Objective To evaluate the diagnosis significans of histopathological observation combined with tumor markers detec-tion in gastric cancer.Methods To retrospectively review the pathological data and serum levels of tumor markers of 36 gastric cancer patients(gastric cancer group)and 41 patients with benign gastric disease(gastric disease group),and to compare with tumor marker detection levels of 30 healthy people(healthy control group)and analyze the differences.Results The serum levels of tumor markers in gastric cancer group were obviously higher than those in healthy control group and gastric disease group(P <0.05).The early diagnosed rate for gastric cancer was 55.6% by histopathological observation,which increased to 91.7% when combined with tumor markers detection.And the difference was significant(P <0.05 ).Conclusion Histopathological observation combined with tumor markers detection could improve the diagnosis sensitivity and accuracy in gastric cancers.

Objective:To investigate the current status of multi-drug use in elderly inpatients with multiple chronic conditions in internal medicine and its correlation with nursing risk events, and to put forward targeted suggestions to help manage clinical multiple drug use in elderly patients.Methods:Using the convenient sampling method, a total of 2 254 elderly inpatients in Department of Internal Medicine in 4 Class Ⅲ Grade A general hospitals in Sichuan province were selected to conduct a questionnaire survey from March 2020 to January 2021, and their general conditions, multiple chronic conditions and multiple drug use were analyzed. Single factor and binary Logistic regression were used to analyze the current situation of multiple drug use in elderly patients with chronic disease and its influence on nursing risk events.Results:There were statistically significant differences in patients with different ages, weights, education levels, personal income, medical payment methods, whether they were weak or not, and whether patients with multiple chronic conditions took multiple drugs ( P<0.05) . Logistic regression analysis showed that education level and the number of chronic diseases were independent risk factors for multiple drug use ( P<0.05) . There were statistically significant differences in the total number of nursing risk events and the occurrence of pressure injuries, deep vein thrombosis and cardiac arrest in patients with multiple medications ( P<0.05) . In the same state of multimorbidity, the nursing risk events of patients with multiple drug use increased. In patients with the same multiple medications, the incidence of patient nursing risk events with an increase in the number of multimorbidities showed a downward trend. Conclusions:Elderly patients with a high education level, a large number of chronic diseases and aged 65-74 years old should pay special attention to whether they have multiple drug use behaviors. In the future, it is necessary to actively popularize the knowledge of rational drug use, actively prevent the occurrence of chronic diseases, strengthen the cooperation of drug management teams and comprehensively consider treatment options in multiple specialties, so as to fundamentally reduce multiple drug use.