Nephrotic syndrome(NS) is a common disease in children.Glucocorticoids(GC) is the firstline treatment for NS and can cause growth hormone(GH) secretion and synthesis disorder through various ways which reduces levels of GH.Consequently,the growth and development are affected.For another,kddney disease can intervene in the secretion and regulation of insulin-like growth factor (IGF) and insulin-like growth factor binding protein(IGFBP).GH-IGF axis's change plays a role in children's growth retardation.Other factors,such as bone metabolic disturbance and hypothyroidism aggravates the growth inhibition.This review focuses on the prevention and treatment of growth retardation in children with NS.

Objective To explore the effect of serum uric acid ( UA ) level and its change in the incidence of nonalcoholic fatty liver disease( NAFLD) . Methods Subjects who participated in the adult health examination in a Top Three Hospital Medical Center of Guangzhou Province in 2012 and 2015, according to whether they have suffered from NAFLD after 3 years follow?up,were divide into NAFLD incidence group and negative control group. The data of anthropometry, laboratory examination and abdominal ultrasound were retrospective analyzed. Results There were 91 male in NAFLD incidence group and 317 males in negative control group. There were statistical significance in body weight ( Wt ) , BMI, UA, TG, HDL?C at baseline ( t=6. 10,4. 98,4. 21,1. 91,-4. 06;P<0. 05). According to UA<149 μmol/L,more than or equal to 149 to<416μmol/L,more than or equal to 416μmol/L as grouping standard,males detection of NAFLD in each group were 0 case,55 cases ( 19. 1%) , 36 cases ( 30. 3%) , and the difference was statistically significant compared with negative control group(χ2=6. 28,P=0. 012). According to UA<89 μmol/L,more than or equal to 89 to <357μmol/L,more than or equal to 357 μmol/L as grouping standard, females detection of NAFLD in each group were 0 case,91 cases( 20. 0%) ,39 cases( 37. 9%) ,and the difference was statistically significant compared with negative control group(χ2=14. 87,P=0. 001) . Age?adjusted partial correlation analyze showed that serum UA levels were positively correlated with Wt,BMI,SBP,DBP,BUN,SCr,ALT,TG and LDL?C levels,and negatively correlated with HDL?C levels( r=0. 349,0. 248,0. 152,0. 157,0. 201,0. 251,0. 132,0. 191,0. 148,-0. 228,P<0. 05) . There was no statistical significance between the NAFLD incidence group and the negative control group in the change of serum UA( z=0. 811,P=0. 417) . Binary Logistic regression analyze showed that the incidence of NAFLD was closely related to BMI,UA,ALT,TG and HDL?C at baseline,and the changes of Wt,ALT,TG, HDL?C during follow?up ( OR ( 95%CI ): 0. 767 ( 0. 709-0. 830 ) , 0. 996 ( 0. 994-0. 998 ) , 0. 964 ( 0. 937-0. 992),0. 702(0. 516-0. 955),4. 948(2. 414-10. 144),0. 890(0. 852-0. 930),0. 957(0. 937-0. 979), 0. 601(0. 441-0. 818),3. 111(1. 197-8. 080),P<0. 05). Conclusion Serum UA level is closely related to the incidence of NAFLD and its related risk factors, and serum UA level is an independent risk factor for NAFLD.

Objective To explore the clinical significance of monitoring the femoral artery hemodynamics of acute cerebral hemorrhage patients under general anesthesia by color doppler ultrasound .Methods Totally 30 patients who received emergency craniotomy for intracra-nial hematoma were performed the induction of general anesthesia and endotracheal intubation .The changes of femoral artery peak systolic ve-locity (Vs),early diastolic reverse peak velocity (Vd),systolic diameter (Ds),diastolic diameter (Dd),systolic blood pressure(SBP),dias-tolic blood pressure ( DBP) ,mean arterial pressure ( MAP) and heart rate ( HR) at each time point of before and after anesthesia induction , intubation,cutting the endocranium ,suturing the flaps were observed and recorded .Results Compared with those before anesthesia induc-tion,the MAP,VD and Vs were decreased (P<0.05),DS and DD increased (P<0.05) at each time point.Compared with those after anes-thesia induction,MAP and VD increased,VS reduced(P<0.05) at the intubation moment,the changes of DS and DD was not statistically significant,which compared with those after cutting the endocranium ,MAP,VS and VD decreased,but DS and DD increased (P<0.05).The changes of HR at each time point was not statistically significant (P>0.05).Conclusion Color doppler ultrasound could reflect the femoral artery hemodynamics of patients who subjected to craniotomy for intracranial hematoma under general anesthesia ,which provides some guid-ance for the general anesthesia strategies .

Objective To investigate the effect of Deanxit in treatment of Irritable bowel syndrome in patients in hematological index and intestinal sensitivity.Methods 82 cases with Irritable bowel syndrome were selected and divided into two groups, each had 41 cases.Control group was treated with conventional therapy, experiment group was treated on the base of the treatment with Deanxit.Hematology ndex and intestinal sensitivity index and clinical effect were compared after treatment.Results Compared with pre-treatment, plasma SS, SP and 5-HT decreased in two groups after treatment, NPY increased, levels of TNF-α, IL-6 and IL-8 decreased, levels of IL-10 increased, abdominal pain score, abdominal distension and diarrhea score score decreased, the differences were all significant(P<0.05).Compared with control group, plasma SS, SP and 5-HT in the experiment group were lower, NPY was higher, levels of TNF-α, IL-6 and IL-8 were lower, levels of IL-10 were higher, abdominal pain score, abdominal distension and diarrhea score score were lower than control group, the differences were all significant ( P <0.05 ) .Conclusion Deanxit in the treatment of Irritable bowel syndrome has curative effect.

Objective To explore the levels and the significance of IL-11 and sgp130 in the treatment of newly-diagnosed acute leukemia(AL)during the treatment of the induced remission,and to evaluate the curate effect of rhIL-11 on AL.Methods The levels of IL-11 and sgp130 in patients with AL were determined by ELISA respectively before treatment and after completing remission(CR).1.5 mg of rhIL-11 was injected subcutaneously,once a day,continuously for 14 days as one course,of treatment time 1～2 courses as total.Results Plasm IL-11 level in AL patients was significantly lower than normal(P

BACKGROUND: DNA enzyme targeting early growth response factor 1 (Egr-1) mRNA (ED5) can inhibit expression of downstream target genes by specificaly inhibiting expression of early growth response factor 1. OBJECTIVE:To investigate the effects of ED5 on the expression of plasma tissue factor after vascular baloon injury in rats and the mechanism of inhibiting neointimal hyperplasia. METHODS: Intimal injury models of the left carotid artery were made in rats. Then, ED5, MgCl2 and FuGene6 were injected into the injured vascular segment. RESULTS AND CONCLUSION:At days 3, 7, 14, 21, the expression levels of Egr-1 and tissue factor in plasma were significantly down-regulated in the ED5 transfection group compared with the MgCl2 and FuGene6 groups (P < 0.01); and neointimal hyperplasia was significantly inhibited by ED5 at days 7, 14 and 21 after modeling (P < 0.01). ED5 may inhibit neointimal hyperplasia folowing baloon injury of rat common carotid artery through down-regulation of tissue factors.

Objective: To assess the effect and safety of Qingwei Zhitong Pill(QZP) in treating duodenal ulcer with fire stagnation syndrome. Methods: A randomized, double-blinded double-mimic controlled trial was adopted. Sixty patients were treated with QZP, 60 with Sifang Wei tablet(SWT) and 40 served as the open treatment group. Results: In QZP group, the markedly effective rate evaluated by gastroscopy was 48.33%and the total effective rate was 76.67%; the markedly effective rate in relieving TCM syndromes was 73.33%and the total effective rate was 88.33%, the differences between the treatment group and the control group were significant (P

Objective To establish a method for content determination of hyodeoxycholic acid in Qingkailing Injection. Methods An UltimateXB-C18 column (5 ?m, 250 mm?4.6 mm) was used with a mobile phase of acetonitril-water-phosphoric acid (35∶65∶0.1). The flow rate was 1 mL/min. The temperature of the column was 40 ℃. The detection wavelength was 192 nm. Results There was a good linear relationship between the concentration of hyodeoxycholic acid and absorption area value in range of 0.201 35～1.006 75 mg/mL, r=0.999 6. The average recovery was 98.25% with RSD=1.26%. Conclusion This method was accurate, credible and repeatable which can be used to control the quality of Qingkailing Injection.

Objective To investigate the expression of CDX2 and its clinical significance in gastric intestinal epithelial tissue,and investigate the relationship between expression of CDX2 and infection of Helicobacter pylori.Methods The expression of CDX2 was studied by immunohistochemical technique in 93 cases of gastric mucosa (including 7 cases of normal gastric mucosa,21 cases of superficial gastritis,22cases of atrophic gastritis,43 cases of atrophic gastritis with intestinal metaplasia).14C urea breath test was used to detect the Helicobacter pylori infection.Results Helicobacter pylori was negative in 7 cases of normal gastric mucosa,the positive rate of Helicobacter pylori infection in atrophic gastritis and atrophic gastritis with intestinal metaplasia was 77.27％ (17/22),65.12％ (28/43),significantly higher than that of superficial gastritis [ 19.05％(4/21 )] (P ＜0.01 ).No expression of CDX2 was observed in normal gastric mucosa and superficial gastritis.The positive rate of CDX2 in atrophic gastritis with intestinal metaplasia was 83.72％(36/43 ),which was higher than that in atrophic gastritis [40.91％(9/22)](P＜ 0.01 ).Conclusions The infection of Helicobacter pylori and the expression of CDX2 are significantly associated with intestinal metaplasia.The abnormal expression of CDX2 might be the origin of intestinal metaplasia.The detection of gastric mucosa of CDX2 expression can be used to identify the intestinal metaplasia of gastric mucosa,predict the progress of gastric precancerous lesions,and provide a basis for the selection of treatment program.

Objective To study the clinical effect of Fuyankangfupian in the treatment of patients with miscarriage caused by chronic endometritis and its influence on the inflammatory factor.Methods A total of 80 patients with miscarriage caused by chronic endometritis were enrolled in this study.The subjects were randomly divided into control group (n =40) and observation group (n =40).The control group was treated with conventional treatment,the experiment group was treated with Fuyankangfupian combined with conventional treatment.The clinical indicators,the visual analogue scale (VAS),serum levels of TNF-α,hs-CRP and IL-2 of the two groups before and after treatment were recorded and compared.Results After treatment,the abdominal pain time [(2.96 ± 0.88) d],bleeding time [(4.51 ± 1.12) d] and blood loss [(102.16 ± 21.82) mL] of the observation group were significantly lower than those of the control group[(6.83 ± 1.32)d,(7.14 ± 1.50)d,(174.28 ±33.35) mL,t =15.428,8.885,11.445,all P ＜ 0.05].The VAS scores in the control group and observation group after treatment were (4.57 ± 0.79) points,(2.12 ± 0.41) points,respectively,which were significantly lower than those before treatment[(8.68 ± 1.40) points,(8.72 ± 1.38) points,t =16.170,28.995,all P ＜ 0.05],which of the observation group was significantly lower than that of the control group (t =17.409,P ＜ 0.05).After treatment,the serum levels of TNF-α and hs-CRP in the control group and observation group were (2.61 ± 0.20) pg/mL,(6.40 ± 1.36) mg/L and (1.13 ± 0.12) pg/mL,(3.01 ± 1.02) mg/L,respectively,which were significantly lower than those before treatment[(3.95 ±0.31) pg/mL,(11.35 ± 3.14) mg/L and (4.02 ± 0.35) pg/mL,(11.52 ± 3.20) mg/L,t =22.972,9.149,49.400,16.025,all P ＜0.05],while the serum levels of IL-2 of the two groups after treatment were (4.13 ± 0.75) μg/mL,(7.12 ±0.91) μg/mL,which were significantly higher than before treatment[(1.98 ±0.51) μg/mL,(1.87 ± 0.60) μg/mL,t =14.993,30.462,all P ＜ 0.05].The serum levels of TNF-α and hs-CRP of the observation group were significantlylower than those of the control group (t =40.132,12.612,all P ＜ 0.05),serum level of IL-2 of the observation group was significantly higher than that of control group (t =16.036,P ＜ 0.05).Conclusion Fuyankangfupian can significantly reduce the abdominal pain,bleeding time and blood loss,ease abdominal pain and inflammation of the patients with miscarriage caused by chronic endometritis,it is worthy clinical application.