1.Chrysotile and lung cancer —— 27 year follow up study
Zhiming WANG ; Mianzheng WANG ; Yiajia LAN
Chinese Journal of Industrial Hygiene and Occupational Diseases 2001;19(2):105-107
Objective To explore whether excess risk of malignant tumor,especially lung cancer in workers simply exposed to chrysotile. Methods A fixed prospective cohort was established.515 male exposed workers employed at least over one year in chrysotile plant in Jan 1,1972 were as study cohort and 650 male unexposed workers selected from a comparable plant were as control cohort,and the study was followed up for 27 years(Jan 1,1972～Dec 31,1998). Results (1)There were 50 cases died of all cancer in the study cohort (SMR=144),22 of them with lung cancer(SMR=652),whereas 11 cases died of all cancer in the control cohort (SMR=34) and 3 of them with lung cancers (SMR=89).The differences of all cancers and lung cancer between two cohorts were significant (P<0.05).(2)The lung cancer RR was 2.6 for unexposed smokers,12.2 for exposed but non smoking workers and 32.1 for exposed smokers.The index of synergistic effect of smoking and asbestos exposure was 2.2,indicating a multiplying effect to elevate the risk of lung cancer.(3)There were two mesotheliomas developed in chrysotile exposed workers. Conclusions Chrysotile could cause excess risk of lung cancer in exposed workers.
2.Chrysotile and lung cancer —— 27 year follow up study
Zhiming WANG ; Mianzheng WANG ; Yiajia LAN
Chinese Journal of Industrial Hygiene and Occupational Diseases 2001;19(2):105-107
Objective To explore whether excess risk of malignant tumor,especially lung cancer in workers simply exposed to chrysotile. Methods A fixed prospective cohort was established.515 male exposed workers employed at least over one year in chrysotile plant in Jan 1,1972 were as study cohort and 650 male unexposed workers selected from a comparable plant were as control cohort,and the study was followed up for 27 years(Jan 1,1972～Dec 31,1998). Results (1)There were 50 cases died of all cancer in the study cohort (SMR=144),22 of them with lung cancer(SMR=652),whereas 11 cases died of all cancer in the control cohort (SMR=34) and 3 of them with lung cancers (SMR=89).The differences of all cancers and lung cancer between two cohorts were significant (P<0.05).(2)The lung cancer RR was 2.6 for unexposed smokers,12.2 for exposed but non smoking workers and 32.1 for exposed smokers.The index of synergistic effect of smoking and asbestos exposure was 2.2,indicating a multiplying effect to elevate the risk of lung cancer.(3)There were two mesotheliomas developed in chrysotile exposed workers. Conclusions Chrysotile could cause excess risk of lung cancer in exposed workers.
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