the difference was not statistically significant (P>0.05).In A group,the systolic blood pressure was (152.0 ±8.5)mmHg after treatment for 15min,which was significantly higher than (132.5 ±10.2)mmHg in group B,the difference was statistically significant (P<0.05). There were no statistically significant differences in the systolic blood pressure after treatment for 30min and 45min, and the diastolic blood pressure before and after treatment (all P>0.05).Conclusion Application of pituitrin in laparoscopic surgical hemostasis for patients with uterine fibroids can effectively reduce the surgery time ,decrease the blood loss ,its surgical hemostasis effect is better than oxytocin ,which is worth further clinical application .

OBJECTIVE: To evaluate the economic effects of different therapeutic schemes for knee osteoarthritis.METHODS: The clinical data of 116 patients with knee osteoarthritis were divided into three groups,namely,Group A(taking Celebrex 200 mg q.d for 28 days);Group B(Celebrex 200 mg daily orally plus topically application of Diclofenac diethylammonium);and Group C(Celebrex 200 mg daily orally plus topically application of 4 boxes of Capsacin ointment).The improvement of knee osteoarthritis was evaluated by Lysholm rating system.And a cost-effectiveness analysis was conducted.RESULTS: The costs of Group A,B,and C were 206.97 yuan,252.77 yuan and 298.53 yuan respectively;the effective rates were 61.54%,71.05% and 84.62%,respectively;the cost-effectiveness ratios were 336.32,355.76 and 352.79,respectively.The incremental cost-effectiveness ratios of Group B and C as against Group A were 481.60 and 396.71,respectively.CONCLUSION: In Group C compared Group A,the effective rate was significantly higher;and as compared with Group B,the cost for gaining each unit of effectiveness in Group C was significantly lower.Group C is the optimal one among the three schemes.

Child ; Hematuria ; diagnosis ; Humans

It has been shown that two pathways of signal transduction are activated under the stimulation of cytokines , such as IL-1?TNF-? ?EGF?TGF-? ?PDGF?IGF-1, secreted by fibroblast-like synoviocytes with rheumatoid arthritis. They are receptor tyrosine kinases-Ras-MAPK pathway and non- receptor tyrosine kinases-JAK-STAT pathway. The former activation plays an important role in chronic synovitis of rheumatoid arthritis. More researches are expected to focus on G-protein-AC-cAMP signal transduction pathway and the internal relations of all kinds of pathways.

Objective To study the effect of small interfering RNA(siRNA) of human papillomavirus(HPV) 18(E6) gene on apoptosis of HPV-related cervical HeLa cell line.Methods siRNA targeting HPV18 E6 mRNA was designed and generated by PCR amplification.The PCR products containing U6 promoter and the siRNA sequence were then transfected into HeLa cells via Lipofectamine()~(TM)2000.Cell viability was determined by MTT assay.Apoptosis was detected by morphological observation and flow cytometry analysis.The expression level of HPV18 E6 mRNA was assayed by RT-PCR.Results The cell growth and viability of(siRNA) transfected group were significantly inhibited(P

Objective To explore the effect of sublingual immunotherapy (S-LIT) on the balance of Th17/Treg in children with mite allergic asthma. Methods All 124 cases with mite allergic asthma were randomly divided into two groups, the control group (62 cases) was treated with ladder type inhalation, and the treatment group (62 cases) was administered of dust mite drops on the basis of conventional treatment. The peripheral frequency of Th17 cell and Treg cell of all the subjects (before and after treatment) were detected by flow cytometry, the serum cytokine IL-10、IL-17 levels wer analyzed by ELISA. Results After 1 year treatment, the Th17 cells in treatment group (1.50 %±0.87 %) was significantly lower than that before treatment (3.39 % ± 1.58 %), and less than that of the control group after 1 year of treatment (2.42 %±1.32 %) (P <0.01);after 1 year treatment, the proportion of Treg cells in treatment group (4.05 %±1.36 %) was significantly higher than that before treatment (2.33 ± 0.81%), and more than that of the control group after 1 year of treatment (2.87 %± 0.87 %) (P <0.01). After 1 year treatment, the serum IL-10 levels in treatment group (64.76±27.79 pg/mL) was significantly higher than that before treatment (36.32 ± 11.53 pg/mL), and more than that of the control group after 1 years of treatment (50.32 ± 10.97 pg/mL) (P <0.01);after 1 year treatment, the serum IL-17 levels in treatment group (20.45±8.35 pg/mL) was significantly lower than that before treatment (86.48 ± 28.19 pg/mL), and significantly less than that of the control group after 1 year of treatment (46.32 ± 12.43 pg/mL) (P <0.01). After 1 year treatment, the Childhood Asthma Control Test (C-ACT)score in the treatment group (24.35 ± 8.47) was significantly higher than the control group (20.13 ± 6.86) (P <0.05). Conclusions SLIT can decrease airway inflammation and correct the imbalance of Th17/Treg in children with mite, allergic asthma.

ObjectiveTo study streptococcus pneumonia capsular polysaccharide antibodies of patients with chronic obstructive pulmonary disease(COPD) in acute exacerbation and the feasibility of vaccination for patients with COPD.MethodsThe COPD in acute exacerbation without respiratory failure (RF)(COPD without RF group),COPD in acute exacerbation with RF (COPD with RF group),asthma (asthma group),healthy elderly examination(elderly examination group) and healthy youth examination (youth examination group) were selected,and each group had 15 cases.The levels of streptococcus pneumonia capsular polysaccharide antibodies IgG,IgM and IgA were measured in all groups.Results There was no significant difference in IgG among the five groups (P ＞ 0.05 ).The levels of IgM in COPD without RF group and elderly examination group were significantly lower than those in COPD with RF group,asthma group and youth examination group (0.554 ± 0.309 and 0.538 ± 0.327 vs.0.810 ± 0.387,0.887 ± 0.278 and 0.852 ± 0.305,P ＜ 0.05 ).Although the level of IgA in COPD without RF group was significantly lower than that in youth examination group(0.532 ±0.297 vs.0.930 ±0.502,P ＜0.05),there was no significant difference among the five groups.Conclusion Patients with COPD should inoculate pneumococcal vaccination.

Objective To study the characteristics of serum lipid metabolism in cadres aged 90 and above.Methods A total of 105 in-patient cadres aged 90 and above were assigned to the longevity group,and another 85 in-patient cadres aged 60 to 80 years were used as controls.Medical history of the participants were retrospectively reviewed,and serum levels of total cholesterol(TC),triglyceride(TG),low-density lipoprotein cholesterol(LDL-C),high-density lipoprotein cholesterol(HDL-C),apoB,apoA-I,Lp(a)and body mass index(BMI)were tested.Results Compared with the control group,TC,TG,LDL-C,apoB and non-HDL-C were significantly decreased in the longevity group[3.90 +0.89 vs 4.36 ± 1.06,0.89(0.57)vs 1.16(0.69),2.35 ±0.72 vs 2.70 ±0.88,0.68 ±0.19 vs 0.75 ±0.22,2.69 ±0.79 vs 3.18 ± 1.00,respectively].However,HDL-C/TC and HDL-C/LDL-C were significantly increased in the longevity group [0.32 ±0.084 vs 0.28 ±0.082,0.52(0.22)vs 0.43(0.28),respectively].Lp(a)of the longevity group was higher than that of the control group,although no statistically significant difference was found.BMI of the longevity group was significantly lower than that of the control group.In the longevity group,the percentage of individual who were combined with hypertension,hyperglycemia,hyperlipidemia and overweight/fat was lower (24.8％ vs 43.5％).Conclusions Serum lipid level is relatively lower in cadres aged 90 and above,and those who are combined with hypertension,hyperglycemia,hyperlipidemia and overweight/fat are significantly lower in this populations.

Objective To assess the psychometric properties of the Chinese version of Family Man-agement Measure (FaMM). Methods FaMM was translated into Chinese and distributed to 330 caregivers whose children had chronic diseases to fill the questionnaire. Results Cronhach's alpha coefficient for the subscales ranged from 0.52 to 0.86, indicating acceptable internal consistency. The content validity index was 0.84. Construct validity was supported by significant correlation between FaMM and FAD and CBCL,Pearson correlation coefficient ranged from 0.11 to 0.38. The relationship among them accorded with the expected trends of Family Management Style Framework. The result of factor analysis indicated 9 factors explaining 60.08% variance. Conclusions The psychometric property of the Chinese version of FaMM was acceptable and it could be regarded as a reliable and valid instrument to measure the family response of Chinese families whose children had chronic diseases.