Keratoacanthoma is a rapidly growing, usually self-limited, hnil n tumor that has a striking rescmblance clinically ancl histologically to squamous cell carcinoma. Although thc keratoacanthorna is involuted spontaneously, then are several reasons why these lesions should treated. Treatment may hasten resolution, prevent extensive destruction of normal tissue, and improve she overall cosmetic result, and there are norabsolutely reliable diagnostic critcria to differcntiate these lesions from squamous cell carcinom complete excision is currently the choice of treatment or the majority of solitary keratoacanthims. However, this can lead to significant cosmetic or functional dcfects particularly in lesions located on intricate areas of thc face. Effective nonsurgical mclalities are rcquirced in such cases. Herein we report three cases of keratoacanthoma successfully reited by intralesional injection of 5-fluorouracil, and suggest that intralesional injection of 5-fluroiracil is a effective, safead convenient method of treatment for the multiplc keratoacahtnom and solitary lesions which are difficult to remove surgically.
Carcinoma, Squamous Cell ; Dronabinol ; Fluorouracil* ; Injections, Intralesional* ; Keratoacanthoma* ; Strikes, Employee

No abstract available.
Corneal Opacity ; Ehlers-Danlos Syndrome*

BACKGROUND: Malignant skin tumor cells derived from epidemal keratinocyte penetrate the basement membrane to proliferate in dermal interstitial strozirarnd invade surrounding tissue and finally metastasize to distant organs. In this stage of invaiac a and metastsis, the existence of proteolytic enzymes, which are capable of degrading the tissue barrier composed primarily of collagen, elastin, glycoproteins and proteoglycans, is imagnant. One of theses enzymes, cathepsin B, a lysosomal thiol protease, has been reported to ie ound in association with plasma membrane in animal and human tumors and to be releasec b tumor cells. OBJECT: We assayed the cathepsin B activities of squamo is cell carcinoma and basal cell carcinoma in order to investigate the correlation between the degree of cathepsin B activities and invasiveness or metastatic potential of skin tumors. METHODS: Cathepsin B-like protease activity was measurec by the method of Hirao using a synthetic substrate, Z-Phe-Arg-MCA. The skin tissues (penie Koreskin for control, basal cell carcinoma and squamous cell carcinoma tumor masses) were homogenized and their subcellular organelles were fractionated by centrifugation. Each of the fractionated preparations were used as enzyme solution. RESULTS: Cathepsin B-lilke activities were found mainly in the membrane fractions in all the samples. The activities of squamous cell carcinoma (12.484+1.904) and basal cell carcinoma (10.598+1.926) were higber than those of the control skin (9.115+0.815). CONCLUSION: These results suggest that membrane-bound conrt epsin B-like protease participates in local dissolution of the extracellular matrices and were ar endothelial cells to be able to make metastasis to other remote organ during the invasivest ges of malignant skin tumors.
Animals ; Basement Membrane ; Carcinoma, Basal Cell ; Carcinoma, Squamous Cell ; Cathepsin B* ; Cathepsins* ; Cell Membrane ; Centrifugation ; Collagen ; Elastin ; Endothelial Cells ; Extracellular Matrix ; Glycoproteins ; Humans ; Immunohistochemistry ; Keratinocytes ; Membranes* ; Neoplasm Metastasis ; Oncogenes ; Organelles ; Peptide Hydrolases ; Proteoglycans ; Skin*

Remeflin is known as an analeptic which stimulates the bulbar respiratory center, thereby causing an increase in pulmonary ventilation. The author observed the effect of Remeflin upon respiration i.e. tidal volume, minute volume and respiratory rate, and circulation, i.e. blood pressure and pulse rate, in postanesthetic patients. Ventilatory and circulatory changes were measured at 2 minutes. intervals up to 30 minutes. after intravenous injection of the drug (0. 25 mg/kg) to 40 patients in the recovery room. The results were as follows: 1) Remeflin significantly increased tidal volume and minute volume. 2) Remeflin did not significantly alter respiratory rate, blood pressure and pulse rste. 3) Improvement in the respiratory function by Remeflin was due to an increase in the depth of respiration. 4) Side effects by Remeflin were absent except for navsea or vomiting in a few cases.
Blood Pressure ; Heart Rate ; Humans ; Injections, Intravenous ; Pulmonary Ventilation ; Recovery Room ; Respiration* ; Respiratory Center ; Respiratory Rate ; Tidal Volume ; Vomiting

We experienced 450 cases of anesthesia for the operation of cleft lip and cleft palate. The observed results were as follows. 1) Anesthetics for the operation of cleft lip were 200 cases(44.4%), cleft palate were 248 cases(55.1%), naso-ocular fistula correction and oro-ocular correction was 1 case each. 2) Sex distribution was 298 males(66.2%) and 152 females(33.8%). 3) 292 cases(66%) were under 20kg of body weight. 4) The techniques of anesthesia were NRB with Jackson-Rees' modification in 297 cases (66%) and the semiclosed circle absorption system in 153 eases(34%). 5) The main anesthetics were halothane in 431 cases(95.8%) and Valium-Dmerol in 19 cases (0. 42%) 6) The mean blood loss in palatoplasty was 6.4 ml per kg of body weight but it was 10. 7 ml per kg in the 5~10 kg of body weight group, 9. 6 ml per kg in the 10-20 kg of body weight group, and 8. 5 ml per kg in the 20~30 kg of body weight group. 66 cases (14.7%) received blood transfusion. 7) Familial incidence was found in 4.7% (21 cases). 8) Incidence of cleft lip combined with cleft palate was 42.7%(192 cases among 450 cases), and 154 cases(51.7%) were males and 88 cases(25%) were females. 9) The most common type of cleft lip was incomplete left cleft lip(30%), and of cleft palate was complete median cleft palate(52%). 10) lntraoperative anesthetic complication occurred in 8 cases(1.8%).
Absorption ; Anesthesia* ; Anesthetics ; Blood Transfusion ; Body Weight ; Cleft Lip* ; Cleft Palate ; Female ; Fistula ; Halothane ; Humans ; Incidence ; Male ; Sex Distribution

We report a case of pulmonary edema developed in a 33-year-old female who underwent two-stage bilateral carotid body tumor excision. About 1 month ago, she had undergone a left carotid body tumor excision. After the operation, her tongue was deviated to left side. Bilateral hypoglossal nerve injury was suspected. These injuries should be carefully monitored in patients who will undergo a similar procedure on both sides because a bilateral deficit of the hypoglossal nerve is poorly tolerated, resulting potentially serious pulmonary edema. In recovery room, she became pale and SpO2 was fall down. We reintubated her immediately and the pulmonary edema was treated using a supportive management. She was discharged without any signs of dyspnea or airway obstruction, but hypoglossal nerve injury remained. We discuss the possible etiology of the upper airway obstruction after the neck surgery and review the literatures associated with the pulmonary edema following upper airway obstruction.
Adult ; Airway Obstruction ; Carotid Body Tumor* ; Carotid Body* ; Dyspnea ; Female ; Humans ; Hypoglossal Nerve ; Hypoglossal Nerve Diseases ; Hypoglossal Nerve Injuries ; Neck ; Pulmonary Edema* ; Recovery Room ; Tongue

Sedative and antiemetic effect of hydroxyzine as a premedicant were studied and results were compared with a placebo and Talwin. Two hundred and fourty patients were evaluated. These patients were divided into 6 groups. There were fourty patients in each group. Group 1: Hydroxyzine 50mg. Group 2: Hydroxyzine 100mg. Group 3: Placebo. Group 4: Talwin 20mg. Group 5: Hydroxyzine 5pmg plus Talwie 20mg. Group 6: Hydroxyzine 100mg plus Talwin 20mg. The results were as follows; 1) Satisfactory sedation was ovtained in 75% with group I, in 92.5% with group 2, in 30% with group 3, in 40% with group 4, in 82. 5% With group 5, and in 97. 5% with group 6. Better results were obtained with hydroxyzine plus Talwin group than hydroxyzine anly. 2) The incidence of postoperative nausea and vomiting in recovery room, 7. 5% wlth group 7. 5 % with group 3, 20% with group 4, 5%. with group 5. There was no case of nausea and vomiting in group 2 and group 6. We obtained a significant difference in antiemetic effect between Talwin only and the Talwin plus hydroxyzine group. 3) There was no adverse change on vital signs in all cases.
Antiemetics ; Humans ; Hydroxyzine* ; Incidence ; Nausea ; Pentazocine ; Postoperative Nausea and Vomiting ; Recovery Room ; Vital Signs ; Vomiting

The superoxide anion, hydrogen peroxide, and hydroxyl radical are oxygen free radicals which arise in cell metabolism and which are toxic to cells, with an important role in carcinogenesis. The measurement of the oxygen free radical is a problem due to the instantaneously changing nature, and therefore the superoxide dismutase(SOD) is employed which act as an oxygen free radical scavenger. The authors quantitatively analyzed the SOD levels in normal uterine cervix epithelium, cervical intraepithelial neoplasia, and in invasive cervical cancer patients by the SOD-525R spectrophotometric assay and compared the results between each group with respect to prognostic variables such as stage of disease, cell type, lymph node involvement, and SCC Ag(TA-4 Ag) levels. The mean SOD levels were 0.41U/ml, 0.39U/ml and 0.73U/ml in the normal uterine cervix, intraepithelial neoplasia, and invasive cervical cancer groups, respectively, showing statistically significant difference by the Oneway anova test(p=0.05). The mean SOD levels according to the stage of disease were 0.5U/ml, 0.62U/ml, and 1. 15U/ml for stages I a, I b, and stage II and above(p=0.029). For the cell type the SOD levels were 0.77/ml for squamous cell carcinoma and 0.57U/ml for adenocarcinoma(p=0.15). For cancer cell lymph node involvement cases, the mean SOD levels were 0.75U/ml and 0.57U/ml for lymph node involvement and no involvement respectively(p=NS). The mean SOD levels also did not show any significance when compared with SCC Ag levels where SOD was 0.78U/ml for SCC Ag levels of more than 2.0ng/ml, and 0.77U/ml for SCC Ag levels of less than 2.0ng/ml. From the above results the authors conclude that SOD levels were higher in invasive cervical cancer tissues compared to intraepithelial neoplasia and normal cervical tissues, that SOD levels increased with higher stage of disease, and that there was no relationship between SOD levels and known prognostic variables such as cell type, lymph node involvement and SCC Ag level.
Carcinogenesis ; Carcinoma, Squamous Cell ; Cervical Intraepithelial Neoplasia ; Cervix Uteri ; Epithelium ; Female ; Free Radicals ; Humans ; Hydrogen Peroxide ; Hydroxyl Radical ; Lymph Nodes ; Metabolism ; Oxygen* ; Superoxides* ; Uterine Cervical Neoplasms

No abstract available.
Animals ; Macrophages* ; Mice*

The isolated medial rectus muscle palsy without involvement of third cranial nerve is relative rare. Two cases were studied by coronal, transverse, axil computed tomography and MR imaging which showed the well visualization of intraorbital structures and confirmed same finding by operation with clinical improvement. It seemed to be necessary to study by comprehensive radiology for the exact localization and observation of intraorbital structures. We report two cases of isolated medial rectus muscle palsy associated with mucocele.
Magnetic Resonance Imaging ; Mucocele ; Oculomotor Nerve ; Paralysis*