Medical Immunology is a core basic course for medical majors.In order to broaden students'horizons,cultivate students'scientific thinking,and improve students'problem-solving ability,we designed the"scientific problem-based discussion-situational teaching"module in Medical Immunology course.We create"scientific research situations"based on"cutting-edge topics"to allow students investigating in the laboratory just like scientific researchers.The course includes three parts:"Problem-Lecture-Dis-cussion","Teaching by Expert"and"Experiment Observation",allowing students to experience the research processes,including how to propose,analyze and solve the scientific questions.This teaching method effectively promotes students'understanding and ap-plication of theoretical knowledge,increases their team spirit,cultivates their scientific thinking,and stimulates their interests in sci-entific research.