1.Advances in the research of microRNA in Orchidaceae.
Zihan XU ; Yue CHEN ; Fengrong HU
Chinese Journal of Biotechnology 2022;38(1):66-76
As a class of small non-coding RNAs, microRNA (miRNA) is widely present and plays important regulatory roles in plant growth, development and stress response. Based on the mechanism of miRNAs in plants, we review the identification of miRNAs in some genera of Orchidaceae, the specific functions of several miRNAs and other relevant studies on miRNAs in the last decade, in order to provide a reference for better understanding function and regulatory network of small RNAs in orchids.
MicroRNAs/genetics*
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Orchidaceae/genetics*
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Plants/genetics*
2.MicroRNA and multiple myeloma.
Chun-Ming LI ; Li-Juan CHEN ; Jian-Yong LI
Journal of Experimental Hematology 2011;19(1):244-248
MicroRNA (miRNA) represents a new class of endogenous, non-coding small RNA molecules that functions as gene regulator. They can repress the expression of target genes at the post-transcriptional level by base pairing to the 3'-untranslated region of the respective target mRNAs. miRNA plays important roles in the regulation of cell proliferation, metabolism, apoptosis and differentiation. The dysregulation of miRNA expression contributes to tumorigenesis. This review summarizes recent progress of research on the characteristics and function of miRNA, as well as the role of miRNA in multiple myeloma development, abnormal karyotype in chromosomes and drug-resistant.
Humans
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MicroRNAs
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Multiple Myeloma
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genetics
4.Progress of study on circulating microRNAs in hematologic malignancies.
Ying QU ; Hai-Yan HE ; Jian HOU
Journal of Experimental Hematology 2014;22(1):219-222
MicroRNAs (miRNAs) are a class of endogenous small non-coding RNAs that play an important role in the pathogenesis and progression of tumor. Recently, it is discovered that circulating microRNA exist stably in body fluids, such as serum/plasma, cerebrospinal fluid, saliva, urine, breast milk and so on. Circulating microRNA profiles now have been associated with different hematologic malignancy types, disease states and prognosis. They may serve as a new class of non-invasive diagnostic or prognostic biomarkers, and even the potential therapeutic targets in hematologic malignancies. In this article, the circulating miRNA, existent pattern and function of circulating miRNA, and circulating miRNA and hematologic malignancies are reviewed.
Hematologic Neoplasms
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genetics
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Humans
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MicroRNAs
6.A new miRNA story about tumor metastasis.
Chinese Journal of Biotechnology 2012;28(2):131-133
Humans
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MicroRNAs
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genetics
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metabolism
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Neoplasm Metastasis
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genetics
8.MicroRNA and lung cancer.
Chinese Journal of Lung Cancer 2010;13(4):380-385
Humans
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Lung Neoplasms
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genetics
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MicroRNAs
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genetics
9.Advances in the research of the role of MicroRNAs in wound healing.
Chinese Journal of Burns 2013;29(4):374-377
MicroRNAs are endogenous noncoding RNA molecules with 19-22 nucleotides in length. MicroRNAs can post-transcriptionally regulate gene and (or) protein expression by binding to their target messenger RNAs (mRNAs), leading to mRNA degradation or suppression of translation. As a huge family that regulates gene expression, microRNAs has recently been shown to not only participate in the normal healing processes of wounds but also closely related to pathologic wound healing, and formation of hypertrophic scars and keloids. This review focuses on the biogenesis of microRNA and its role in wound healing.
Animals
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Humans
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MicroRNAs
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Wound Healing
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genetics
10.Advance of studies on microRNA and myelodysplastic syndrome.
Journal of Experimental Hematology 2011;19(4):1079-1082
MicroRNA (miRNA), evolutionarily conserved, endogenous, small, noncoding RNA molecule of about 22 nucleotides in length, have been recently attributed a crucial role in numerous physiological and pathological processes including the regulation of cellular development, differentiation, proliferation, apoptosis and oncogenesis. Myelodysplastic syndrome (MDS) is a heterogeneous group of clonal hematologic disorders characterized clinically and morphologically by ineffective hematopoiesis and increased risk of leukaemic transformation. The role of miRNA abnormal expression in pathogenesis and prognosis of MDS is reviewed in this article, including miRNA related with pathogenesis, miRNA related with prognosis of MDS and so on.
Hematopoiesis
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Humans
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MicroRNAs
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Myelodysplastic Syndromes
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genetics
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pathology