No abstract available.
Myasthenia Gravis* ; Pregnancy*

PURPOSE: The purpose of this study was to determine the effects of labor intensity and fatigue on the sleep quality of clinical nurses and provide basic data for preparation of nursing interventions to improve sleep quality. METHODS: Data were collected from 198 nurses in 2 general hospitals with more than 500 beds in D-city. Data analysis was performed using stepwise regression with the SPSS/WIN 22.0 program. RESULTS: The significant factors influencing sleep quality of the clinical nurses were fatigue, absolute labor intensity, and shift type. Explanatory power was 66% in the regression model. CONCLUSION: Findings indicate that nurses with higher level of fatigue, and greater absolute labor intensity which implies extended work hours, had lower sleep quality for all the three shifts. To improve the sleep quality of clinical nurses, an intervention program for fatigue management is needed. In addition, hospitals should establish an internal legal standard to compensate overtime work with breaks. At the same time, as shift work is inevitable for nurses, it is necessary to develop a work system that can minimize the disturbance of daily rhythms.
Fatigue ; Hospitals, General ; Nursing ; Statistics as Topic

Background: Prevention of chronic diseases such as hypertension and diabetes is important, but few studies have identified barriers to healthy lifestyle practices among adults in their 30-50s. Therefore, this study is intended to be used as basic data for establishing a prevention and control strategy for chronic diseases. Methods: This study is a qualitative content analysis study using the focus group interview methodology. According to the inductive content analysis method, data were analyzed through the steps of ‘making sense of the data and whole’, ‘open coding’, ‘grouping’, ‘categorization’, and ‘abstraction’. Results: The categories of barriers to healthy lifestyle practice were derived as follows. ‘Low interest in health care’ in the intrapersonal domain, ‘absence of an assistant’ in the interpersonal domain, ‘organizational environment in which it is difficult to a healthy lifestyle practice’ in the organizational domain, ‘lack of infrastructure’ and ‘restrictions on use of public health centers’ in the community domain. Conclusions For the prevention and management of chronic diseases, adults in their 30-50s should be encouraged to take an interest in healthy lifestyle practices and increase their will. For healthy lifestyle practice, it is necessary to allow family members and friends to participate as helpers. In addition, at work, employers should pay attention to workers' health management, adjust working hours, and reduce the burden of company dinner to create an organizational environment for healthy lifestyle practice. Lastly, infrastructure such as public sports facilities should be additionally expanded, and the contents of public health centers' programs should be promoted.

PURPOSE: The purpose of this study was to identify the symptoms and interference of activities of daily living (ADL) of chemotherapy induced peripheral neuropathy (CIPN) in patients receiving taxane and platinums. METHODS: 141 cancer patients were recruited in the cross-sectional survey design. The instruments used in the study was the Chemotherapy-induced Peripheral Neuropathy Assessment Tool (CIPNAT) developed by Tofthagen and colleagues. RESULTS: The patients experienced the symptom and interference of ADL of CIPN moderately. The most common symptom was nerve pain (70.2%) and the patients with high cumulative doses showed a significant of tingling sensation in the feet. Symptom severity increased substantially with cumulative dose of chemotherapeutic agents. CONCLUSION: The results of this study suggest that chemotherapy-induced peripheral neuropathy increase due to repeated chemotherapy and nursing intervention is necessary to reduce symptom severity and interference of ADL of CIPN.
Activities of Daily Living* ; Bridged Compounds ; Cross-Sectional Studies ; Drug Therapy ; Foot ; Humans ; Neuralgia ; Nursing ; Peripheral Nervous System Diseases* ; Platinum* ; Sensation ; Taxoids*

Cervical large cell neuroendocrine carcinoma is rare. We experienced one case of cervical large cell neuroendocrine carcinoma with invasive mucinous adenocarcinoma in 49 years old woman. So we report the case and brief review of literature.
Adenocarcinoma, Mucinous* ; Carcinoma, Neuroendocrine* ; Cervix Uteri* ; Female ; Humans ; Middle Aged ; Mucins*

PURPOSE: The expression of matrix metalloproteinase-2 (MMP- 2) by cancer cells has been implicated in metastasis through cancer cell invasion of the basement membranes mediated by a degradation of collagen IV. However, the MMP-2 proenzyme requires proteolytic activation for its physiologic or pathologic role. We tried to 1) compare expression and activation of MMP-2 in breast cancers with benign tumors, 2) determine the correlation between the actviation of MMP-2 in breast cancer and established prognostic factors, 3) observe whether MMP-2 is expressed and activated in axillary lymph nodes as well, and 4) determine the degree of correlation between MMP-2 activity in lymph nodes and metastatic status, if MMP-2 is expressed in lymph node. METHODS: The specimens came from 11 fibroadenomas, 32 invasive ductal carcinoma and 129 axillary lymph nodes from cancer cases. Pro-MMP-2 cDNA transfected MDA-MB-231 cells were cultured and the conditioned media from them was used for a control. Zymography was used to monitor MMP-2 activation through the detection of the inactive proenzyme form (72 kDa) and the active form (62 kDa). Immunohistochemical staining was also performed for the localization of MMP-2 expression in tissues. RESULTS: 1) 72 kDa was expressed in all fibroadenomas and cancers, while 62 kDa was expressed in only 10 cases of fibroadenomas and all cancers. MMP-2 activity (62 kDa/72 kDa +62 kDa) was significantly higher in cancers than in fibroadenomas (P=0.014). 2) MMP-2 activity in cancers was significantly correlated with nodal metastasis (P=0.040). 3) The expression of MMP-2 in lymph nodes was very low and MMP-2 activity was not correlated with metastatic status. However, the immunohistochemical staining showed different staining patterns between the metastatic and non-metastatic nodes. CONCLUSION: We suggest that a measurement of the activation of MMP-2 could be useful as a prognostic marker representing metastatic potential in breast cancer. However, the low expression of MMP-2 in lymph nodes is an interesting subject for further study.
Basement Membrane ; Breast Neoplasms* ; Breast* ; Carcinoma, Ductal ; Collagen ; Culture Media, Conditioned ; DNA, Complementary ; Fibroadenoma ; Lymph Nodes ; Matrix Metalloproteinase 2* ; Neoplasm Metastasis*

No abstract available.
RNA, Messenger* ; Thyroid Gland*

Chronic recurrent multifocal osteomyelitis(CRMO) is an unusual inflammatory process involving multiple osseous sites. No causative agent can be consistently isolated from these lesions despite multiple biopsies and the affected child purses a clinical course of chronic remissions and exacerbations independent of antibiotic therapy. Biopsy of the lesions did not reveal any pathogens. Immunologic investigation revealed no abnormality common to the patient and there was no indication of a genetic etiology. The natural history of chronic recurrent multifocal osteomyelitis appears to be slow, spontaneous resolution of the osseous lesions without specific treatment. We experienced a case of CRMO in an 11-year-old girl who had complained of fever, pain on knee and wrist joints for several weeks. We studied the clinical, radiographic, histological findings in this patient and we report a case of CRMO with brief review of related literature.
Biopsy ; Child ; Female ; Fever ; Humans ; Knee ; Natural History ; Osteomyelitis* ; Wrist Joint

The incidence of multiple primary cancers is low than that of single primary cancer. In gastric cancer, incidence of occurrence of multiple primary cancer is 3 to 11.3%. Because stomach and lung are unrelated organs, the combination of gastric cancer and lung cancer is rare. Its estimated incidence is about 10% of all multiple primary cancers. The histologic types of secondary lung cancer in one series, squamous cell carcinomas were 49%; adenocarcinomas were 28%; large cell carcinomas were 14%; small cell carcinomas were 9%; others were 6%. This patient had been diagnosed as early gastric cancer 3 years ago, but he refused operation for cancer and wasnt followed up. After 3 years, he revisited us for dry coughing and diagnosed as small cell lung cancer. At this time, previous gastric cancer was remained as well differentiated, early gastric adenocarcinoma. For its rarity, we report this case with review of literatures.
Adenocarcinoma ; Carcinoma, Large Cell ; Carcinoma, Small Cell ; Carcinoma, Squamous Cell ; Cough ; Humans ; Incidence ; Lung ; Lung Neoplasms ; Small Cell Lung Carcinoma* ; Stomach ; Stomach Neoplasms*

No abstract available.
Radionuclide Imaging*