Mutations in the p53 gene seem to be the most common genetic changes in human malignancies. Mutation or altered p53 expression is a common occurrence in many solid neoplasms, including head and neck carcinomas. Recent studies have also shown p53 alterations in several premalignant conditions of the colon, esophagus, lung, and brain. Preliminary data have suggested that p53 mutations may be involved in tumor progression. This study was performed to determine the incidence of p53 mutations in histologically 27 squamous cell carcinomas, 19 basal cell carcinomas, 18 Schneiderian papillomas, 3 Schneiderian papillomas with malignant transformation, and 15 pleomorphic adenomas of the head and neck region. The degree of p53 gene overexpression was also evaluated according to differentiation, histologic type of tumor, and tumor progression in the head and neck carcinomas. The results were as follows; 1) Eighteen of 27 squamous cell carcinomas, and 4 of 27 dysplasias adjacent to the squamous cell carcinoma of the head and neck expressed p53 protein, but none of the normal control specimens expressed detectable p53 protein. There was no relationship between differentiation of squamous cell carcinoma and p53 protein expression. 2) Twelve of 19 basal cell carcinomas expressed p53 protein; the adenoid type especially overexpressed p53 protein. 3) Nine of 15 pleomorphic adenomas expressed p53 protein especially in the epithelial components. 4) Thirteen of 18 Schneiderian papillomas and all Schneiderian papillomas with malignant transformation expressed p53 protein. The above results indicate that the p53 protein expression is a useful tool for the prediction of tumor progression in the head and neck tumor, but there was no relationship between the differentiation of the tumor and p53 protein expression.
Humans ; Incidence ; Adenoma ; Genes, p53

BACKGROUND: The purpose of this study was to assess the effects of an exercise program using isometric and isotonic thera band exercises. METHODS: Data were collected from 30 total knee replacement patients hospitalized in the orthopedics department at 'B' hospital (control=15, experimental=15). The control group performed isometric exercises for one week while the experimental group performed three or more rounds of both isometric and isotonic exercises, including Thera-Band(R) exercises, everyday for four weeks. RESULTS: The experimental group improved significantly in muscular strength (Z=-1.99, P=0.047) and self-efficacy (Z=19.48, P=0.000), and showed lower levels of depression than the control group (Z=8.60, P=0.003). However, no difference was found in pain experience between the two groups. CONCLUSIONS: Exercise programs using the isometric and Thera-Band(R) resistance training improve muscular strength and self-efficacy and relieve depression in total knee replacement patients.
Arthroplasty, Replacement, Knee ; Depression ; Exercise ; Humans ; Orthopedics ; Resistance Training

OBJECTIVE: This survey assessed the prevalence and type of sexual dysfunction in middle-aged women regarding sexually related personal distress and examined the prevalence of perceived sexual dysfunction and perceived partners' dysfunction by women. METHODS: One-hundred ten healthy community-based middle-aged women participated voluntarily, and validated question- naires of the Female Sexual Function Index(FSFI) and the Female Sexual Distress Score(FSDS) were used. RESULTS: The percentage of women having sexual dysfunction and sexual distress were 67% and 32% respectively according to the cut-off of FSFI and FSDS. The average score of FSFI was 23.5(s.d.=5.7), which was lower than the cut-off of FSFI, while the average score of FSDS was 13.2, which was in range of a normal score. When considering the two concepts simultaneously, the women were categorized into 4 groups: sexually stressed dysfunction group (24.8%), sexually depressed group(42.2%), sexually healthy group(25.7%), and sexually hyperactive group (7.3%). The percentage of women reporting sexual problems was 24.3%, while the percentage of women reporting sexual dysfunction in their partner was 29.9%. CONCLUSIONS: The results indicate a high rate of sexual dysfunction and sexual distress in middle-aged women. However, considering the relationships between sexual dysfunction and sexual distress, almost two thirds were in the sexually depressed group among the women having sexual dysfunction.
Female ; Humans ; Middle Aged ; Prevalence

No abstract available.
Body Weight* ; Cholesterol*

No abstract available.
Humans ; Quality of Life* ; Renal Dialysis* ; Renal Insufficiency*

No abstract available.
Ileum*

PURPOSE: The purpose of this study was to provide basic research material necessary for the establishment of comprehensive nursing service units, through a comparative analysis of inpatient satisfaction with nursing between comprehensive nursing service and general units and the work stress of nurses. METHODS: The survey participants were inpatients and nurses from 3 general hospitals in Busan, including 6 units, 123 nurses and 220 patients. Date collection was done through March and April 2016. Collected data were analyzed using test and independent t-test with SPSS 23 Win program. RESULTS: Inpatients on comprehensive nursing service units had higher scores for satisfaction than inpatients on general units. There was no statistically significant difference in nurses' work stress between the two types of units. CONCLUSION: The findings indicate that although inpatient satisfaction with comprehensive nursing service units is higher than for general units, work stress for nurses is comparatively high for both types of units. While it is necessary to expand the implementation of comprehensive nursing service units, an institutional strategy for reducing nurses' work stress is required if the expansion is to be successful.
Busan ; Hospitals, General ; Humans ; Inpatients* ; Nursing Services* ; Nursing*

The purpose of this study was designed to develope and test the structural model that explains alcohol consumption behaviors among university students in Republic of Korea. The hypothetical model was constructed on the basis of the literature review and Pender's Health promotion model. Data was collected from questionnaires from 512 university students in Republic of Korea, from August to September, 2000. The reliability of instruments was adequate (Cronbach's alpha= .69-.90). Data analysis was done with SAS 6.12 for descriptive statistics and LISREL 8.13 program for covariance structural analysis. The results are as follows;1. The overall fit of the hypothetical model to the data was moderate. Thus it was modified by male and female models.2. The revised model has become parsimonious and had a better fit to the empirical data (male: x2=87.21 p=.00, GFI=.97, AGFI= .94, NFI=.99, NNFI=1.0, CN=619.17, female: x2=49.29 p=.31, GFI=.45, AGFI= .95, NFI=.99, NNFI=1.0, CN=370.02).3. Self-efficacy was most significant factor and personality of novelty seeking, reward compensation, alcohol expectancy and drinking attitude have significant effects on male alcohol consumption behavior. 4. Personality of novelty seeking was most significant factor and personality of harm avoidance, friend influence, self-efficacies, alcohol expectancy and drinking attitude have significant effects on female alcohol consumption behavior.
Alcohol Drinking* ; Compensation and Redress ; Drinking ; Female ; Friends ; Health Promotion ; Humans ; Korea* ; Male ; Models, Structural ; Surveys and Questionnaires ; Republic of Korea ; Reward ; Self Efficacy ; Statistics as Topic

Idiopathic thrombocytopenic purpura is an uncommon illness but most common form of thrombocytopema in pregnancy. Corticosteroids, splenectomy, immunosuppressive drugs, and immunoglobulin therapy have been recommended for manaaement. The optimal method of delivery is controversial. We have experienced a case of idiopathic thrombocytopenic purpura diagnosed previously and managed with corticosteroid and vincrstine, which was followed by pregnancy, vaginal delivery and postpiirtum splenectomy.
Adrenal Cortex Hormones ; Immunization, Passive ; Pregnancy* ; Purpura, Thrombocytopenic, Idiopathic* ; Splenectomy

A wide range of denomination has been used for inflammatory myofibroblastic tumor (IMT). IMT is not entirely homogeneous, even though it shows some overlapping histologic features such as haphazard proliferation of spindle cell and polymorphic chronic inflammatory cell infiltraion. The spindle cell is considered to be of myofibroblastic origin but follicular dendritic cell origin was reported recently. IMT is known as nonneoplastic, aberrant inflammatory response. However, IMT could show local invasion, recurrence, vascular invasion, and malignant transformation, and clonal characteristics and aneuploidy of IMT support the hypothesis that IMT may be a neoplastic process. In order to define the nature of spindle cell of IMT, immunohistochemical stains for smooth muscle actin (SMA), vimentin (VMT), lysozyme, S-100 protein, cytokeratin, CD21 were done. Additional immunohistochemical stains for MIB-1 for proliferating activity and LMP (latent membrane protein) for Epstein-Barr virus (EBV) were done. IMTs were composed of each 2 cases from lung, liver and lymph node and one case from common bile duct, maxillary sinus, bladder and thigh, and were histologically subclassified according to Coffin et al. Nine cases (90%) were positive for SMA and VMT, but no correlation between SMA and VMT immunoreactivity and histologic types was identified. Five cases (50%) were positive for lysozyme and S-100 protein, and histologic type III was negative for lysozyme and S-100 protein, and immunoreactivity for S-100 protein was different according to the histologic subtypes. All 11 cases were negative for CD21 and EBV LMP. MIB-1 labelling index was less than 1% in all cases. In summary, the spindle cell is regarded as myofibroblastic origin rather than follicular dendritic cell origin. Relationship with EBV is not clear, and negligible MIB-1 reaction suggests that IMT might have a good prognosis.
Actins ; Aneuploidy ; Coloring Agents ; Common Bile Duct ; Dendritic Cells, Follicular ; Herpesvirus 4, Human ; Immunohistochemistry ; Keratins ; Liver ; Lung ; Lymph Nodes ; Maxillary Sinus ; Membranes ; Muramidase ; Muscle, Smooth ; Myofibroblasts* ; Prognosis ; Recurrence ; S100 Proteins ; Thigh ; Urinary Bladder ; Vimentin