The article expounds the relationship of medical ethics and medical humanities education in a doctrinal aspect.Medical ethics possesses a more essential and inherent nature compared with medical humanities education,thus serves as the fundamental motivation and guide of medical practice for medical students and staff.Their relationship is clearly understood and the curriculum structure of medical education reasonably adjusted.The following will be beneficial reference for medical ethics cultivation for medical students: to strengthen all sidedness,positivism and interest of medical ethics education,medical humanities education served as evidence and complement for medical ethics education;to demonstrate ethical characteristics,profundity and intention of medical humanities education,medical ethics education also served as the aim and gist of medical humanities education.

The aging trend in China′s population sets an creasing demand for attention on senile people from both legal and emotional senses,including detailed and thoughtful humanistic hospice care.The traditional clinical service concept which values living while neglects dying should be modified,with a novel and overall humanistic hospice care for the dying and family members,in order to achieve the social harmony under the novel life value which enjoys living and a peaceful dying.

BacKground:Lymphocyte function-associated antigen-1( LFA-1 ) pIays a cruciaI roIe in the pathogenesis of infIammatory boweI disease by reguIating the activation and function of T ceIIs. Aims:To investigate the effect of LFA-1 deficiency( LFA-1-/-)on differentiation of mice na?ve T ceIIs into Th17 ceIIs in vitro. Methods:LFA-1-/- mice were breeded and the progeny genome DNA was extracted from the taiIs for genotyping by PCR. CD4+CD62L+ na?ve T ceIIs were separated from spIenic mononucIear ceIIs of LFA-1-/- progeny mice and wiId type ( WT ) C57BL/6J mice, respectiveIy,by magnetic-activated ceII sorting( MACS),and then the purity of separated ceIIs was determined. Na?ve T ceIIs obtained were cuItured in different inducing systems[ transforming growth factor-β( TGF-β),TGF-β + interIeukin-6 (IL-6),and TGF-β + IL-6 + IL-23]in vitro for Th17 ceII differentiation;ceIIs in each inducing system were coIIected for anaIyzing the ratio of Th17 ceIIs by fIow cytometry,and the expressions of Th17-specific transcription factor ROR-γt and Th17-specific marker IL-17A were measured by qRT-PCR and ELISA methods. Results:AII fifteen progeny mice were identified as LFA-1-/- genotype. Purity of CD4+CD62L+ na?ve T ceIIs separated by MACS was above 95%. Th17 ceIIs couId be induced by Iow-dose TGF-βcombined with IL-6,and the differentiation ratio was increased obviousIy when IL-23 was added. In inducing system containing TGF-β,IL-6 and IL-23,na?ve T ceIIs from LFA-1-/- mice produced more Th17 ceIIs than those from WT mice(17. 2% ± 1. 4% vs. 5. 7% ± 0. 2%,P<0. 001),expressions of ROR-γt mRNA and IL-17A mRNA were up-reguIated(P<0. 001),and IL-17A concentration in ceII cuIture supernatant was increased(P<0. 01). Conclusions:Deficiency of LFA-1 promotes the differentiation of mice na?ve T ceIIs into Th17 ceIIs in vitro.

By using traditional Chinese medicine inheritance support system to analyze the dominant experience and recessive principles of the prescriptions for stranguria in the dictionary of traditional Chinese medicine prescription (DCMP), we aim to define the medication pattern and rule and to acquire new prescriptions. In dominant experience analysis, we were able to find 22 drugs used over 50 times, including drugs of clearing heat, diuresis and relieving stranguria which are the most used and drugs of clearing heat, cooling blood, benefiting Qi and nourishing Yin. In addition, drugs of activating Qi and Xue, eliminating phlegm and removing toxic are often used, including 34 herb pairs and 5 combinations of three-taste drugs are used more than 35 times. These results fully reflect the composition principles and compatibility characteristic of prescriptions for treating stranguria in DCMP. Thirteen new prescriptions by way of recessive principle excavating were acquired. These new prescriptions might be suitable to clinical treatments of variable syndromes. This article provides an useful clue to research and produce new drugs.
Cluster Analysis ; Dictionaries as Topic ; Drug Prescriptions ; Humans ; Medicine, Chinese Traditional ; methods ; Urination Disorders ; drug therapy

Asthma, Occupational ; diagnosis ; Humans

Objective To investigate the changes of dopaminergic(DA) neurons in substantia nigra compact of the aged rats.Methods Using RT-PCR,Western blot,immunohistochemistry and electron microscope to detect the levels of TH mRNA and TH protein,the number and the ultrastructure of TH-positive neurons in the substantia nigra compact of the aged rats(≥24 months),and comparing those with adult rats(4～5 months).Results The level of TH mRNA(0.66?0.12) in substantia nigra compact of the aged rats was much lower than that in the adult rats(1.09?0.08)(P0.05).However,the number of TH-positive neurons in the caudal of substantia nigra compact of the aged rats was much lower than that of the adult rats(P

Ever from FDA approved the Rituxan in 1997,an Anti-CD-20 chimeric antibody,there have been more than 20 antibodies approved and they have got into more than 56 countries.About half approvied antibodies are curing kinds of cancers and seven of them have got a excellent sale targets to be "Blockbuster Drug".As the cell culture technology improving,the large scale cell expression titer comes from 1g/L to 5g/L.At the same time,the culture scale is coming form 12,000L to 15,000L,even 20000L and it can run several bioreactors at the same time.All these are make the improvement of the antibody purification.The new edition of media,system,chromatography technology and filtration technology can product the protein to several tens kilogram antibody per cycle and tons per year,although the productivity is only several kilograms per cycle many years ago.Also the new combined technology makes a two-step chromatography production protocol come into been.This will highly improve the antibody productivity and save the investment cost.

Objective To observe the clinical effects of transmission straight wire appliance on the treatment of AngleⅡ1 malocclusion and explore its mechanism.Methods Thirteen AngleⅡ1 malocclusion patients (6 males and 7 females) were treated with the appliance by extracting 4 first premolars or 2 first maxillary premolars.The results of cephalometric measurements before and after treatment were statistically analyzed.Results The average treatment time of 13 cases was 15.6 months.The overbite's treatment cost 4.2 months averagely.Overbite,overjet and molar relationship were turned to normal (only one adult case had complete distal in the molar relationship by extracting 2 first maxillary premolar) and lateral appearances were improved after treatment.The results of cephalometric analysis showed that the changes of SNB,ANB,U1-NA angle,L1-NB angle,U1-LI angle,U1-NA length,L1-NB length,L6-MP length,L1C-MP length,overbite,and overjet were of high statistical significance (P0.05).Conclusion Transmission straight wire appliance can quickly and efficiently correct AngleⅡ1 malocclusion.

To review recent studies on the research advance of RET( Rearranged during transfection) on-cogene in thyroid cancer,breast cancer,and lung cancer.The literatures on the structure of RET gene and coding product,cell signal transduction,relationship among thyroid cancer,breast cancer,and lung cancer are reviewed. RET gene encoding tyrosine kinase receptor,involving in cell signal transduction,rearrangement of RET gene is frequently seen in thyroid cancer,which is reported more and more in breast cancer,and lung cancer.Rearrange-ment of RET gene is closely correlated with the occurrence and progress of thyroid cancer,breast cancer,and lung cancer.Taking together,these findings suggest that RET present an attractive therapeutic target for the treatment of certain cancer subsets.

Objective To investigate prevalence of chronic diseases, and the awareness & attitudes, and the health demand of residents aged ≥18 yrs in Shanghai communities. Methods 2 320 residents aged over 18 yrs were selected from 19 communities by multiple stage cluster sampling and questioned by face to face survey. Results The standardized self-reported prevalence rate of whole chronic diseases was 28.4%, hypertension was 21.8%, osteoporosis was 7.0%, diabetes mellitus was 6.3%, respectively, which were ranked the top three. The awareness of the hypertension and diabetes mellitus were accounted to 89.3% and 86.0%. The demands for the convenient and comfortable clinical environment in residents accounted to 80.6%. Conclusion The prevalence of chronic diseases in Shanghai was high. It's suggested to enhance the control and prevention of chronic diseases, particularly on hypertension, and to do more health education in suburbs.