1.A Clinical Study of Mycoplasma Pneumoniae Pneumonia.
Yeungnam University Journal of Medicine 1989;6(1):21-29
A clinical study was made on 71cases of Mycoplasma Pneumoniae Pneumonia from March, 86 to February, 89. The results were as follows; 1. Among the 315 cases of pneumonia, the incidence of mycoplasma infection was 22.5% 2. The peak incidence of age was between 5 to 9years of age (53.5%) 3. The sex ratio of male to female was 1.3:1 4. Monthly distribution showed relatively high frequency from October to January (59.2%) 5. Most common clinical symptoms were cough (98.6%) and then followed by fever (49.3%), coryza (19.7%). Rales were the most common finding (95.7%) and followed by pharyngeal injection (49.3%) and wheezing (18.3%) 6. The leukocyte counts in peripheral blood were most common in the range of 5000-10000/mm³ (47.9%) and the ESR was increased in 57.7%, and positive CRP cases were 87.3% 7. The most common radiologic finding of pulmonary infiltration was interstitial infiltration (45.1%) and then followed by disseminated lobular (39.4%) and lobar pneumonia (15.5%) 8. There are a few cases associated disease or complication: otitis media (5.6%), hepatitis (4.2%) acute glomerulonephritis, bronchial asthma and sinusitis (2.8%), thrombocytopenia (1.4%)
Asthma
;
Clinical Study*
;
Cough
;
Female
;
Fever
;
Glomerulonephritis
;
Hepatitis
;
Humans
;
Incidence
;
Leukocyte Count
;
Male
;
Mycoplasma Infections
;
Mycoplasma pneumoniae*
;
Mycoplasma*
;
Otitis Media
;
Pneumonia*
;
Pneumonia, Mycoplasma*
;
Respiratory Sounds
;
Sex Ratio
;
Sinusitis
;
Thrombocytopenia
2.Training satisfaction according to the type of family practice residency program.
Yun Ju KANG ; Mi Kyung OH ; Young Jin LEE
Journal of the Korean Academy of Family Medicine 1992;13(11):869-877
No abstract available.
Family Practice*
;
Humans
;
Internship and Residency*
3.Comparison of Fine Needle Aspiration Cytologic Diagnoses and Histologic Diagnoses in 256 Breast Lesions.
Mi Sun KANG ; Soo Jin JUNG ; Hye Kyoung YOON
Korean Journal of Cytopathology 1997;8(2):120-128
PURPOSE: Henoch-Schonlein purpura nephritis(HSPN) accompanied by nephrotic syndrome(NS) is known to have a poor prognosis and effective treatment is still controversial, even though both corticosteroids and immunosuppresant have been used for therapy. Cyclosporine A(CsA) is a well known immunosuppresant and widely used in renal transplantation and glomerular diseases especially steroid resistant. The aims of this study was to evaluate the therapeutic effect of CsA and to compare CsA with previously reported our data of rifampin(RFP) and azathioprine(AZA) in children with HSPN accompanied by NS. METHODS: 37 HSPN patients with NS confirmed by renal biopsy were selected. Of these, 17 patients were treated with CsA(5 mg/kg/day) for 6-8 months, 7 children were treated with RFP(10-20 mg/kg/day) for 9-12 months and 13 patients were treated with AZA(2 mg/kg/day) for 8 months. Along with these regimens, low dose oral prednisolone(0.5-1 mg/kg, qod) was also used. Sequential renal biopsy was done in all patients 1 month after termination of treatment. RESULTS: Complete remission rate of nephrotic syndrome was 5S.8% in CsA, 57.1% in RFP and 38.4% in AZA group after 17, 22, 11 months of mean follow-up period. Overall remission rate including partial remission was 88.2% in CsA, 85.7% in RFP and 84.6% in AZA group. Disappearance rate of hematuria was 58.8% in CsA, 57.1% in RFP and 46.2% in AZA group. Improvement of grade of clinical status was observed in 17 out of 17 CsA, 7 out of 7 RFP and 10 out of 13 AZA group. Improvement of pathologic class on sequencial renal biopsy was shown in 5 CsA(29.4%), none RFP(0%) and 2 AZA group(12.4%). Improvement on histologic immune-deposition was seen in 15 CsA(88.2%), 6 RFP(85.9%) and 4 AZA group(30.8%). CONCLUSION: In conclusion, Both CsA and RFP treated groups showed better result in complete remission rate of nephrotic syndrome and significant inprovement of histologic immune-deposition compared with AZA treated group(p=0.004). So, we recommend CsA and RFP rather than AZA for immunosuppresant treatment in HSPN with nephrotic syndrome.
Adrenal Cortex Hormones
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Biopsy
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Biopsy, Fine-Needle*
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Breast*
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Child
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Cyclosporine
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Diagnosis*
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Follow-Up Studies
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Hematuria
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Humans
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Kidney Failure, Chronic
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Kidney Transplantation
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Nephrotic Syndrome
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Prognosis
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Purpura, Schoenlein-Henoch
4.Tumorlet of Lung Associated with Congenital Bronchogenic Cyst: Report of a case.
Yeong Jin CHOI ; Mi Kyung JAE ; Seok Jin KANG ; Byoung Kee KIM ; Sun Moo KIM
Korean Journal of Pathology 1989;23(1):141-144
Tumorlet is a rare lesion of disputed origin that was first described by whitwell in 1955, and about one-third of the reported cases have been associated with underlying lung disease. Patient was a 60-year-old female who was admitted with a histroy of chest discomfort and dyspnea. Right lower lobe was partially resected under the clinical diagnosis of the bronchogenic cyst. Grossly, lung tissue around round cystic lesion appeared brown firm and somewhat fibrotic, and showed several scattered ill-defined whitish gray nodules. Microscopically, lung tissue around bronchogenic cyst was partially obliterated by dense fibrous scar tissue. Within this areas of fibrosis, and in the wall of alveolar ducts and respiratory bronchioles, innumerable microscopic tumorlets were found and argyrophilic granules were also demonstrated in scattered tumorlets with Grimelius stain.
Female
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Humans
;
Cysts
5.Sarcomatoid Transitional Cell Carcinoma of the Renal Pelvis A report of two cases.
Kyo Young LEE ; Mi seon KWON ; Yeong Jin CHOI ; Chang Suk KANG ; Seok Jin KANG ; Baying Kee KIM ; Sang In SHIM
Korean Journal of Pathology 1999;33(2):128-132
Sarcomatoid carcinomas are malignant epithelial neoplasms in which the tumor cells assume a partial or complete spindle cell pattern of growth, leading to the erroneous classification of some true carcinomas as sarcomas. These spindle cells are malignant and manifest various amount of both vimentin and cytokeratin. Positive reaction of some of the spindle cells for cytokeratin antibodies is confirmatory. Clinical features do not differ significantly from those of patients with high-grade transitional cell carcinoma. So far, 13 cases of sarcomatoid transitional cell carcinoma of the renal pelvis have been reported in English and Korean literature. In this report, we describe clinicopathologic features of recently observed two cases of sarcomatoid transitional cell carcinoma of the renal pelvis and summarize the pathologic findings of previously reported cases with review of the literature.
Antibodies
;
Carcinoma
;
Carcinoma, Transitional Cell*
;
Carcinosarcoma
;
Classification
;
Humans
;
Keratins
;
Kidney Pelvis*
;
Sarcoma
;
Vimentin
6.Extraskeletal Osteosarcoma of the Sole: A case report.
Ki Ouk MIN ; Mi Kyung JEE ; Seok Jin KANG ; Byoung Kee KIM ; Sun Moo KIM
Korean Journal of Pathology 1993;27(3):279-282
Compared with osteosarcoma of bone, primary osteosarcoma of the soft tissue is very rare. Extraskeletal osteosarcoma is also a highly malignant pleomorphic sarcoma composed of cells exhibiting primarily osteoblastic, and to a lesser extent, chondroblastic differentiation. A case of extraskeletal osteosarcoma in the right sole is presented in a 67 year old male. The patient had noticed a progressively enlarging soft tissue mass, during about 14 months. This sarcoma was located in the soft tissues without attachment to the skeleton, as determined by examination of the X-Ray findings. The mass of right plantar portion was simply excised and pathologically confirmed to be an extraskeletal osteosarcoma. The clinical and pathological features of this sarcoma are described, and brief review of the literature is made.
7.Three Cases of Late Hemorrhagic Disease of Ingancy.
Yang Su KANG ; Ree Sa LEE ; Sang Kyn PARK ; Ho Jin PARK ; Mi Ja SHIN
Journal of the Korean Pediatric Society 1989;32(7):1001-1006
No abstract available.
8.Cloning and expression of trypsin-encoding cDNA from Blattella germanica and its possibility as an allergen.
Mee Sun OCK ; Bong Jin KIM ; Sun Mi KIM ; Kang Hyun BYUN
The Korean Journal of Parasitology 2005;43(3):101-110
In this study, the trypsin gene (bgtryp-1) from the German cockroach, Blattella germanica, was cloned via the immunoscreening of patients with allergies to cockroaches. Nucleotide sequence analysis predicted an 863 bp open reading frame which encodes for 257 amino acids. The deduced amino acid sequence exhibited 42-57% homology with the serine protease from dust mites, and consisted of a conserved catalytic domain (GDSGGPLV). bgtryp-1 was determined by both Northern and Southern analysis to be a 0.9 kb, single-copy gene. SDS-PAGE and Western blotting analyses of the recombinant protein (Bgtryp-1) over-expressed in Escherichia coli revealed that the molecular mass of the expressed protein was 35 kDa, and the expressed protein was capable of reacting with the sera of cockroach allergy patients. We also discussed the possibility that trypsin excreted by the digestive system of the German cockroach not only functions as an allergen, but also may perform a vital role in the activation of PAR-2.
Allergens/analysis/chemistry/*genetics
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Amino Acid Sequence
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Base Sequence
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Blattellidae/*genetics
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Blotting, Western
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Catalytic Domain/genetics
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DNA, Complementary/genetics
;
Escherichia coli/metabolism
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Female
;
*Genes, Insect
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Humans
;
Male
;
Molecular Sequence Data
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Molecular Weight
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Receptor, PAR-2/metabolism
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Recombinant Proteins/analysis/biosynthesis/chemistry
;
Research Support, Non-U.S. Gov't
;
Sequence Alignment
;
Sequence Homology, Amino Acid
;
Trypsin/analysis/chemistry/*genetics
9.Mesenchymal Chondrosarcoma Arising from Orbital Soft Tissue: A case report.
Yu Mee KANG ; Mi Kyung JEE ; Seok Jin GANG ; Byung Kee KIM ; Sun Moo KIM
Korean Journal of Pathology 1989;23(2):273-277
Orbital mesenchymal chondrosarcoma, first described by Luis et. al in 1971, is a very rare tumor of characteristic histologic features. A 21-year-woman was admitted with a 4-month histoiry of rapidly progressive proptosis and visual disturbance. Right orbital exenteration was performed under the clinical diagnosis of orbital calcifying tumor. Grossly, the tumor presented as a multibloblated, circumscribed mass that measures 5.5 cm in the greatest dimentsion. Cut sections resembled ordinary chonrosarcoma. Microscopically, the tumor was composed of undifferentiated mesenchymal cells, interspersed nodules of well differentated cartilagenous tissue, areas of gradual transition from undifferentiated mesenchymal cells to cartilage, and hemangiopericytoma-like areas. A brief summary of the histopathological aspect of this tumor and a review of literature are presented.
Female
;
Humans
10.Comparison of Hospital Charge Prediction Models for Colorectal Cancer Patients: Neural Network vs. Decision Tree Models.
Seung Mi LEE ; Jin Oh KANG ; Yong Moo SUH
Journal of Korean Medical Science 2004;19(5):677-681
Analysis and prediction of the care charges related to colorectal cancer in Korea are important for the allocation of medical resources and the establishment of medical policies because the incidence and the hospital charges for colorectal cancer are rapidly increasing. But the previous studies based on statistical analysis to predictthe hospital charges for patients did not show satisfactory results. Recently, data mining emerges as a new technique to extract knowledge from the huge and diverse medical data. Thus, we built models using data mining techniques to predict hospital charge for the patients. A total of 1,022 admission records with 154 variables of 492 patients were used to build prediction models who had been treated from 1999 to 2002 in the Kyung Hee University Hospital. We built an artificial neural network (ANN) model and a classification and regression tree (CART) model, and compared their prediction accuracy. Linear correlation coefficients were high in both models and the mean absolute errors were similar. But ANN models showed a better linear correlation than CART model (0.813 vs. 0.713 for the hospital charge paid by insurance and 0.746 vs. 0.720 for the hospital charge paid by patients). We suggest that ANN model has a better performance to predict charges of colorectal cancer patients.
Algorithms
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Colorectal Neoplasms/*economics/epidemiology
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Comparative Study
;
*Decision Trees
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*Hospital Charges
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Humans
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Incidence
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Korea/epidemiology
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*Models, Econometric
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*Neural Networks (Computer)
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Predictive Value of Tests