Granuloma pyogenicum is a benign vascular tumor, usually about 0.5 to 2cm in diameter. It occurs as a single lesion with few exceptions and consists of pedunulated nodule with a dull red or slightly purplish color. We observed a 29-year old man who had multiple satellite recurrences in the scapular region which developed after excision of a single lesion of granuloma pyogenicum. Histapathologic findings showed many newly formed capillaries that had prominant endothelial cells and showed varying degrees of dilation without appearance of epiderrnal collarette sign. The lesions were much improved by X-ray irradiation.
Adult ; Capillaries ; Endothelial Cells ; Granuloma* ; Granuloma, Pyogenic* ; Humans ; Recurrence ; Shoulder*

Familial benign chronic pemphigua is a rare disease characterized by a localized recurrent eruption of grouped vesicles and exudative lesions involving the neck, groin, axillae and intertriginous areas. There are no systemic manifestations but chronicity and pruritic lesions creates a significant social and psychological handicap to those afflicted. We presented a case of familial benign chronic pemphigus in a 39 years old man He has had recurrent vesicles, fissures and crust formation in inguinal area for 10 years. Light microscopic findings showed suprabasal vesiculation with acantholysis and villi formation. And electron-microscopic findings showed as follows: Bizzare microvilli changes with widened intercellular spaces, followed by loss of desmosome and complete acantholysis. Tonofilament-desmosome complex is disrupted. Many of acantholytic cells are associated with abnormal keratinization which is repreaented by perinuclear thickened bundles of tonofilament arranged in whorls or lumps. Authors diagnosed with clinical symptoms, light and electron-microscopic findings as Hailey-Hailey disease. The lesions were improved by systemic antibiotics and steroid with cold soaking.
Acantholysis ; Adult ; Anti-Bacterial Agents ; Axilla ; Desmosomes ; Extracellular Space ; Groin ; Humans ; Intermediate Filaments ; Microvilli ; Neck ; Pemphigus, Benign Familial* ; Rare Diseases

No abstract available.
Xanthomatosis*

We observed 2 cases of multiple trichoepithelioma, which occured in 25-year- old male and 20-year-old female. They visited our department for multiple skin rashes on the face of 8 years duration in male and 7 years' duration in female patient. Both of them have similar skin lesions characterized by multiplel waxy gshiny, skin colored, firm papules scattered on the nasolabial folds, both eyelids and forehead. Each one of them has a history of similar skin lesions in the family. Literatures are briefly reviewed for discussion of clinical and histopathologicl findings in this disease.
Exanthema ; Eyelids ; Female ; Forehead ; Humans ; Male ; Nasolabial Fold ; Skin ; Young Adult

A case of crotamiton resistant scabies is described in a 21-year-old male patient The scrapings using mineral oil from lesions on the wrist and finger webs showed mites and eggs, typical of scabies. Ten percent crotamitn cream was applied 10 times in one month without any effect. We could not find any source of reinfection in the patient. After above treatment the scrapings still showed mites. and eggs. Retreatment with 1% gamma benzene hexachloride cream was effective in clearing of the skin rashes and itching sensation.
Eggs ; Exanthema ; Fingers ; Humans ; Lindane ; Male ; Mineral Oil ; Mites ; Ovum ; Pruritus ; Retreatment ; Scabies* ; Sensation ; Wrist ; Young Adult

No abstract available.

OBJECTIVE: To determine the effects of integrative art therapy on social competence and hand function in children with cerebral palsy. METHOD: Nine children with cerebral palsy were given integrative art therapy and conventional occupational therapy for 50 minutes, once a week over 6 months. Ten children were selected as a control group and were given only conventional occupational therapy. To estimate the effectiveness of integrative art therapy, both groups were evaluated by Denver Developmental Screening Test (DDST-II), Box and Block test and Walker-McConnell scale before and after therapy. RESULTS: Children of integrative art therapy showed significant improvement in 'personal and social' category of DDST-II and 'adaptive behavior' and 'adjustment to social relationships with peers' of Walker-McConnell scale. They also showed improvement of Box and Block test. CONCLUSION: This study revealed that integrative art therapy was effective on social competence as well as hand function in children with cerebral palsy. So, integrative art therapy is expected to be an adjuvant therapy for children with cerebral palsy.
Art Therapy* ; Cerebral Palsy* ; Child* ; Hand* ; Humans ; Mass Screening ; Mental Competency* ; Occupational Therapy

Portal vein thrombosis is an uncommon cause for presinusodal portal hypertension. Several predisposing conditions are known to exist in the background of portal vein thrombosis including infection, malignancies, and coagulation disorders. Recently, there has been growing interest and recognition of antiphospholipid syndrome in association with acquired hypercoagulable state. This syndrome consists of thrombosis of veins or arteries, frequent fetal loss, and association of lupus anticoagulant or anti-Cardiolipin antibodies. We report the case of a 29-year-old male diagnosed with portal vein thrombosis associated with antiphospholipid syndrome.
Adult ; Antibodies ; Antiphospholipid Syndrome* ; Arteries ; Humans ; Hypertension, Portal ; Lupus Coagulation Inhibitor ; Male ; Portal Vein* ; Thrombosis ; Veins ; Venous Thrombosis*

BACKGROUND: Venous thromboembolism (VTE) is rare in pediatric patients compared to adults, but it's incidence is gradually increasing. The purpose of this study was to analyze the incidence, risk factors, and prognosis of pediatric patients with VTE in Korea. METHODS: Between January 2000 and July 2017, 249,312 medical records of the patients older than 1 year who were hospitalized in the department of pediatrics of 10 university hospitals in Yeungnam region were retrospectively reviewed. RESULTS: The overall incidence of VTE was 4.9 per 10,000 admissions. Of the total 123 patients, 80 (65.0%) were male and the median age was 10.8 years (range, 1.0–23.5 years). Magnetic resonance imaging was performed most frequently to confirm the diagnosis of VTE (43.1%). Thrombosis occurred in the cerebral vessels (46.3%), lower extremities (23.8%), pulmonary (19.5%), abdomen (9.8%), and upper extremities (4.1%). One hundred and six patients had underlying causes such as cancer (27.6%), infection (26.8%), intravenous catheter insertion (17.9%), and surgery (14.6%). Protein C was evaluated in 39 patients (31.7%), protein S in 40 (32.5%), antithrombin (AT) III in 52 (42.3%), and homocysteine in 21 (17.1%). Among them, one patient with a family history of AT III deficiency had SERPINC gene mutation. Seventy-seven patients (62.6%) started anticoagulation treatment. Most (52.0%) were treated for more than 90 days. CONCLUSION: Healthcare providers must be aware of the potential for VTE development in childhood. In the near future, a nationwide survey should be investigated to determine the incidence rate and the trends in VTE among Korean children.
Abdomen ; Adult ; Catheters ; Child ; Diagnosis ; Epidemiology ; Health Personnel ; Homocysteine ; Hospitals, University ; Humans ; Incidence ; Korea* ; Lower Extremity ; Magnetic Resonance Imaging ; Male ; Medical Records ; Pediatrics ; Prognosis ; Protein C ; Protein S ; Retrospective Studies ; Risk Factors ; Thrombosis ; Upper Extremity ; Venous Thromboembolism*

Inflammatory bowel disease (IBD) is an idiopathic chronic inflammation of the intestines. IBD treatment may require anti-inflammatory agents such as sulfasalazine or 5-aminosalicylate (5-ASA) and immunomodulators to control the symptoms. However, these agents have a variety of common adverse effects such as nausea, vomiting, skin rash, leukopenia, thrombocytopenia, and infections. Moreover, rare side effects such as nephrotic syndrome, pneumonitis, and pericarditis can occur. A 21-year-old male was admitted to the hospital due to acute chest pain, fever, and sweating. The patient had a history of Crohn's disease and had been taking mesalazine for 3 weeks. Chest x-ray, echocardiography, and clinical manifestations revealed that the patient had acute pericarditis. However, we did not recognize the relationship between these findings and 5-ASA at that time. Two years later, the patient took 5-ASA again, and similar symptoms occurred, which led us to confirm that he suffered from pericarditis induced by this drug. We report a case of acute recurrent pericarditis that developed after taking 5-ASA for IBD treatment with a review of the literature.
Anti-Inflammatory Agents ; Chest Pain ; Colitis, Ulcerative ; Crohn Disease ; Echocardiography ; Exanthema ; Fever ; Humans ; Immunologic Factors ; Inflammation ; Inflammatory Bowel Diseases ; Intestines ; Leukopenia ; Male ; Mesalamine ; Nausea ; Nephrotic Syndrome ; Pericarditis ; Pneumonia ; Sulfasalazine ; Sweat ; Sweating ; Thorax ; Thrombocytopenia ; Vomiting ; Young Adult