Extramedullary pulmonary hematopoiesis is a rare entity with a limited number of case reports in the available literature only. We report the case of a 66-year-old man with known primary myelofibrosis, in whom a Technetium-99m sulfur colloid bone marrow scan with single-photon emission computed tomography (SPECT)/CT revealed a pulmonary hematopoiesis as the cause of pulmonary hypertension and severe tricuspid regurgitation. To the best of our knowledge, this is the first description of Technetium-99m sulfur colloid SPECT/CT imaging in this rare condition.
Aged ; Bone Marrow/*radionuclide imaging ; *Hematopoiesis, Extramedullary ; Humans ; Hypertension, Pulmonary/*etiology/radionuclide imaging ; Lung/*radionuclide imaging ; Male ; Primary Myelofibrosis/complications ; Technetium Tc 99m Sulfur Colloid/diagnostic use ; Tomography, Emission-Computed, Single-Photon/methods ; Tomography, X-Ray Computed ; Tricuspid Valve Insufficiency/*etiology/radionuclide imaging

A 49-year-old Chinese woman was referred to our hospital for management of multiple lung nodules, which were incidentally detected on routine chest radiography. Chest computed tomography (CT) confirmed the presence of multiple pulmonary nodules and lung cysts. The lung cysts were located apart from the pulmonary nodules. CT-guided biopsy of the pulmonary nodule specimens confirmed the diagnosis of nodular pulmonary amyloidosis. While cavitation of existing pulmonary amyloid nodules is a well-recognised feature of nodular pulmonary amyloidosis, widespread lung cysts located apart from pulmonary nodules is rare.
Amyloidosis ; diagnosis ; pathology ; Biopsy ; Cysts ; diagnosis ; Female ; Humans ; Immunohistochemistry ; Lung ; pathology ; Middle Aged ; Multiple Pulmonary Nodules ; diagnosis ; pathology ; Radiography, Thoracic ; Tomography, X-Ray Computed