Objective To synthetically evaluate medical treatment outcomes of two operative methods on benign prostatic hyperplasia (BPH),and to provide evidence for therapeutic regimen selection.Methods Prospective cohort study was applied.BPH patients were treated by two operative methods randomly,follow-up observations were carried out at 3 months,6 months,and 48 months after the treatment.IPSS and BPHQLS were adopted to evaluate prostate and quality of life of patients at different time.The weight coefficients of IPSS score,quality of life score and general hospitalization expense in the comprehensive evaluation were defined by the Delphi Method.Results The synthetic score of both groups showed ascending trend,comprehend evaluation of scores got after treatment for 3 months (OP group was 7.6±0.7,TURP group was 7.4±0.8),6 months(OP group was 6.9 ± 0.9,TURP group was 6.9 ± 1.1) showed no significant differences between two groups(P＞0.05),curative effect of OP group was better than TURP group at 48 moths(OP group was 8.3±0.9 score,TURP group was 7.6± 0.8 score) (P＜0.05).Conclusions The curative effect of OP group was better than TURP group at 48 months.