Objective:To explore the methods to improve the survival rate of autologous fat transplantation in breast augmenta-tion and reduce postoperative complications.Methods:From May 2007 to May 2014,423 patients who underwent autologous fat transplantation in breast augmentation were selected .The fat extracted from different parts of body by swelling method,was purified by lipokit fat separation and centrifugation system,and then injected into breast by fan-shaped multilevel linear injec-tion.Results:Among the 423 patients who underwent autologous fat transplantation in breast augmentation,there was one case of fat liquefaction,five cases of fat mass,and one case of microcalcifications.The other patients had good results.The av-erage survival rate of autologous fat transplantation in breast augmentation was about 50 %.Conclusion:By strictly controlling the extraction,separation and purification of the fat,and applying layered,multipoint and multidemensional injection,the sur-vival rate of the autologous fat transplantation can be improved and the rate of postoperative complications can be reduced.