PURPOSE: This study was done to evaluate the efficacy of Nei-Guan acupressure on nausea and vomiting in patients undergoing laparoscopic prostatectomy with intravenous patient controlled analgesia (IV-PCA). METHODS: Data were collected between August 13, 2012 and January 31, 2013 at a hospital in Busan. The participants were 45 men, who underwent the surgery laparoscopic prostatectomy, with IV-PCA. Data were analyzed using descriptive statistics, chi2-test, repeated measures ANCOVA and Games-Howell test with PASW 18.0. RESULTS: Nei-Guan acupressure had an interaction effect on nausea between group and time (F=5.01, p<.001), group (F=10.80, p<.001), time (F=26.51, p<.001) in laparoscopic prostatectomy with IV-PCA and also an interaction effect on vomiting between group and time (F=2.77, p=.032), group (F=8.89, p=.001), time (F=4.01, p=.022). CONCLUSION: Results indicate that nei-guan acupressure is a potentially effective therapy for the prevention of nausea and vomiting which occur with IV-PCA. Therefore, if patients complain of nausea and vomiting when receiving IV-PCA, nurses can provide patients with information about nei-guan acupressure and help them with nausea and vomiting.
Acupressure* ; Analgesia, Patient-Controlled* ; Busan ; Humans ; Male ; Nausea* ; Prostatectomy* ; Vomiting*

PURPOSE: The purpose of this study is to explore the experience of university students who witnessed of school violence during their formative years. METHODS: The participants in this study included 30 university students who had witnessed school violence. Analysis of the data was performed using content analysis according to Downe-Wamboldt. Data were collected from September 2015 to February 2016. RESULTS: Based on this study, there were four domains of school violence including witnessing, type of reaction, aftermath and future measures. According to the analysis, these four domains were classified into 13 variables, 32 categories and 73 significant statements. CONCLUSION: The results of this study suggest that further research is needed to develop measures to address problems that have developed for students who have witnessed school violence.
Humans ; Violence*

PURPOSE: The role of MRI in the detection of cholangiocarcinoma of the common hepatic duct has rarely been described. This study was attempted to ascertain characteristic MR features of cholangiocarcinoma. MATERIALS AND METHODS: The T1(500/30, TRs/TEs) and T2 weighted(200/80, TRs/TEs) MR images were obtained from nine patients with cholangiocarcinoma of the common hepatic duct. The common hepatic lesions were detected in seven cases. MR features of cholangiocarcinoma were analysed according to the signal intensity and associated findings. RESULTS: The seven cases showed lower signal intensity than the surrounding normal liver parenchyma on T1 weighted image. On T2 weighted image, the tumor showed isosignal intensity and hyperintensity in four and three patients, respectively. T2 image also revealed diffusely increased signal intensity in some hepatic lobe or segment in four cases, and Intrahepatic periductal high signal intensity in one case. Other associated MR findings were intrahepatic metastasis, and intratumoral hemorrhage, each noted in a different case. CONCLUSION: T2 weighted Image appears to be effective in the detection of cholangiocarcinoma of the common hepatic duct and evaluation of its associated intrahepatic lesions.
Cholangiocarcinoma* ; Hemorrhage ; Hepatic Duct, Common* ; Humans ; Liver ; Magnetic Resonance Imaging ; Neoplasm Metastasis

PURPOSE: The purpose of this study was to analyze factors affecting meaning of life in adolescents. METHODS: Data were collected from April 5 to June 20, 2010. The participants for this study were 343 Korean middle and high school students, recruited from four middle and high schools located in Seoul. Data collection was conducted through the use of 7 questionnaires. The data were analyzed with the SPSS WIN 12.0 program using descriptive statistics, ANOVA, Pearson correlation coefficients and stepwise multiple regression. RESULTS: 1) The mean total item score for the meaning of life scales was 2.99, which was slightly high. 2) There was a significant relationship between meaning of life and self-esteem, self control, parenting attitude, family satisfaction, school adjustment, and career maturity. 3) Stepwise multiple regression analysis showed that self-esteem, family satisfaction, school adjustment, parenting attitude and career maturity were predictors of meaning of life and accounted for 57.1% of the variance in meaning of life. CONCLUSION: Self-esteem, family satisfaction, school adjustment, parenting attitude and career maturity were variables influencing meaning of life in adolescents. These results indicate a need to develop nursing interventions to increase self-esteem, family satisfaction, school adjustment, parenting attitude and career maturity in order to improve meaning of life for adolescents.
Adolescent ; Data Collection ; Humans ; Parenting ; Parents ; Weights and Measures ; Child Health ; Surveys and Questionnaires

BACKGROUND: Histamine, released from mast cells in atheromatous plaque, has been known to cause cardiac ischemia or sudden cardiac death in atherosclerosis patient. Previous reports have suggested that histamine induced coronary vasoconstriction was due to increase in IP(3) and DAG, which induce release of Ca2+ from SR and increase the Ca2+ sensitivity of contractile element via activation of PKC. Recently, it was reported that application of histamine cause depolarization of intestinal smooth muscle, which may contribute to histamine-induced contraction via augmenting Ca2+ influx through activation of Ca2+ channels. However, the underyling mechanism of histamine-induced depolarization and its contribution to the magnitude of coronary vasoconstriction are still uncertain. METHOD: To elucidate the underlying mechanism of Ca2+ influx change during histamine-induced vasoconstriction, we examined the effect of Ca2+ channel antagonist and PKC blocker on histamine-induced contractions, and then measured the effect of PKC antagonist on whole cell K+ current using patch clamping method in rabbit coronary smooth muscle cells. RESULTS: Application of histamine induced phasic and tonic constraction of coronary rings via activation of H(1) receptors. Pretreatment of Ca2+ channel antagonist (nifedipine, 1 microM) or PKC blockers (10 nM staurosporine and 10 microM Go6976) markedly inhibited histamine-induced tonic contraction, which suggest that the magnitude of tonic contraction depend on the Ca2+ influx. Application of 4-AP, a blocker of voltage-dependent K+ channels, increased resting tone of coronary rings, and combined treatment of nifedipine blocked this 4-AP induced increase of resting tone. Application of active analoge of DAG (1,2-DiC(8)) significantly inhibited the activity of voltage-dependent K+ current in single smooth muscle cell, meanwhile the inactive analogue of DAG (1,3-DiC(8)) has no apparent effect on the activity of voltage-dependent K+ current. Furthermore, pretreatment of calphostin C (1 microM), a blocker of PKC, diminished the 1,2-DiC(8)-induced inhibition of K+ current. CONCLUSION: PKC dependent inhibition of voltage-dependent K+ current may be responsible for the maintaining of histamine-induced tonic contraction in rabbit coronary artery.
Atherosclerosis ; Constriction ; Coronary Vessels* ; Death, Sudden, Cardiac ; Histamine ; Humans ; Ischemia ; Mast Cells ; Muscle, Smooth ; Myocytes, Smooth Muscle ; Nifedipine ; Protein Kinase C ; Staurosporine ; Vasoconstriction

No abstract available.
Anemia, Aplastic* ; Hepatitis*

PURPOSE: The purpose of this study was to analyze the factors affecting Self Care Behavior in Korean high school students. METHOD: Data were collected from November 9 to December 28, 2003. The participants in this study were 293 students(134 boys, 159 girls), recruited from two High School located in Seoul. Data collection was conducted through the use of Questionnaire that was modified by the investigator. The data were analyzed with descriptive statistics, Pearson Correlation coefficients and stepwise multiple regression. The SPSS win 10.0 program was used. RESULTS: The mean of total item score the Self Care Behaviors scales was 3.37, which was slightly low. There was a significant correlation between Self Care Behavior, Hope, Social Support, and Self Care Agency(gamma= .30 ~ .65, p<.001). Stepwise multiple regression analysis showed that Self Care Agency was a predictor of Self Care Behavior and accounted for 28% of the variance. Self Care Agency account for 31% of the variance in Self Care Behavior in the high school girls. Self Care Agency and Hope accounted for 27% of the variance in Self Care Behavior in High school boys. CONCLUSION: Self Care Agency accounted for variance in Self Care Behavior in these high school students. Therefore it is necessary to develop nursing interventions to increase Self Care Agency in high school students in order to increase the Self Care Behavior.
Data Collection ; Female ; Hope ; Humans ; Nursing ; Research Personnel ; Self Care* ; Seoul ; Weights and Measures ; Child Health ; Surveys and Questionnaires

Both Mycoplasma hominis (M. hominis) and Ureaplasma urealyticum (U. urealyticum) are important genital mycoplasmas which are found in the cervix, vagina and the urogenital tracts of females. It has been associated with various disease states including non-gonococcal urethritis, spontaneous abortion, low birth weight and chorioamnionitis. Moreover they can be transmitted up to 40% of infants born to infected mothers. The culture methods which is commonly used for the determination of above mycoplasmas requires special culture media and can take up to 7 days. Recently the polymerase chain reaction (PCR) has been successfully applied for the detection of pathogenic microorganisms. In this study, M. hominis and U. urealyticum were determined using PCR in 70 vaginal swabs and 48 urine samples. In a total of seventy vaginal swabs, thirteen (18.5%) and twenty four (34.3%) samples were positive for M. hominis and U. urealyticum, respectively. In forty eight urine samples, M. hominis and U. urealyticum were found in 3 cases (6.3%), respectively. Among vaginal swab and urine samples, one case was found to be coinfectious state. Amplified DNA bands were more frequently found in vaginal swabs than urine samples. This study shows that PCR is a relatively simple, fast and practical tool for the detection of M. hominis and U. urealyticum in a clinical materials instead of culture method.
Abortion, Spontaneous ; Cervix Uteri ; Chorioamnionitis ; Culture Media ; DNA ; Female ; Humans ; Infant ; Infant, Low Birth Weight ; Infant, Newborn ; Mothers ; Mycoplasma ; Mycoplasma hominis ; Polymerase Chain Reaction* ; Pregnancy ; Ureaplasma urealyticum ; Urethritis ; Vagina

BACKGROUND: Impairment of relaxing response and augmentation of contractile response to vasoactive substances have been reported in atherosclerotic arteries. These alterations in vascular reactivity are considered as an underlying mechanism for the development of acute vasospasm in atherosclerotic coronary artery. Recently, it has been reported that lysophophatidylcholine (LPC), an oxidative metabolite of low density lipoprotein causes this functional abnormality. However, the precise mechanism of LPC induced change of vascular reactivity is still uncertain. METHOD: In this study, to elucidate the underlying mechanisms of abnormal vascular reactivity in atherosclerotic coronary artery, we examined the effect of LPC on whole cell K+current using patch clamping technique in rabbit coronary smooth muscle cells. RESULTS: Application of LPC(1microM) showed dual effect on whole cell outward current which depends on the magnitude of test potentials. At relatively high depolarizing test potentials (> 10 mV), LPC increased amplitude of outward current which was blocked by Gd3+ not by iberiotoxin (100 nM) and TEA (1 mM). Reversal potential of this Gd3+sensitive, LPC-induced current was -9.7 +/- 0.6 mV. At less depolarizing test potentials (< 10 mV), LPC decreased whole cell K+currents in a dose dependent manner (from 0.01 to 10 microM) in the range of -30 mV to +0 mV. Half maximal inhibition of K+current was 1.509 microM at 0 mV test potential (n =5). Depolarizing holding potential (0 mV) prevented this LPC-induced inhibition of K+current. Steady state activation and inactivation parameters of K+current were significantly shifted to the positive direction by application of LPC (p < 0.01, n =8). Pretreatment of staurosporine (100 nM), a blocker of protein kinase C partially blocked LPC-induced decrease of K+currents. CONCLUSION: LPC-induced inhibition of voltage dependent K+current may explain abnormal vascular reactivity in atherosclerotic coronary artery.
Arteries ; Constriction ; Coronary Vessels ; Lipoproteins ; Lysophosphatidylcholines* ; Muscle, Smooth* ; Myocytes, Smooth Muscle* ; Protein Kinase C ; Staurosporine ; Tea

No abstract available.
Mucopolysaccharidosis II*