1.Cumulative Incidence and Risk Factors of Diabetic Retinopathy.
Gyung Chun KIM ; Ki Woo AHN ; Young Mi CHUN
Journal of the Korean Ophthalmological Society 1995;36(7):1147-1154
In order to investigate the cumulative incidence and risk factors for diabetic retinopathy among non-insulin dependent diabetes mellitus, 116 patients which given diagnosis of diabetes at age 30 years or older who had been followed-up for more than 10 years and were initially free from retinopathy were analysed retrospectively. Several risk factors for retinopathy were analysed at the initial examinations: sex, age at the onset, age at the initial examination, duration, fasting plasma glucose(FPG), two-hour postpradial plasma glucose(pp2), blood pressure, hypertension status, therapeutic regimen, total cholesterol, HDL-cholesterol, triglyceride, body mass index. After a mean follow-up time of 11.7 years. The cumulative incidence was 31.0%. By univariate analysis. Significant risk factors of retinopathy were age at the onset, age at the initial examination. FPG, PP2, therapeutic regimen. However, By using multivariate analysis. Independent risk factors were not found.
Blood Pressure
;
Body Mass Index
;
Cholesterol
;
Diabetes Mellitus
;
Diabetic Retinopathy*
;
Diagnosis
;
Fasting
;
Follow-Up Studies
;
Humans
;
Hypertension
;
Incidence*
;
Multivariate Analysis
;
Plasma
;
Retrospective Studies
;
Risk Factors*
;
Triglycerides
2.Membrane - bound Cathepsin B - like Protease Activity in Malignant Skin Tumors.
Mi Ran LEE ; Mi Soon PARK ; Seung Chul LEE ; Young Ho WON ; Young Pio KIM ; Inn Ki CHUN
Korean Journal of Dermatology 1994;32(6):971-976
BACKGROUND: Malignant skin tumor cells derived from epidemal keratinocyte penetrate the basement membrane to proliferate in dermal interstitial strozirarnd invade surrounding tissue and finally metastasize to distant organs. In this stage of invaiac a and metastsis, the existence of proteolytic enzymes, which are capable of degrading the tissue barrier composed primarily of collagen, elastin, glycoproteins and proteoglycans, is imagnant. One of theses enzymes, cathepsin B, a lysosomal thiol protease, has been reported to ie ound in association with plasma membrane in animal and human tumors and to be releasec b tumor cells. OBJECT: We assayed the cathepsin B activities of squamo is cell carcinoma and basal cell carcinoma in order to investigate the correlation between the degree of cathepsin B activities and invasiveness or metastatic potential of skin tumors. METHODS: Cathepsin B-like protease activity was measurec by the method of Hirao using a synthetic substrate, Z-Phe-Arg-MCA. The skin tissues (penie Koreskin for control, basal cell carcinoma and squamous cell carcinoma tumor masses) were homogenized and their subcellular organelles were fractionated by centrifugation. Each of the fractionated preparations were used as enzyme solution. RESULTS: Cathepsin B-lilke activities were found mainly in the membrane fractions in all the samples. The activities of squamous cell carcinoma (12.484+1.904) and basal cell carcinoma (10.598+1.926) were higber than those of the control skin (9.115+0.815). CONCLUSION: These results suggest that membrane-bound conrt epsin B-like protease participates in local dissolution of the extracellular matrices and were ar endothelial cells to be able to make metastasis to other remote organ during the invasivest ges of malignant skin tumors.
Animals
;
Basement Membrane
;
Carcinoma, Basal Cell
;
Carcinoma, Squamous Cell
;
Cathepsin B*
;
Cathepsins*
;
Cell Membrane
;
Centrifugation
;
Collagen
;
Elastin
;
Endothelial Cells
;
Extracellular Matrix
;
Glycoproteins
;
Humans
;
Immunohistochemistry
;
Keratinocytes
;
Membranes*
;
Neoplasm Metastasis
;
Oncogenes
;
Organelles
;
Peptide Hydrolases
;
Proteoglycans
;
Skin*
3.A Case of Toxic Epidermal Necrolysis.
Gye Ja LEE ; Yong Aee CHUN ; Young Mi HONG ; Young Min AHN ; Se Hoon PARK
Journal of the Korean Pediatric Society 1986;29(3):110-
No abstract available.
Stevens-Johnson Syndrome*
4.Control Mechanisms of Ovarian Follicle Development by Follicle Stimulating Hormone and Pituitary Adenylate Cyclase-activating Polypeptide.
Yu Il LEE ; Jin Ok SHIN ; Mi Young KIM ; Sang Young CHUN
Korean Journal of Fertility and Sterility 2006;33(1):15-24
OBJECTIVE: Pituitary adenylate cyclase-activating polypeptide (PACAP), a novel hypothalamic neuropeptide, has been suggested to play a role in ovarian folliculogenesis. The present study evaluated the effect of PACAP on the growth of preantral follicles. METHODS: Preantral follicles were mechanically isolated from ovaries of 21-day-old rats and cultured in groups for 3 days in serum-free medium in the absence or presence of PACAP-38 (10-6 M). RESULTS: Treatment with PACAP-38 resulted in an increase in follicle diameter by 75% whereas treatment with follicle stimulating hormone (FSH) increased follicle diameter by 65%. PACAP-38 treatment enhanced the granulosa cell proliferation as measured by thymidine incorporation analysis. Furthermore, the production of progesterone by cultured granulosa cells and GFSHR-17 cell line was stimulated by PACAP-38. Interestingly, PACAP enhanced FSH action on stimulation of SF-1 and aromatase gene expression. CONCLUSION: The present results demonstrate that PACAP stimulated preantral follicle growth by potentiating proliferation and by stimulating steroidogenesis.
Animals
;
Aromatase
;
Cell Line
;
Female
;
Follicle Stimulating Hormone*
;
Gene Expression
;
Granulosa Cells
;
Neuropeptides
;
Ovarian Follicle*
;
Ovary
;
Pituitary Adenylate Cyclase-Activating Polypeptide*
;
Progesterone
;
Rats
;
Thymidine
5.Suitability of human amniotic fluid as a culture medium for human gamates.
Young Bum KIM ; Song Ki CHOI ; Jong Mi LEE ; Young Bae CHOI ; Kil Chun KANG
Korean Journal of Obstetrics and Gynecology 1993;36(7):2537-2543
No abstract available.
Amniotic Fluid*
;
Female
;
Humans*
6.Two cases of Korean hemorrhagic fever complicated with pregnancy.
Sun Hee CHUN ; Mi Young CHANG ; Young Ju KIM ; Bok Hee WOO
Korean Journal of Obstetrics and Gynecology 1992;35(5):778-782
No abstract available.
Hemorrhagic Fever with Renal Syndrome*
;
Pregnancy*
7.Cribriform-Morular Variant of Papillary Thyroid Carcinoma: A Report of Two Cases.
Young Ran SHIM ; Young Kyung BAE ; Joon Hyuk CHOI ; Mi Jin KIM ; Won Hee CHOI
Korean Journal of Pathology 2005;39(1):48-53
Cribriform-morular variant of papillary thyroid carcinoma is an unusual and peculiar subtype of papillary thyroid carcinomas. It occurs both sporadically and in association with familial adenomatous polyposis. We report here on two cases of cribriform-morular variant of papillary thyroid carcinoma in a 33-year-old woman and in a 21-year-old woman. On gross examination, both cases were multicentric. The first case showed two well-encapsulated yellow solid masses in the right (2.0 cm) and the left lobes of the thyroid gland (0.5 cm). The second case showed four well-encapsulated gray-white solid lobulating masses and nodules in the right (4.5 and 1.2 cm) and the left lobes (1.1 and 0.8 cm) of the thyroid gland. Microscopically, both cases exhibited an intricate blending of papillary, cribriform, trabecular, spindle, and solid patterns of growth with morular areas. Typical nuclear features of papillary carcinomas were focally seen. Immunohistochemically, the tumor cells were positive for thyroglobulin, thyroid transcription factor-1 (TTF-1), and beta-catenin, but were negative for calcitonin.
Adenomatous Polyposis Coli
;
Adult
;
beta Catenin
;
Calcitonin
;
Carcinoma, Papillary
;
Female
;
Humans
;
Thyroglobulin
;
Thyroid Gland*
;
Thyroid Neoplasms*
;
Young Adult
8.Treatment of Keratoacanthoma by 5 - Fluorouracil Intralesional Injection.
Mi Ran LEE ; Young Ho WON ; Seung Chul LEE ; Inn Ki CHUN
Korean Journal of Dermatology 1995;33(2):401-406
Keratoacanthoma is a rapidly growing, usually self-limited, hnil n tumor that has a striking rescmblance clinically ancl histologically to squamous cell carcinoma. Although thc keratoacanthorna is involuted spontaneously, then are several reasons why these lesions should treated. Treatment may hasten resolution, prevent extensive destruction of normal tissue, and improve she overall cosmetic result, and there are norabsolutely reliable diagnostic critcria to differcntiate these lesions from squamous cell carcinom complete excision is currently the choice of treatment or the majority of solitary keratoacanthims. However, this can lead to significant cosmetic or functional dcfects particularly in lesions located on intricate areas of thc face. Effective nonsurgical mclalities are rcquirced in such cases. Herein we report three cases of keratoacanthoma successfully reited by intralesional injection of 5-fluorouracil, and suggest that intralesional injection of 5-fluroiracil is a effective, safead convenient method of treatment for the multiplc keratoacahtnom and solitary lesions which are difficult to remove surgically.
Carcinoma, Squamous Cell
;
Dronabinol
;
Fluorouracil*
;
Injections, Intralesional*
;
Keratoacanthoma*
;
Strikes, Employee
9.Correlation of plain film and computed tomography findings of lobar atelectasis.
Ho Joon KIM ; Jeong Mi KWEON ; Yeon Won PARK ; Byung Hee CHUN ; Young Duk JOH
Journal of the Korean Radiological Society 1991;27(2):245-251
No abstract available.
Pulmonary Atelectasis*
10.Psychological Study of Dermographism Patients.
Inn Ki CHUN ; Mi Soon PARK ; Soung Hun KIM ; Young Pio KIM
Korean Journal of Dermatology 1987;25(3):318-325
The subjects of the present study was 300 out-patients and 304 people living in similar condition. The SCL-90(symptom check list-90) questionare was used and the two groups were compared by many factors. The rcsults were as follows. 1. All dimensional values of the dermographism group were much higher than the normal group except obsessive-compulsive dimension. The order of significance: Paranoid ideation, interpersonal sensitivity somatization, depression, anxiety, hostility and phobic anxiety(p<0. 01), The result indicates a significantly high incidence of psychological problems among dermographism patients. 2. In the dermographism group, the patients over 30 years old had significantly higher. scores in depression, anxiety, hostility and psychoticism. 3. Male patents showed significantly higher scores than female in paranoid ideation. 4. The unmarried patients had significantly higher scores in dcpression, para noid ideation and psychoticism. 5. Thc longer the duration of the disease was the higher the scores were. 6, There were no significant differences in educational status, family history, the job at onset of the disease, and the accuracy of understanding about the disease.
Adult
;
Anxiety
;
Depression
;
Dronabinol
;
Educational Status
;
Female
;
Hostility
;
Humans
;
Incidence
;
Male
;
Outpatients
;
Single Person