Humans ; Lung Neoplasms ; therapy ; Microwaves ; therapeutic use ; Treatment Outcome

We report a case of functional parathyroid cyst treated by ultrasound-guided anhydrous ethanol sclerotherapy and microwave ablation. The 63-year-old female patient was diagnosed to have functional parathyroid cyst with hypercalcemia, high PTH and cystic space-occupying lesions in the neck by ultrasound, radionuclide scanning and PTH measurement of the cystic fluid. The patient refused to receive cyst resection, and anhydrous ethanol sclerotherapy with microwave ablation was performed under ultrasound guidance. The procedure was completed smoothly without any complications either during or after the operation. Follow-up examination of the patient at 18 months after the operation showed a significant reduction of the mass and normal blood calcium and iPTH levels, demonstrating a clinical cure of the patient. Ablative treatment of functional parathyroid cyst has not been documented so far. This approach provides a minimally invasive treatment modality for such cases where surgical resection is not an option, but its efficacy and safety need to be evaluated in more cases with longer follow-up time.
Female ; Humans ; Middle Aged ; Microwaves/therapeutic use* ; Plastic Surgery Procedures ; Cysts ; Ethanol/therapeutic use* ; Ultrasonography, Interventional

OBJECTIVETo observe the millimeter wave therapy responses in patients with burning mouth syndrome.

METHODSEighty patients were randomized divided into 4 groups. The first group was treated with both millimeter wave irradiation and routine medication, the second group with millimeter wave irradiation, the third with pretending millimeter wave irradiation and routine medication and the fourth with routine medication. Pain, extravasated blood level and autonomic nerve system condition were double-blindly evaluated either before or after the treatment.

RESULTSStatistically significant difference (P < 0.05) was found as the degree of pain was compared before and after treatment of all the 4 groups. The first and second group, which were affected by the millimeter wave irradiation, had obvious improvements in the extravasated blood level and autonomic nerve system condition (P < 0.05). When the 4 groups were compared with each other, there were significant differences (P < 0.05) between the first and the fourth groups, and the second and the fourth groups regarding the reduction of pain. According to extravasated blood level, significant differences (P < 0.05) were found in the first and third or fourth groups, the second and third or fourth groups.

CONCLUSIONSThe irradiation of holographic point by millimeter wave can improve the patients' pain, extravasated blood level and autonomic nerve system condition. It might provide a new treatment method for burning mouth syndrome.

Acupuncture Points ; Burning Mouth Syndrome ; therapy ; Humans ; Microwaves ; therapeutic use ; Treatment Outcome

OBJECTIVETo investigate the effect of transrectal ultrasound-guided microwave ablation of canine prostate tissue.

METHODSGuided by transrectal ultrasound, we conducted microwave ablation on each side of the prostate in 12 male dogs, 6 at 40 W/ 120 s (group A) and the other 6 at 40 W/160 s (group B), and observed the changes in the thermal lesions using grayscale ultrasound. After thermal ablation, we measured the volume of the thermal lesions by contrast-enhanced ultrasound (CEUS). Then we harvested the whole prostate from the animals and determined the lesion volumes in the fresh tissue specimens.

RESULTSGrayscale ultrasound revealed an echogenic area at the initiation of the microwave ablation procedure, which was enlarged with the increase of ablation time. At the end of the procedure, the lesions appeared as an irregular heterogeneous echogenic area. CEUS showed oval non-perfused areas, which appeared as well-defined non-echoic areas in sharp contrast with the surrounding normal prostate parenchyma with bolus injection of contrast material (Sonovue, 2.4 ml), and that the thermal lesion volumes of groups A and B were (1.18 +/- 0.23) cm3 and (1.52 +/- 0.23) cm3, respectively. The thermal lesions of the gross specimen exhibited an elliptical shape, pale color and clear margin, and their volumes were (1.13 +/- 0.20) cm3 and (1.48 +/- 0.20) cm3, respectively, in groups A and B.

CONCLUSIONDifferent combinations of time and power can produce coagulative necrotic lesions of different volumes in the local prostatic tissue. CEUS can accurately manifest the lesion area and thus avoid excessive or inadequate ablation treatment.

Animals ; Catheter Ablation ; methods ; Dogs ; Male ; Microwaves ; therapeutic use ; Prostate ; diagnostic imaging ; Ultrasonography

OBJECTIVEA 2.45 GHz microstrip applicator using single rectangle sheet structure is presented.

METHODSBased on the radiant principle of microstrip antenna, the applicator's parameter is designed and the simulating model is set and optimized in HFSS.

RESULTSMeasured by network analyzer, the technical target of this applicator is complied with design demand. During irradiation experiment, based on 30 W power, 30 mm radiation distance and 15 min duration experiment condition, the thermal field distribution map of phantom is obtained from the far-infrared image instrument. The 3D map shows that the region of thermal field centre has small radius and deep heat penetration.

CONCLUSIONThe microwave energy from this applicator can reach the tumor in superficial layer without heat injuring normal tissue around it.

Equipment Design ; Hyperthermia, Induced ; instrumentation ; methods ; Microwaves ; therapeutic use ; Neoplasms ; therapy

A new microwave applicator for intracavitary hyperthermia treatment of uterocervical cancer has been designed and tested. Compared with the traditional microwave applicators, the exposed inner conductor of this applicator is replaced by a cone-helical antenna with the reflect shade. We confirm that the heat pattern of the applicator is shifted towards the tip in muscle tissue equivalent phantom material. The result indicates that this new applicator may play an important role in clinical use for treatment.
Equipment Design ; Female ; Humans ; Hyperthermia, Induced ; instrumentation ; Microwaves ; therapeutic use ; Uterine Cervical Neoplasms ; therapy

The paper introduces four kinds of 2450 MHz antennas including noninsulted (bare), insulated-open-tip (I.O.T.), dipole-type and sleeve invasive microwave ones. The comparison between the antennas' hyperthermia performances in the muscle tissue phantom made by specific absorption rate (SAR) shows that the sleeve antenna is the best. It has a bigger heating range and a changeless shape and is independent of the inserting depth.
Equipment Design ; Evaluation Studies as Topic ; Humans ; Hyperthermia, Induced ; instrumentation ; Microwaves ; therapeutic use ; Models, Biological ; Temperature

This paper describes a new method of temperature measurement in microwave field. This method resolves a series of problems such as the microwave field suppression, the linearization of the temperature sensor and the sensor exchangeability.
Electricity ; Equipment Design ; Humans ; Hyperthermia, Induced ; instrumentation ; methods ; Linear Models ; Microwaves ; therapeutic use ; Neoplasms ; therapy

The basic objective of microwave hyperthermia is to raise the temperature in the tumor tissue without overheating point for a long time. It's difficult to achieve uniform temperature distribution using the continuous heating without changing the antenna shape and inserting position. In this paper, the interstitial antenna worked in the frequency of 2450 MHz inserted into an infinite muscle model is studied. The Finite Difference Time Domoin (FDTD) method was used to calculate the electromagnetic field, while the finite difference method (FDM) was used to analyze the temperature distribution in tumor tissue. The simulation results show that the long-time evenly heating can be achieved by using the alternately heating process and the treatment area can be changed by adjusting input power.
Electromagnetic Phenomena ; Humans ; Hyperthermia, Induced ; instrumentation ; Microwaves ; therapeutic use ; Neoplasms ; therapy ; Temperature

OBJECTIVE: To explore the risk grading method for benign thyroid nodules before microwave ablation and the clinical significance of risk grading. METHODS: This study was conducted among 527 patients undergoing ultrasound-guided microwave ablation of benign thyroid nodules between July, 2017 and December, 2020.Based on anatomic relationship of the thyroid nodules with the adjacent tissues, the ablation risk was classified into 4 levels: low, medium, high and extremely high risks.The incidence of severe complications and the rate of residual nodules following the ablation were recorded. RESULTS: In the patients graded to have low, medium, high and extremely high preoperative risks, the incidences of severe complications following the ablation were 0%, 0.88%, 2.41% and 6.78%, respectively, showing no significant differences among the different risk groups (P > 0.05).The rates of postoperative residual nodules in the 4 risk groups were 1.59%, 6.14%, 14.43% and 71.19%, respectively, showing a significant difference between the low and medium risk groups and the high and extremely high risk groups (P < 0.001). CONCLUSION Preoperative risk grading for thyroid nodular ablation can be helpful for prevention of severe complications during ablation and prediction of residual nodules after ablation.
Humans ; Thyroid Nodule/epidemiology* ; Microwaves/therapeutic use* ; Catheter Ablation/methods* ; Treatment Outcome ; Retrospective Studies