Objective:To explore the application effect of action-oriented education combined with Orem nursing system in patients with permanent colostomy after rectal cancer surgery.Methods:Using the convenient sampling method, a total of 120 patients with permanent colostomy after rectal cancer surgery who were admitted to Jiaozuo People's Hospital were selected as the research objects from June 2019 to June 2020. They were randomly divided into the intervention group and the control group, with 60 cases in each group. The patients in the control group received routine care and implemented action-oriented education, while patients in the intervention group were given Orem nursing system for intervention on this basis. The self-efficacy sense after the intervention and the degree of ostomy-related knowledge before and after the intervention were compared between the two groups.Results:There was significant difference in stoma related knowledge between the two groups before and after intervention ( P<0.01) . After the intervention, patients in the intervention group had better understanding of stoma-related knowledge and self-efficacy than the control group, and the differences were statistically significant ( P<0.01) . Conclusions:The implementation of action-oriented education and Orem nursing system for patients with permanent colostomy after rectal cancer surgery can improve patients' understanding of stoma-related knowledge and self-efficacy.