1.Tracheobronchial Polyps Following Thermal Inhalation Injury.
Beomsu SHIN ; Mikyeong KIM ; Hongseok YOO ; Se Jin KIM ; Ji Eun LEE ; Kyeongman JEON
Tuberculosis and Respiratory Diseases 2014;76(5):237-239
The early pulmonary consequences of inhalation injury are well documented; however, little is known about delayed pulmonary complications following thermal inhalation injury. Although thermal injury below the vocal cords is rare because of effective heat dissipation in the upper airway, inflammatory endobronchial polyps have previously been reported as a delayed complication associated with inhalation injury. We report an extraordinary case of tracheobronchial polyps in patients with smoke inhalation injury. This report shows the delayed development and natural course of tracheobronchial polyps following thermal injury.
Bronchi
;
Burns, Inhalation
;
Hot Temperature
;
Humans
;
Inhalation*
;
Polyps*
;
Smoke Inhalation Injury
;
Trachea
;
Vocal Cords
2.Exploratory Clinical Trial of a Depression Diagnostic Software That Integrates Stress Biomarkers and Composite Psychometrics
Sooah JANG ; In-Young KIM ; Sun-Woo CHOI ; Anna LEE ; Ju-Yeal LEE ; Hyunkyung SHIN ; Junwoo LEE ; Mikyeong LEE ; Kyoung-Ryul LEE ; Saeeun JUNG ; Jin Sun RYU ; Jihee OH ; Manjae KWON ; Joohan KIM ; Ryunsup AHN ; Young-Chul JUNG ; Jeong-Ho SEOK
Psychiatry Investigation 2024;21(3):230-241
Objective:
This study evaluated the clinical effectiveness of Minds.NAVI, a depression screening kit combining psychometric measures and stress hormone biomarkers, in a prospective clinical trial. The objective was to assess its potential as a depression screening tool and investigate the associations between psychological assessments, salivary hormone staging, and depression severity.
Methods:
Thirty-five participants with major depressive disorder and 12 healthy controls (HCs) were included. The Minds.NAVI software, utilizing the PROtective and Vulnerable factors battEry Test (PROVE) and salivary cortisol/dehydroepiandrosterone (DHEA) analysis, was employed. The PROVE test is a comprehensive self-report questionnaire that assesses depressive symptoms, suicide risk, attachment style, adverse childhood experiences, mentalization capacity, and resilience. In addition, salivary cortisol and DHEA levels were measured to evaluate the functional stage of the hypothalamic–pituitary–adrenal (HPA) axis.
Results:
Minds.NAVI exhibited 100% sensitivity, 91.7% specificity, and 97.9% accuracy in distinguishing depression from HCs within an exploratory small group. Salivary stress hormone phases showed changes with depression stage (p=0.030), and the proportion of patients with “adrenal exhaustion stage” was higher in the moderate/severe depression group (p=0.038). Protective/vulnerable factors differed significantly between controls and depressed groups (p<0.001). Cortisol awakening response inversely correlated with depressive symptom severity (r=-0.31, p=0.034).
Conclusion
This study suggested possible clinical effectiveness of Minds.NAVI, a depression screening tool that integrates psychometric measures and stress hormone biomarkers. The findings support the potential association between depression, chronic stress, and HPA axis hyporesponsiveness.