Objective To study core needle biopsy in diagnosis of palpable breast cancer.Methods Retrospectively analyze core needle biopsy in 200 cases of palpable breast cancer.We recorded the clinical and pathology data and used crosstable test to analyze the effect of maximal and minimal tumor size.and TNM stage on the results. Results The ratio of success was 97%. No significant difference was found among the groups of different maximal tumor size, minimal tumor size and TNM stage (P ＞ 0.05 ). Conclusion ( 1 )For the diagnosis of the suspicious malignant palpable mass, core needle biopsy is effective, safe, microtraumatic and suitable to be used in different-class hospitals ; (2) The success of core needle biopsy for palpable breast cancer is correlated with dexterity of operator; (3)Biopsy channel should be in the range of operation and avoid of affecting sentinel lymphatic channels.

Objective To observe the RAS gene mutations in papillary thyroid carcinoma,and to analyse the effects of mutation on clinical characteristics and prognosis.Methods In this study,354 papillary thyroid carcinoma patients were divided into 2 groups according to RAS mutation by DNA sequence analysis.The pathological type,disease progression,recurrence and prognostic difference between the two groups were compared,and regression analysis was performed to evaluate the relationship between different variables and RAS mutation.Results There were 86 patients with RAS positive mutation.A significant difference was found with primary sites (P =0.004),distant metastasis (P =0.027),AJCC stage (P =0.004) and ATA risk stratification (P =0.000) between two groups.RAS positive patients have higher recurrence rate and shorter recurrence-free survival time (P ＜ 0.005) than the negative patients.Furthermore,in the multivariate analysis,the RAS mutation was significantly associated only with the ATA stratification.Conclusions RAS mutation increases risk of recurrence,RAS mutation and ATA stratification might be a valuable diagnostic and prognostic marker of papillary thyroid carcinoma.