1.Factors Related to the Relapse of First-episode Schizophrenia
Yajuan NIU ; Chengjing WU ; Phillips MICHAEL
Chinese Mental Health Journal 1989;0(03):-
0.05). Conclusion: DUP related to short-term prognosis of first-episode schizophrenia patients, the DUP is shorter, the prognosis is better, DUP was related factor of relapse.
2.Factor Analysis of Nurses Observation Scale for Inpatinent Evalu ation
Feifei LI ; Philips MICHAEL ; Zhongfu JI ; Qiling WU ; Jing WAN
Chinese Journal of Clinical Psychology 2001;9(1):17-20
Objective: To improve clinical utility of the Nurses Observation Sca le for Inpatient Evaluation (NOSIE-30) in China. Methods: Based on the original scale, which only provides names and ranked scores for items, we developed clear definitions for each item and anchoring descriptions for score rating. 164 firs t-episode schizophrenic patients were evaluated with this scale every two weeks after admission. A total of 994 evaluations were completed. The collected data w ere randomly divided into two independent data sets. The number and content of t he subscales were revised based on principal component factor analysis and item analysis of the first data set. The revised scale was then evaluated and compare d with the original 7-subscale version of the instrument using the second data s et. Results: Factor analysis found that the factor structu re of the revised scal e was markedly different from that of the original instrument. Item analysis res ulted in elimination of 30 original items and redistribution of the remaining 26 items into 5 subscales. Comparison of the revised scale with the original instr ument revealed better psychometric properties for the former than the latter.Conclusion: The subscale scores of the original 7-subscale v ersion of NOSIE-30 did not reflect independent symptom clusters in Chinese schizophrenic inpatients. T o improve the usefulness of the scale in China, the present study recommended a better revised scale with re-definition of items into 5 subscales.
3.Sex/gender and additional equity characteristics of providers and patients in perioperative anesthesia trials: a cross-sectional analysis of the literature
Nicole ETHERINGTON ; Michael WU ; Sylvain BOET
Korean Journal of Anesthesiology 2021;74(1):6-14
Sex and gender, among other equity-related characteristics, influence the process of care and patients’ outcomes. Currently, the extent to which these characteristics are considered in the anesthesia literature remains unknown. This study assesses their incorporation in randomized controlled trials (RCTs) on anesthesia-related interventions, for both patients and healthcare providers. This is a cross-sectional analysis using an existing dataset derived from the anesthesia literature. The dataset originated from a scoping review searching MEDLINE, Embase, CINAHL, CENTRAL, and the Cochrane Database of Systematic reviews. RCTs investigating the effect of anesthesia-related interventions on mortality for adults undergoing surgery were included. Equity outcome measures were recorded for both patients and providers and assessed for inclusion in the study design, reporting of results, and analysis of intervention effects. Three-hundred sixty-one RCTs (n = 144,674) were included. Most RCTs (91%) reported patient sex/gender, with 58% of patients identified as male. There were 139 studies (39%), where 70% or more of the sample was male, compared to just 14 studies (4%), where 70% or more of the sample was female. Only 10 studies (3%) analyzed results by patient sex/gender, with one reporting a significant effect. There was substantial variation in how age was reported, although nearly all studies (98%) reported some measure of age. For healthcare providers, equity-related information was never available. Better consideration of sex/gender and additional health equity parameters for both patients and providers in RCTs is needed to improve evidence quality, and ultimately, patient care and outcome.
6.Chinese Public Attitudes Toward Epilepsy (PATE) scale: translation and psychometric evaluation
Kheng Seang Lim ; Wan Yuen Choo ; Cathie Wu ; Michael D Hills ; Chong Tin Tan
Neurology Asia 2013;18(3):261-270
Introduction: None of the quantitative scale for public attitudes toward epilepsy was translated to Chinese
language. This study aimed to translate and test the validity and reliability of a Chinese version of the
Public Attitudes Toward Epilepsy (PATE) scale. Methods: The translation was performed according to
standard principles and tested in 140 Chinese-speaking adults aged more than 18 years for psychometric
validation. Results: The items in each domain had similar standard deviations (equal item variance),
ranged from 0.85-0.95 in personal domain and 0.75-1.04 in general domain. The correlation between an
item and its domain was 0.4 and above for all, and higher than the correlation with the other domain.
Multitrait analysis showed the Chinese PATE had a similar variance, floor and ceiling effects, and
relative relationship between the domains, as the original PATE. The Chinese PATE scale showed
a similar correlation with almost all demographic variable except age. Item means were generally
clustered in the factor analysis as hypothesized. The Cronbach’s α values was within acceptable range
(0.773) in the personal domain and satisfactory range (0.693) in the general domain.
Conclusion: The Chinese PATE scale is a validated and reliable translated version in measuring the
public attitudes toward epilepsy.
7.Non-Invasive Imaging of Preoperative Mapping of Superficial Veins in Free Flap Breast Reconstruction.
Michael W CHU ; Jonathon R SARIK ; Liza C WU ; Joseph M SERLETTI ; Jonathan BANK
Archives of Plastic Surgery 2016;43(1):119-121
No abstract available.
Breast*
;
Female
;
Free Tissue Flaps*
;
Mammaplasty*
;
Veins*
8.Indoor mite allergen levels, specific IgE prevalence and IgE cross-inhibition pattern among asthmatic children in Haikou, southern China.
Yi-Wu ZHENG ; Shi CHEN ; Xu-Xin LAI ; Birgitte GJESING ; Nan-Shan ZHONG ; Michael D SPANGFORT
Chinese Medical Journal 2012;125(17):3059-3063
BACKGROUNDHaikou locates in tropical island with unique mite propagation. The aim of this stuy is to determine mite allergens levels in Haikou, and to investigate the prevalence of mite specific IgE-sensitization and IgE cross-reactivity between house dust mites.
METHODSAllergen and antigen concentrations against six mite species were tested by enzyme-linked immunosorbent assay (ELISA). Specific IgE concentrations and cross-inhibitions were measured with ADVIA Centaur(®).
RESULTSAllergen or antigen Dermatophagoides pteronyssinus (Der p 1), Blomia tropicalis (Blo t) and Tyrophagus putrescentia (Tyr p) were detected in dust samples. Dermatophagoides farinae (Der f 1), Lepidoglyphus destructor (Lep d 2), and Acarus siro (Aca s) were found in very few samples. Specific IgE tests showed high prevalence of sensitizations against all tested mites with high IgE levels to Der p, Der f, and Blo t. Storage mites, Blo t, Tyr p, Lep d, and Aca s, could inhibit Der p from 0 to 50%. Storage mites could inhibit Der f between 30% and 100%. Der p IgE could be inhibited by Der f with up to 90%, and vice versa. Der p could inhibit Blo t from 40% to 80%. Blo t was able to fully inhibit IgE binding to Lep d, Tyr p, and Aca s compared to partial inhibition by Der p.
CONCLUSIONSDer p is the dominating mite and has the highest specific IgE prevalence among asthmatic children. Blo t represents an important source of storage mite sensitization and some patients may be independently sensitized to both Der p and Blo t. High prevalence of sensitization to Der f may be due to IgE-mediated cross-reactivity with Der p and Blo t.
Adolescent ; Air Pollution, Indoor ; Allergens ; analysis ; Animals ; Antigens, Dermatophagoides ; analysis ; Arthropod Proteins ; analysis ; Asthma ; immunology ; Child ; Child, Preschool ; China ; Cross Reactions ; Cysteine Endopeptidases ; analysis ; Dust ; Humans ; Immunoglobulin E ; blood ; immunology ; Mites ; immunology
9.Association between tumor necrosis factor alpha gene polymorphism and colorectal cancer.
Guo-yang WU ; Xiao-min WANG ; Michael KEESE ; Till HASENBERG ; Jörg W STURM
Chinese Journal of Gastrointestinal Surgery 2008;11(6):569-571
OBJECTIVETo elucidate the association of TNF-alpha-308G/A gene functional polymorphism with the development and progression of colorectal cancer.
METHODSPCR-RFLP was employed to detect the TNF-alpha-308 G/A genotypes in 157 colorectal cancer patients and 117 healthy controls.
RESULTSThe frequency of TNF-alpha-308 genotype and allele were not significantly different between colorectal cancer patients and healthy controls (genotype chi(2)=1.054, P=0.591, allele chi(2)=0.404, P=0.525). The frequency of A/A genotype and A allele in III+IV stage (62 patients in total) were higher than those in I+II stages (85 patients in total) (A allele: 22.6% vs 12.9%, A/A genotype: 8.1% vs 1.2%), and the differences were significant (genotype P=0.048, OR=7.368, 95% CI=0.839-64.743, allele chi(2)=4.720, P=0.03, OR=1.962, 95% CI=1.061-3.628). The frequency of TNF-alpha-308 genotype were not significantly different among different colorectal cancer grades (chi(2)=3.009,P=0.591).
CONCLUSIONTNF-alpha-308G/A gene polymorphism is not associated with the development of colorectal cancer, but TNF-alpha-308 A/A genotype and A allele are related to the progression of colorectal cancer.
Adult ; Aged ; Aged, 80 and over ; Alleles ; Case-Control Studies ; Colorectal Neoplasms ; genetics ; pathology ; Female ; Gene Frequency ; Genetic Predisposition to Disease ; Genotype ; Humans ; Male ; Middle Aged ; Neoplasm Staging ; Polymorphism, Single Nucleotide ; Tumor Necrosis Factor-alpha ; genetics
10.Association between vascular endothelial growth factor gene 936 T/C polymorphism and colorectal cancer together with anastomotic leakage.
Guo-Yang WU ; Xiao-Min WANG ; Michael KEESE ; Till HASENBERG ; Jörg W STURM
Chinese Journal of Surgery 2006;44(21):1505-1507
OBJECTIVETo investigate the association between VEGF gene 936 T/C polymorphism and colorectal cancer together with anastomotic leakage.
METHODSPolymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) was used to detect the VEGF 936 T/C genotypes in colorectal cancer patients and healthy controls.
RESULTSThere was no significant difference in the frequency of VEGF 936 C/C genotype or C allele between colorectal cancer patients and healthy controls (P > 0.05). The C/C genotype or C allele in colorectal cancer patients with anastomotic leakage was less frequently found than in the group without anastomotic leakage (P < 0.05).
CONCLUSIONSVEGF 936 C/C genotype or C allele is not related to the development of colorectal cancer, but they can reduce the risk of anastomotic leakage after surgery in colorectal cancer patients.
Adult ; Aged ; Aged, 80 and over ; Alleles ; Colorectal Neoplasms ; genetics ; surgery ; Digestive System Fistula ; etiology ; genetics ; Endothelial Growth Factors ; genetics ; Female ; Gene Frequency ; Genotype ; Humans ; Male ; Middle Aged ; Polymerase Chain Reaction ; Polymorphism, Restriction Fragment Length ; Polymorphism, Single Nucleotide ; Postoperative Complications ; etiology ; Surgical Stomas ; adverse effects