Pregnancy-associated gastric cancer is extremely rare. In many cases, it is diagnosed at an advanced stage because the symptoms during pregnancy are generally overlooked. We report three cases of gastric cancer during pregnancy with various outcomes. The first case included a patient with stage IV gastric cancer who received palliative chemotherapy. This patient had a preterm birth and died 7 months after diagnosis. The second case received neoadjuvant chemotherapy during pregnancy and a total gastrectomy was performed after delivery. She then received adjuvant chemoradiotherapy. This patient developed pulmonary metastasis and died of recurrence 41 months after surgery. In the third case, a distal subtotal gastrectomy was performed at week 14 of pregnancy, with no complications. The patient received adjuvant chemoradiotherapy. She is currently without recurrence 14 months after surgery. In patients with pregnancy-associated gastric cancer, treatment decisions are predominantly influenced by clinical stage and gestational age at diagnosis.
Carcinoma, Signet Ring Cell ; Chemoradiotherapy, Adjuvant ; Diagnosis ; Drug Therapy ; Gastrectomy ; Gestational Age ; Humans ; Neoplasm Metastasis ; Pregnancy* ; Premature Birth ; Recurrence ; Stomach Neoplasms*

Development of Internal Carotid Artery pseudoaneurysms (ICAp) after transsphenoidal surgery is extremely rare, occurring only in 0.4% of cases. Surgical treatment of ICAp poses a real challenge to the neurosurgeon as treatment may require parent vessel sacrifice or artery reconstruction with bypass grafting. Furthermore, surgical resolution of these lesions is rarely reported in the literature.The internal carotid artery is prone to iatrogenic injury in transsphenoidal surgery due to its frequent involvement in pituitary adenomas. Intracranial pseudoaneurysms may be at high risk for rupture and increased morbidity and mortality. Here we present a case of a patient with an ICAp rupture two months after transsphenoidal surgery for a pituitary adenoma.

A protocol of polymerase chain reaction-random amplified polymorphic DNAs (PCR-RAPDs) was established to analyse the gene diversity and genotype identification for clones of Sequoia sempervirens (D. Don) Endl. in Chile. Ten (out of 34) clones from introduction trial located in Voipir-Villarrica, Chile, were studied. The PCR-RAPDs technique and a modified hexadecyltrimethylammonium bromide (CTAB) protocol were used for genomic DNA extraction. The PCR tests were carried out employing 10-mer random primers. The amplification products were detected by electrophoresis in agarose gels. Forty nine polymorphic bands were obtained with the selected primers (BG04, BF07, BF12, BF13, and BF14) and were ordered according to their molecular size. The genetic similarity between samples was calculated by the Jaccard index and a dendrogram was constructed using a cluster analysis of unweighted pair group method using arithmetic averages (UPGMA). Of the primers tested, 5 (out of 60) RAPD primers were selected for their reproducibility and high polymorphism. A total of 49 polymorphic RAPD bands were detected out of 252 bands. The genetic similarity analysis demonstrates an extensive genetic variability between the tested clones and the dendrogram depicts the genetic relationships among the clones, suggesting a geographic relationship. The results indicate that the RAPD markers permitted the identification of the assayed clones, although they are derived from the same geographic origin.
Genotype ; Polymerase Chain Reaction ; methods ; Random Amplified Polymorphic DNA Technique ; methods ; Sequoia ; classification ; genetics

Objectives: This study aimed to investigate sleep patterns and chronotypes in Spanish women diagnosed with fibromyalgia syndrome (FMS). Methods: A descriptive, cross-sectional observational study following the Strengthening the Reporting of Observational Studies in Epidemiology guidelines was conducted from March 1, 2024, to June 10, 2024, at the Fibromyalgia and Chronic Fatigue Syndrome Association of Tenerife (San Cristóbal de La Laguna, Spain). Results: A total of 73 women, with a mean age of 56.15±6.47 years, diagnosed with FMS were enrolled. Bedtime habits and wake-up times showed significant variability, reflecting individual differences in sleep chronotype preferences among the participants. The Pittsburgh Sleep Quality Index revealed a mean score of 11.62±0.92, indicating substantial challenges in sleep quality among participants with FMS. Sleep efficiency was low, averaging 14.86%±0.34%, and there was a significant discrepancy in sleep duration between workdays and free days, with an average difference of 2.0±0.5 h. The participants reported compensatory sleep through an average of two naps per day, each lasting 40 min. Conclusions Participants with FMS experienced poor sleep quality, characterized by variability in sleep patterns between workdays and free days, along with significant social jet lag. Low sleep efficiency suggests a prevalent sleep debt, which the participants attempted to mitigate through frequent and extended napping.

Objectives: This study aimed to investigate sleep patterns and chronotypes in Spanish women diagnosed with fibromyalgia syndrome (FMS). Methods: A descriptive, cross-sectional observational study following the Strengthening the Reporting of Observational Studies in Epidemiology guidelines was conducted from March 1, 2024, to June 10, 2024, at the Fibromyalgia and Chronic Fatigue Syndrome Association of Tenerife (San Cristóbal de La Laguna, Spain). Results: A total of 73 women, with a mean age of 56.15±6.47 years, diagnosed with FMS were enrolled. Bedtime habits and wake-up times showed significant variability, reflecting individual differences in sleep chronotype preferences among the participants. The Pittsburgh Sleep Quality Index revealed a mean score of 11.62±0.92, indicating substantial challenges in sleep quality among participants with FMS. Sleep efficiency was low, averaging 14.86%±0.34%, and there was a significant discrepancy in sleep duration between workdays and free days, with an average difference of 2.0±0.5 h. The participants reported compensatory sleep through an average of two naps per day, each lasting 40 min. Conclusions Participants with FMS experienced poor sleep quality, characterized by variability in sleep patterns between workdays and free days, along with significant social jet lag. Low sleep efficiency suggests a prevalent sleep debt, which the participants attempted to mitigate through frequent and extended napping.

Objectives: This study aimed to investigate sleep patterns and chronotypes in Spanish women diagnosed with fibromyalgia syndrome (FMS). Methods: A descriptive, cross-sectional observational study following the Strengthening the Reporting of Observational Studies in Epidemiology guidelines was conducted from March 1, 2024, to June 10, 2024, at the Fibromyalgia and Chronic Fatigue Syndrome Association of Tenerife (San Cristóbal de La Laguna, Spain). Results: A total of 73 women, with a mean age of 56.15±6.47 years, diagnosed with FMS were enrolled. Bedtime habits and wake-up times showed significant variability, reflecting individual differences in sleep chronotype preferences among the participants. The Pittsburgh Sleep Quality Index revealed a mean score of 11.62±0.92, indicating substantial challenges in sleep quality among participants with FMS. Sleep efficiency was low, averaging 14.86%±0.34%, and there was a significant discrepancy in sleep duration between workdays and free days, with an average difference of 2.0±0.5 h. The participants reported compensatory sleep through an average of two naps per day, each lasting 40 min. Conclusions Participants with FMS experienced poor sleep quality, characterized by variability in sleep patterns between workdays and free days, along with significant social jet lag. Low sleep efficiency suggests a prevalent sleep debt, which the participants attempted to mitigate through frequent and extended napping.