Coarctation of aorta is a discrete narrowness of the aorta and most commonly occurs in the isthmus.It is a common congenital cardiovascular malformation with morbidity of 5％ ～ 8％ among all congenital heart defects.Coarctation can result in the increase of upper limb blood pressure,the decrease of limb blood pressure,and a decline in cardiac function.Treatments include surgical repair and percutaneous interventions with different complications.Long-term complications and heart functions are important indices for evaluating prognosis and should be closely evaluated postoperatively.This review focuses on progresses of therapy methods,postoperative complications and cardiac function.

By using traditional Chinese medicine inheritance support system to analyze the dominant experience and recessive principles of the prescriptions for stranguria in the dictionary of traditional Chinese medicine prescription (DCMP), we aim to define the medication pattern and rule and to acquire new prescriptions. In dominant experience analysis, we were able to find 22 drugs used over 50 times, including drugs of clearing heat, diuresis and relieving stranguria which are the most used and drugs of clearing heat, cooling blood, benefiting Qi and nourishing Yin. In addition, drugs of activating Qi and Xue, eliminating phlegm and removing toxic are often used, including 34 herb pairs and 5 combinations of three-taste drugs are used more than 35 times. These results fully reflect the composition principles and compatibility characteristic of prescriptions for treating stranguria in DCMP. Thirteen new prescriptions by way of recessive principle excavating were acquired. These new prescriptions might be suitable to clinical treatments of variable syndromes. This article provides an useful clue to research and produce new drugs.
Cluster Analysis ; Dictionaries as Topic ; Drug Prescriptions ; Humans ; Medicine, Chinese Traditional ; methods ; Urination Disorders ; drug therapy

Objective To explore the spatial distribution of Keshan disease(KD) in the 15 surveillance provinces(municipalities,autonomous regions ) and to provide the basis for the development of prevention and control strategies.MethodsBased on the KD surveillance data of the 15 provinces in 2007,five indicators were selected.Moreover,a comprehensive indicator score to assess KD of different areas was made through the method of principle components analysis,which was applied for regionalization of the KD areas by the subsection method of standard deviation in whole China.The KD areas were divided into mild,moderate and severe endemic areas.The spatial distribution feature of the comprehensive indicator score was displayed by using geographic information system (GIS).ResultsThe three principal components contained 88.123％ information of all the selected indicators,the first principal component had a close relationship with total KD detection rate,chronic KD detection rate and latent KD detection rate; the second principal component had a close relationship with the threatened number in KD areas,and the third principal component had a close relationship with new KD detection rate; the comprehensive indicator indicates that Gansu,Jilin,Heilongjiang,Hebei,and Liaoning provinces were serious prevalent KD areas; Inner Mongolia,Shandong,Hubei,Sichuang provinces (autonomous region) were moderate prevalent KD areas,and Shanxi,Shaanxi,Yunnan,Henan,Guizhou,Chongqing provinces(municipality)were mild prevalent KD areas.Conclusions The introduction of the GIS to Keshan disease monitoring,provides a convenient and direct method to observe the spatial distribution of the disease,and the results point out the key areas for further KD surveillance according to local conditions.

AIM Action of adenosine triphosphate(ATP)on longitudinal muscle strips of the rat distal colon has been reported, however, that of the rat proximal colon remains to be clarified. In this study we investigated the effects of ATP on longitudinal muscle strips isolated from the rat proximal colon and the receptors involved in the effects. METHODSIsometric relaxant and contractile responses to ATP (0.1 μmol · L- 1 - 1 mmol· L- 1 ) and adenosine (1 - 100 μmol· L-1) in longitudinal muscle strips of the rat proximal colon were observed. RESULTS ATP (0.1 μmol· L- 1 - 1 mmol· L- 1 ) produced a complicated response including an inhibition of rhythmic contraction and a weakly transient decrease in basic tone (0.05-0.08 g) followed by a concentration-dependent contraction (0.04- 0.44 g) in longitudinal muscle strips of the rat proximal colon at resting tension. Tetrodotoxin (0.1 μmol·L-1) did not influence the responses to ATP.Adenosine (1 - 100 μmol· L-1) did not produce an obvious contractile response in the preparation at resting tension. Concentration-dependent relaxant responses to ATP ( 1 μmol· L- 1 - 1 mmol· L- 1 ) in the preparation precon tracted with 5-hydroxytryptamine or with acetylcholine were 23.2％ - 94.6％ or 24.8 ％ - 92.4％, however the relaxant responses to adenosine were much weaker than those to ATP. CONCLUSION ATP produces contractileresponsesmainly via purine and pyrimidine (P) 2receptors and relaxant responses partially via P1 receptors in longitudinal muscle strips of the rat proximal colon.

Objective To study the clinical effect of Fuyankangfupian in the treatment of patients with miscarriage caused by chronic endometritis and its influence on the inflammatory factor.Methods A total of 80 patients with miscarriage caused by chronic endometritis were enrolled in this study.The subjects were randomly divided into control group (n =40) and observation group (n =40).The control group was treated with conventional treatment,the experiment group was treated with Fuyankangfupian combined with conventional treatment.The clinical indicators,the visual analogue scale (VAS),serum levels of TNF-α,hs-CRP and IL-2 of the two groups before and after treatment were recorded and compared.Results After treatment,the abdominal pain time [(2.96 ± 0.88) d],bleeding time [(4.51 ± 1.12) d] and blood loss [(102.16 ± 21.82) mL] of the observation group were significantly lower than those of the control group[(6.83 ± 1.32)d,(7.14 ± 1.50)d,(174.28 ±33.35) mL,t =15.428,8.885,11.445,all P ＜ 0.05].The VAS scores in the control group and observation group after treatment were (4.57 ± 0.79) points,(2.12 ± 0.41) points,respectively,which were significantly lower than those before treatment[(8.68 ± 1.40) points,(8.72 ± 1.38) points,t =16.170,28.995,all P ＜ 0.05],which of the observation group was significantly lower than that of the control group (t =17.409,P ＜ 0.05).After treatment,the serum levels of TNF-α and hs-CRP in the control group and observation group were (2.61 ± 0.20) pg/mL,(6.40 ± 1.36) mg/L and (1.13 ± 0.12) pg/mL,(3.01 ± 1.02) mg/L,respectively,which were significantly lower than those before treatment[(3.95 ±0.31) pg/mL,(11.35 ± 3.14) mg/L and (4.02 ± 0.35) pg/mL,(11.52 ± 3.20) mg/L,t =22.972,9.149,49.400,16.025,all P ＜0.05],while the serum levels of IL-2 of the two groups after treatment were (4.13 ± 0.75) μg/mL,(7.12 ±0.91) μg/mL,which were significantly higher than before treatment[(1.98 ±0.51) μg/mL,(1.87 ± 0.60) μg/mL,t =14.993,30.462,all P ＜ 0.05].The serum levels of TNF-α and hs-CRP of the observation group were significantlylower than those of the control group (t =40.132,12.612,all P ＜ 0.05),serum level of IL-2 of the observation group was significantly higher than that of control group (t =16.036,P ＜ 0.05).Conclusion Fuyankangfupian can significantly reduce the abdominal pain,bleeding time and blood loss,ease abdominal pain and inflammation of the patients with miscarriage caused by chronic endometritis,it is worthy clinical application.

Objective To understand the perception of health status in people with prehypertension. Methods Using the phenomenological method, 15 people with prehypertension were interviewed; the interview results were analyzed deeply. Results Five themes were extracted about health status:obscured perception about prehypertension and hypertension;absence of noticeable symptoms;necessity to change life-style, but lack of effective health self-management; many factors hindering effective health self-management; desire for professional help. Conclusions Perception of health status in people with prehypertension indicated deficiencies in health self-management. What they need were accessible professional support and intervention program that pay attention to people′s health belief and behavioral motivation.

The 4 brands of subject librarian service in Tianjin University of Traditional Chinese Medicine in the past 10 year were summarized ( namely the mass organization of students, cooperation between universities and en-terprises, micro and new technology service, and innovative service) , and the subject librarians-faced challenges at present and in the future were elaborated, with suggestions proposed for improving their information literacy.

OBJECTIVE: To recognize the research status on the mechanism of reactive oxygen species (ROS) and NADPH oxidases in cell growth and death,and explore the effects of ROS and NADPH oxidases on cardiomyocyte differentiation.DATA SOURCES: A computer-based online search of Medline was undertaken for the articles about the action mechanism of reactive oxygen and NADPH oxidases in cell growth and death published in English between January 1997 and December 2003 with the key words of "Reactive oxygen species, NADPH oxidase, Cardiomyocytes, Differentiation, Signal transduction".STUDY SELECTION: Inclusive criteria: ①Articles on ROS production and structure and activation of NADPH oxidase and their action mechanism in cell growth and death; ②Research about the molecule mechanism of cardiomyocytes differentiation. The repetitive research and review articles were excluded.DATA EXTRACTION: Totally 132 articles about the action mechanism of ROS and NADPH oxidase and cardiomyocytes differentiation were collected, and 78 ones met the inclusive criteria.DATA SYNTHESIS: ①ROS involved in pathogenesis of many diseases were mainly from intramitochondrial electron transport chains, and NADPH oxidase was closely related with ROS production; NADPH oxidase firstly found in phagocyte was a kind of multienzyme complex, and its activity was regulated by the concentration of Ca2+ in cells and mRNA expression of its subunits. ②At present, many researchers presumed that oxidative stress was a double-edged sword, and it two-ways regulated the cell proliferation and death, in which ROS served as the second messenger in the signal transduction. Recent data showed that ROS and NADPH oxidase played important roles in cardiomyocytes differentiation; however, it was not identified which subunit of NADPH oxidase expressed in myocardial cells and its detail regulative pathway. Those problems were important for further study in the molecule mechanism of cardiomyocytes differentiation.CONCLUSION: ROS including superoxide anion (O2-), hydrogen peroxide (H2O2) and hydroxyl radical (OH-), are generated in cardiomyocytes mainly by a membrane-bound NADPH oxidase (NOX). The NOX-derived ROS, as the second passenger, play important roles in various intracellular signaling pathways. In cardiomyocytes, ROS have the potential to alter the balance between cell growth and death through these signaling pathways. Recently,ROS have been demonstrated to play a critical role in regulation of cardiomyocyte differentiation from embryonic stem cells. Research in the regulation mechanisms of ROS will contribute to our better understanding of he role of ROS and NADPH oxidase in cardicomyocyte differentiation and will lead to the identification of factors able to promote cardiac differentiation.

OBJECTIVE:To study the distribution characteristics and drug-resistance of the clinically isolated pseu-domonas aeruginosa in our hospital from Jan.2004to Aug.2005for the reference of clinics.METHODS:Different kinds of specimen for detection taken from the inpatients of our hospital were isolated and cultured,identification of strains was carried out by the conventional biochemical assay and susceptibility test was done by Kirby-Bauer method.RESULT:Of the total156pseudomonas aeruginosa isolated,64.74%were from the specimen of phlegm,followed by purulence surface of the wound at22.44%;In terms of its distribution in hospital departments,leading the list were neurosurgery,burn department and surgery,occupying34.62%,21.79%and16.03%,respectively.Pseudomonas aeruginosa was resistant to many antibiotics like cefazolin,furadantin,bactrim,etc.CONCLUSION:The choice of anti-pseudomonas aeruginosa infection drugs should be based on its drug susceptibility,which should be under frequent monitoring.