Objective To observe and analyze the clinical effect of Milrinone injection in the treatment of hypertensive heart disease complicated with heart failure .Methods From February 2016 to January 2017,80 patients with hypertensive heart disease complicated with heart failure in Cilin Hospital were selected and randomly divided into observation group and control group according to the digital table ,with 40 cases in each group.The control group was given conventional therapy ,including antihypertensive therapy and the treatment of heart failure and so on .The observation group was treated with Milrinone injection on the basis of the control group .The clinical manifestations of the two groups were compared and analyzed .Results The cardiac function indicators ,B－type natriuretic peptide (BNP) and 6MWD in the observation group were better than those in the control group after treatment [observation group: HR (59.31 ±2.03) times/min,LVEF (55.98 ±5.31)%,LVEDd (54.37 ±0.83) mm,SBP (119.53 ± 7.04)mmHg,DBP(67.31 ±2.94) mmHg,BNP (198.32 ±21.54) ng/L,6MWD (332.61 ±52.70) m; control group: HR (67.63 ±2.95)min,LVEF (40.51 ±4.96)%,LVEDd (60.55 ±1.47)mm,SBP (128.47 ±8.35)mmHg,DBP (76.37 ±3.75)mmHg,BNP (227.43 ±25.96)ng/L,6MWD (254.78 ±26.16)m],the differences were statistically significant (t＝14.6943,13.4651,23.1532,5.1769,12.0250,20.5215,8.3663,all P＜0.05).The incidence rate of adverse reactions of the observation group (7.5%) was lower than that of the control group (10.0%),the differ－ence was not statistically significant (χ2＝0.156,P＜0.05).Conclusion Milrinone injection in the treatment of hypertensive heart disease has good effect , can obviously decrease BNP concentration , increase the patients'life quality,and with no obvious adverse conditions .